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Akademický článek

Clinical utility of combinatorial pharmacogenomic testing in depression: A Canadian patient- and rater-blinded, randomized, controlled trial

Publikováno v: Translational Psychiatry, Vol 12, Iss 1, Pp 1-10 (2022)

Abstract The pharmacological treatment of depression consists of stages of trial and error, with less than 40% of patients achieving remission during first medication trial. However, in a large, randomized-controlled trial (RCT) in the U.S. (“GUIDE

Externí odkaz: https://doaj.org/article/40ed16eb2b844f418d55e066132dd8d5

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Akademický článek

Active immunotherapy and alternative therapeutic modalities for Alzheimer's disease

Autor: Stacie Weninger, Bjorn Sperling, Robert Alexander, Magnus Ivarsson, Fiona M. Menzies, Peter Powchik, Christopher J. Weber, C. Anthony Altar, Ronald G. Crystal, Stephen J. Haggarty, Jeanne Loring, Lisa J. Bain, Maria C. Carrillo

Publikováno v: Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 6, Iss 1, Pp n/a-n/a (2020)

Abstract As knowledge of Alzheimer's disease (AD) progression improves, the field has recognized the need to diversify the pipeline, broaden strategies and approaches to therapies, as well as delivery mechanisms. A better understanding of the earlies

Externí odkaz: https://doaj.org/article/aad32129c56e420799a40117763c7ff7

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GWAS quality score for evaluating associated regions in GWAS analyses

Autor: Swapnil Awasthi, Chia-Yen Chen, Max Lam, Hailiang Huang, Stephan Ripke, C Anthony Altar

Publikováno v: Bioinformatics. 39

Motivation The number of significantly associated regions reported in genome-wide association studies (GWAS) for polygenic traits typically increases with sample size. A traditional tool for quality control and identification of significant regions h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1b17af47b1a358919a7774a0413f1d3d
https://doi.org/10.1093/bioinformatics/btad004

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Active immunotherapy and alternative therapeutic modalities for Alzheimer's disease

Autor: Robert Alexander, Lisa J. Bain, Peter Powchik, Maria C. Carrillo, Ronald G. Crystal, Stacie Weninger, Magnus Ivarsson, C. Anthony Altar, Bjorn Sperling, Christopher J. Weber, Fiona M. Menzies, Stephen J. Haggarty, Jeanne F. Loring

Publikováno v: Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 6, Iss 1, Pp n/a-n/a (2020)
Alzheimer's & Dementia : Translational Research & Clinical Interventions

As knowledge of Alzheimer's disease (AD) progression improves, the field has recognized the need to diversify the pipeline, broaden strategies and approaches to therapies, as well as delivery mechanisms. A better understanding of the earliest biologi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21360cee9fe532e6bed181a1648baed7
https://doi.org/10.1002/trc2.12090

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Akademický článek

Cell-Mediated Delivery of Brain-Derived Neurotrophic Factor Enhances Dopamine Levels in an Mpp+ Rat Model of Substantia Nigra Degeneration

Autor: Wendy R. Galpern, David M. Frim, Stephen B. Tatter, C. Anthony Altar, M. Flint Beal, Ole Isacson

Publikováno v: Cell Transplantation, Vol 5 (1996)

Brain-derived neurotrophic factor (BDNF) promotes the survival of fetal mesencephalic dopaminergic cells and protects dopaminergic neurons against the toxicity of MPP+ in vitro. Supranigral implantation of fibroblasts genetically engineered to secret

Externí odkaz: https://doaj.org/article/62b0225114b840b587aade66e16f8464

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Combinatorial pharmacogenomic guidance for psychiatric medications reduces overall pharmacy costs in a 1 year prospective evaluation

Autor: Susan Garavaglia, Andrew G Marshak, Seth Goldfarb, Josiah D. Allen, Joseph M Carhart, Joel G. Winner, Kelly K Parsons, Gabriela Lavezzari, C Anthony Altar, Bryan Dechairo

Publikováno v: Current Medical Research and Opinion. 31:1633-1643

The objective of this project was to determine pharmacy cost savings and improvement in adherence based on a combinatorial pharmacogenomic test (CPGx ) in patients who had switched or added a new psychiatric medication after having failed monotherapy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c24937c500cc7438bee6d343016c97c0
https://doi.org/10.1185/03007995.2015.1063483

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Clinical Utility of Combinatorial Pharmacogenomics-Guided Antidepressant Therapy: Evidence from Three Clinical Studies

Autor: Joel G. Winner, C Anthony Altar, Daniel K. Hall-Flavin, Bryan Dechairo, Josiah D. Allen, Joseph M Carhart

Publikováno v: Complex Psychiatry. 1:145-155

DNA of 258 patients with treatment-resistant depression was collected in three 8-10 week, two-arm, prospective clinical trials. Forty-four allelic variations were measured in genes for the cytochrome P450 (CYP) enzymes CYP2D6, CYPC19, and CYP1A2, the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faec7f0adafe38b994938c17e99bbfa0
https://doi.org/10.1159/000430915

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