Zobrazeno 1 - 10
of 27
pro vyhledávání: '"C A Crutchfield"'
MLKL deficiency elevates testosterone production in male mice independently of necroptotic functions
Autor:
Shene Chiou, Wayne Cawthorne, Thomas Soerianto, Vinzenz Hofferek, Komal M. Patel, Sarah E. Garnish, Emma C. Tovey Crutchfield, Cathrine Hall, Joanne M. Hildebrand, Malcolm J. McConville, Kate E. Lawlor, Edwin D. Hawkins, Andre L. Samson, James M. Murphy
Publikováno v:
Cell Death and Disease, Vol 15, Iss 11, Pp 1-10 (2024)
Abstract Mixed lineage kinase domain-like (MLKL) is a pseudokinase, best known for its role as the terminal effector of the necroptotic cell death pathway. MLKL-mediated necroptosis has long been linked to various age-related pathologies including ne
Externí odkaz:
https://doaj.org/article/3e983790f4d740f6875bec76ced943af
Autor:
Sarah E. Garnish, Katherine R. Martin, Maria Kauppi, Victoria E. Jackson, Rebecca Ambrose, Vik Ven Eng, Shene Chiou, Yanxiang Meng, Daniel Frank, Emma C. Tovey Crutchfield, Komal M. Patel, Annette V. Jacobsen, Georgia K. Atkin-Smith, Ladina Di Rago, Marcel Doerflinger, Christopher R. Horne, Cathrine Hall, Samuel N. Young, Matthew Cook, Vicki Athanasopoulos, Carola G. Vinuesa, Kate E. Lawlor, Ian P. Wicks, Gregor Ebert, Ashley P. Ng, Charlotte A. Slade, Jaclyn S. Pearson, André L. Samson, John Silke, James M. Murphy, Joanne M. Hildebrand
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Across the globe, 2-3% of humans carry the p.Ser132Pro single nucleotide polymorphism in MLKL, the terminal effector protein of the inflammatory form of programmed cell death, necroptosis. Here we show that this substitution confers a gain i
Externí odkaz:
https://doaj.org/article/14198b0aa4ad4e93a3c3095f5a9f9cb4
Autor:
Emma C. Tovey Crutchfield, Sarah E. Garnish, Jessica Day, Holly Anderton, Shene Chiou, Anne Hempel, Cathrine Hall, Komal M. Patel, Pradnya Gangatirkar, Katherine R. Martin, Connie S. N. Li Wai Suen, Alexandra L. Garnham, Andrew J. Kueh, Ian P. Wicks, John Silke, Ueli Nachbur, Andre L. Samson, James M. Murphy, Joanne M. Hildebrand
Publikováno v:
Cell Death & Differentiation. 30:1059-1071
MLKL and RIPK3 are the core signaling proteins of the inflammatory cell death pathway, necroptosis, which is a known mediator and modifier of human disease. Necroptosis has been implicated in the progression of disease in almost every physiological s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::beda966f369535a227d56fb3a55154fd
https://doi.org/10.1038/s41418-023-01121-4
https://doi.org/10.1038/s41418-023-01121-4
Publikováno v:
Biomolecules, Vol 11, Iss 6, p 803 (2021)
Necroptosis is an inflammatory form of lytic programmed cell death that is thought to have evolved to defend against pathogens. Genetic deletion of the terminal effector protein—MLKL—shows no overt phenotype in the C57BL/6 mouse strain under conv
Externí odkaz:
https://doaj.org/article/5c40b4aadc5b4564822b5275d0521ff5
Autor:
Sarah E. Garnish, Katherine R. Martin, Maria Kauppi, Victoria Jackson, Rebecca Ambrose, Vik Ven Eng, Shene Chiou, Yanxiang Meng, Daniel Frank, Emma C. Tovey Crutchfield, Komal M. Patel, Annette V. Jacobsen, Georgia K. Atkin-Smith, Ladina Di Rago, Marcel Doerflinger, Christopher R. Horne, Cathrine Hall, Samuel N. Young, Vicki Athanasopoulos, Carola G. Vinuesa, Kate E. Lawlor, Ian P. Wicks, Gregor Ebert, Ashley P. Ng, Charlotte A. Slade, Jaclyn S. Pearson, Andre L. Samson, John Silke, James M. Murphy, Joanne M. Hildebrand
Across the globe, 2-3% of humans carry thep.Ser132Prosingle nucleotide polymorphism inMLKL, the terminal effector protein of the inflammatory form of programmed cell death, necroptosis. We show that this substitution confers a gain in necroptotic fun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76a87e8c3dff272665426cae38e0ed51
https://doi.org/10.1101/2022.09.08.507056
https://doi.org/10.1101/2022.09.08.507056
Publikováno v:
Immunology & Cell Biology. 99:800-802
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b35df29e5d0723f526d7c491e6907b04
https://doi.org/10.1111/imcb.12489
https://doi.org/10.1111/imcb.12489
Publikováno v:
Biomolecules, Vol 11, Iss 803, p 803 (2021)
Biomolecules
Biomolecules
Necroptosis is an inflammatory form of lytic programmed cell death that is thought to have evolved to defend against pathogens. Genetic deletion of the terminal effector protein – MLKL – shows no overt phenotype in the C57BL/6 mouse strain under
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba02fd3382d0da1cfc659cf1b074e8e8
https://doi.org/10.20944/preprints202105.0053.v1
https://doi.org/10.20944/preprints202105.0053.v1
Publikováno v:
Pediatric Dermatology. 17:484-486
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5bc1a6292aa55c5e650a11b28f3e2d2
https://doi.org/10.1046/j.1525-1470.2000.01832.x
https://doi.org/10.1046/j.1525-1470.2000.01832.x
Publikováno v:
Cutis. 64(1)
Two patients developed an irritant dermatitis of the axillae shortly after using an over-the-counter "natural deodorant crystal" product containing alum. We discuss this previously unreported, untoward reaction to alum, an ancient agent with newfound
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f699e88c28a841335a66b48093f04b14
https://pubmed.ncbi.nlm.nih.gov/10431678
https://pubmed.ncbi.nlm.nih.gov/10431678
Publikováno v:
Cutis. 63(4)
Smoking has been shown to be associated with many medical disorders, including many involving the skin. While preliminary studies suggest a modest association between smoking and systemic lupus erythematosus, epidemiologic data on discoid lupus eryth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a205e6b1298f891b005f08d189fd618a
https://pubmed.ncbi.nlm.nih.gov/10228753
https://pubmed.ncbi.nlm.nih.gov/10228753