Zobrazeno 1 - 10
of 13
pro vyhledávání: '"C A, Omer"'
Autor:
C A Omer, Patrick J. Casey, Bruno Giros, Fang L. Zhang, Jackson B. Gibbs, Nancy E. Kohl, R E Diehl
Publikováno v:
Journal of Biological Chemistry. 269:3175-3180
Protein geranylgeranyltransferase type-I (GGTase-I) transfers a geranylgeranyl group to the cysteine residue of candidate proteins containing a carboxyl-terminal CAAX (C, cysteine; A, aliphatic amino acid; X, any amino acid) motif in which the "X" re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1322d5b63b646e0a7f15debdfa79fee9
https://doi.org/10.1016/s0021-9258(17)41845-x
https://doi.org/10.1016/s0021-9258(17)41845-x
Autor:
C. A. Omer, J. B. Gibbs
Publikováno v:
Molecular Microbiology. 11:219-225
Summary Modrfication of proteins at C-terminal cysteine residue(s) by the isoprenoids farnesyl (C15) and geranylgeranyl (C20) is essential for the biological function of a number of eukaryotic proteins including fungal mating factors and the small, G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c44f1051051fd867ca33066d0e3f3a49
https://doi.org/10.1111/j.1365-2958.1994.tb00302.x
https://doi.org/10.1111/j.1365-2958.1994.tb00302.x
Autor:
C A, Omer, Z, Chen, R E, Diehl, M W, Conner, H Y, Chen, M E, Trumbauer, S, Gopal-Truter, G, Seeburger, H, Bhimnathwala, M T, Abrams, J P, Davide, M S, Ellis, J B, Gibbs, I, Greenberg, K S, Koblan, A M, Kral, D, Liu, R B, Lobell, P J, Miller, S D, Mosser, T J, O'Neill, E, Rands, M D, Schaber, E T, Senderak, A, Oliff, N E, Kohl
Publikováno v:
Cancer research. 60(10)
For Ras oncoproteins to transform mammalian cells, they must be posttranslationally modified with a farnesyl group in a reaction catalyzed by the enzyme farnesyl:protein transferase (FPTase). Inhibitors of FPTase have therefore been developed as pote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2912ec44ca2d1ecb77982ce053c4c10a
https://pubmed.ncbi.nlm.nih.gov/10825141
https://pubmed.ncbi.nlm.nih.gov/10825141
Publikováno v:
Methods in enzymology. 250
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e34c857da59c9822fbd9aabdcc8cfc12
https://pubmed.ncbi.nlm.nih.gov/7544423
https://pubmed.ncbi.nlm.nih.gov/7544423
Publikováno v:
The Journal of biological chemistry. 269(5)
Protein geranylgeranyltransferase type-I (GGTase-I) transfers a geranylgeranyl group to the cysteine residue of candidate proteins containing a carboxyl-terminal CAAX (C, cysteine; A, aliphatic amino acid; X, any amino acid) motif in which the "X" re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::925b6fff9f08cd8159f69e401d377066
https://pubmed.ncbi.nlm.nih.gov/8106351
https://pubmed.ncbi.nlm.nih.gov/8106351
Publikováno v:
Cell growthdifferentiation : the molecular biology journal of the American Association for Cancer Research. 4(9)
The Ras oncoprotein must be modified by farnesyl transferase (FTase) for biological activity. Therefore, inhibition of FTase may offer a means to block ras induced cell transformation. To address this hypothesis, we have introduced antisense and domi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::923131d79ccf231e3caa10a9edeb2bd1
https://pubmed.ncbi.nlm.nih.gov/8241019
https://pubmed.ncbi.nlm.nih.gov/8241019
Publikováno v:
Journal of Virology. 50:465-470
Employing enzymatic reactions in vitro, we have identified the presence of oligoribonucleotides at the 5' end of strong-stop plus [(+)] DNA. Similar results were obtained whether the strong-stop (+) DNA was synthesized by preparations of detergent-di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::127787f7c6a40fc75664404976b7c845
https://doi.org/10.1128/jvi.50.2.465-470.1984
https://doi.org/10.1128/jvi.50.2.465-470.1984
Publikováno v:
Journal of bacteriology. 170(5)
We report that transformation of Streptomyces lividans with cloned DNA of the SLP1 genetic element results in integration of the element at the same chromosomal locus (attB) normally occupied by SLP1 in its original host, Streptomyces coelicolor, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::313768a47235cfc27a9bbc5a210d3cd0
https://pubmed.ncbi.nlm.nih.gov/2834330
https://pubmed.ncbi.nlm.nih.gov/2834330
Publikováno v:
Europe PubMed Central
Avian tumor virus supercoiled DNA was isolated from infected quail tumor cells and molecularly cloned in pBR322. Four different recombinant clones denoted pATV-6, pATV-7, pATV-8, and pATV-9 were characterized in detail by restriction endonuclease map
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dc022efa20aff9381903f699e5638ab
https://pubmed.ncbi.nlm.nih.gov/6283156
https://pubmed.ncbi.nlm.nih.gov/6283156
Autor:
C A Omer, Stanley N. Cohen
Publikováno v:
Journal of bacteriology. 166(3)
SLP1int (integrated [int] form of Streptomyces lividans plasmid 1 [SLP1]) is a Streptomyces coelicolor A3(2) transmissible sequence capable of autonomous replication as well as site-specific integration into and excision from the S. coelicolor chromo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37960a4e512eb718e57d670027a27643
https://pubmed.ncbi.nlm.nih.gov/3011759
https://pubmed.ncbi.nlm.nih.gov/3011759