Zobrazeno 1 - 10
of 35
pro vyhledávání: '"C A, O'Brian"'
Autor:
T. Smith, C. A. O'Brian, Merrick I. Ross, Carl Plager, Nicholas E. Papadopoulos, Julie A. Ellerhorst, Agop Y. Bedikian, Omar Eton, J. R. Stewart, S. K. Herdman
Publikováno v:
Melanoma Research. 11:183-188
In this phase II study we assessed the efficacy of bryostatin-1 (NSC 339555) in metastatic melanoma patients when given intravenously either once a week at a dose of 25 microg/m2 per day over 24 h for 3 weeks or at 40 microg/m2 per day over 72 h ever
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::151bf0c62361be77fa21b302be4aa213
https://doi.org/10.1097/00008390-200104000-00014
https://doi.org/10.1097/00008390-200104000-00014
Publikováno v:
Scandinavian Journal of Immunology. 39:39-44
In this study the effect of various Protein kinase C (PKC) activators/tumour promoters on the maturation and activity of human peripheral blood monocytes was examined. Monocytes were cultured in the absence or presence of various PKC activators for u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8826cff1de62f66c4db9bdf04a728eb6
https://doi.org/10.1111/j.1365-3083.1994.tb03337.x
https://doi.org/10.1111/j.1365-3083.1994.tb03337.x
Publikováno v:
The Journal of Immunology. 145:2566-2570
Retroviral infection is associated with immunosuppression, which has been shown to be due, in part, to the action of the envelope protein p15E. We studied a synthetic peptide (CKS-17) homologous to a highly conserved domain of the retroviral envelope
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c05d7582cdf338c016b515b78c940fa0
https://doi.org/10.4049/jimmunol.145.8.2566
https://doi.org/10.4049/jimmunol.145.8.2566
Publikováno v:
Cancer metastasis reviews. 20(1-2)
The seminal discovery in 1988 that selective protein kinase C (PKC) activators induce multidrug resistance (MDR) in human cancer cells spawned several years of intensive investigations; these studies were primarily directed at the question of whether
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e46169fbe7ac9c5c010aac62f2da1136
https://pubmed.ncbi.nlm.nih.gov/11831653
https://pubmed.ncbi.nlm.nih.gov/11831653
Autor:
A, Castilleja, N E, Ward, C A, O'Brian, B, Swearingen, E, Swan, M A, Gillogly, J L, Murray, A P, Kudelka, D M, Gershenson, C G, Ioannides
Publikováno v:
Molecular and cellular biochemistry. 217(1-2)
We investigated the ubiquitination and degradation of a tumor antigen, the HER-2/neu (HER-2) protooncogene product which is overexpressed in epithelial cancers. HER-2 degradation was investigated in the ovarian tumor line, SKOV3.A2, that constitutive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d902ce9196a01110dd40a85d5be50886
https://pubmed.ncbi.nlm.nih.gov/11269662
https://pubmed.ncbi.nlm.nih.gov/11269662
Publikováno v:
Biochemical pharmacology. 60(9)
The natural product resveratrol is a potent antagonist of phorbol ester-mediated tumor promotion and in vitro cellular responses to phorbol-ester tumor promoters, but it is only weakly inhibitory against the phosphorylation of conventional exogenous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::14675d8eae5074245568a656c402cc91
https://pubmed.ncbi.nlm.nih.gov/11008129
https://pubmed.ncbi.nlm.nih.gov/11008129
Autor:
B, Fisk, B W, Anderson, K R, Gravitt, C A, O'Brian, A P, Kudelka, J L, Murray, J T, Wharton, C G, Ioannides
Publikováno v:
Cancer research. 57(1)
Identification of naturally processed peptides recognized by tumorspecific CTLs may lead to epitope-specific tumor vaccines. Because these epitopes may be expressed differently on epithelial tumors and may differ in their ability to induce CTL in viv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::db1d06737d72a4282b8a30abba0037ad
https://pubmed.ncbi.nlm.nih.gov/8988046
https://pubmed.ncbi.nlm.nih.gov/8988046
Publikováno v:
The Journal of biological chemistry. 271(39)
We recently reported that the peptide substrate analog Arg-Lys-Arg-Cys-Leu-Arg-Arg-Leu (RKRCLRRL) irreversibly inactivates the protein kinase C (PKC) isozymes alpha, beta, and gamma in a dithiothreitol-sensitive manner by an active site-directed mech
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d6ec2fd89476c002574306cb708e959c
https://pubmed.ncbi.nlm.nih.gov/8798661
https://pubmed.ncbi.nlm.nih.gov/8798661
Publikováno v:
Progress in clinical and biological research. 391
The high affinity receptor of phorbol-ester and related tumor promoters is the isozyme family protein kinase C (PKC). Activation of PKC by the phorbol esters is a pivotal event in phorbol ester-mediated tumor promotion. PKC activation is also implica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f53f7bb923b715e3dd7e9811b2b82381
https://pubmed.ncbi.nlm.nih.gov/8532710
https://pubmed.ncbi.nlm.nih.gov/8532710
Publikováno v:
Oncology research. 7(9)
We evaluated the therapeutic efficacy against murine drug-sensitive and drug-resistant tumor of a combination chemotherapy regimen comprising intravenous administration of doxorubicin (DXR) plus oral administration of the staurosporine analogue CGP 4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::59fe097c322749f5180d1a59ec4b2602
https://pubmed.ncbi.nlm.nih.gov/8835289
https://pubmed.ncbi.nlm.nih.gov/8835289