Výsledky vyhledávání - "C A, Poquette"

Antitumor activity of temozolomide combined with irinotecan is partly independent of O6-methylguanine-DNA methyltransferase and mismatch repair phenotypes in xenograft models

Autor: P J, Houghton, C F, Stewart, P J, Cheshire, L B, Richmond, M N, Kirstein, C A, Poquette, M, Tan, H S, Friedman, T P, Brent

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 6(10)

The activity of temozolomide combined with irinotecan (CPT-11) was evaluated against eight independent xenografts (four neuroblastomas, three rhabdomyosarcomas, and one glioblastoma). In all studies, temozolomide was administered p.o. daily for 5 con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5f6ffbf0fba12111a064c367aad4c994
https://pubmed.ncbi.nlm.nih.gov/11051264

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P53 mutation and MDM2 amplification frequency in pediatric rhabdomyosarcoma tumors and cell lines

Autor: A C, Taylor, L, Shu, M K, Danks, C A, Poquette, S, Shetty, M J, Thayer, P J, Houghton, L C, Harris

Publikováno v: Medical and pediatric oncology. 35(2)

The p53 tumor suppressor gene is the most commonly mutated gene in human cancer, and mutations arise in a wide variety of tumor types. Wild-type p53 functions as a regulator of apoptosis, so mutations in the p53 gene are generally associated with agg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7dca2a7d3ef81c944bba309b5072644d
https://pubmed.ncbi.nlm.nih.gov/10918230

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Bone sarcomas of the head and neck in children: the St Jude Children's Research Hospital experience

Autor: N C, Daw, H H, Mahmoud, W H, Meyer, J J, Jenkins, S C, Kaste, C A, Poquette, L E, Kun, C B, Pratt, B N, Rao

Publikováno v: Cancer. 88(9)

Bone sarcomas of the head and neck are difficult to resect. The authors reviewed their institutional experience with these tumors to characterize patients' clinical findings and to assess the impact of surgical resection on outcome.The records of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e3f438a9279ef7964e1ddc992db959f5
https://pubmed.ncbi.nlm.nih.gov/10813731

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Synergy of topotecan in combination with vincristine for treatment of pediatric solid tumor xenografts

Autor: J, Thompson, E O, George, C A, Poquette, P J, Cheshire, L B, Richmond, S S, de Graaf, M, Ma, C F, Stewart, P J, Houghton

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 5(11)

Topotecan and vincristine were evaluated alone or in combination against 13 independent xenografts and 1 vincristine-resistant derivative, representing childhood neuroblastoma (n = 6), rhabdomyosarcoma (n = 5), or brain tumors (n = 3). Topotecan was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::eecd1cb2e27ac9258cb329986486706c
https://pubmed.ncbi.nlm.nih.gov/10589779

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Bax is an important determinant of chemosensitivity in pediatric tumor cell lines independent of Bcl-2 expression and p53 status

Autor: C R, McPake, D M, Tillman, C A, Poquette, E O, George, J A, Houghton, L C, Harris

Publikováno v: Oncology research. 10(5)

Susceptibility of a tumor cell to undergo chemotherapy-induced apoptosis appears to be dependent upon the balance of proapoptotic and survival factors that are expressed within any given cell. We have chosen to evaluate how expression of several of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::83b009ba70815d2528c05bf8a04b051f
https://pubmed.ncbi.nlm.nih.gov/9802058

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