Zobrazeno 1 - 9 of 9 pro vyhledávání: '"C A, McWherter"'
1
A203 ACTIVITY OF MBX-8025, A POTENT AND SELECTIVE PPAR-δ AGONIST, ON BIOCHEMICAL MARKERS OF CHOLESTASIS
Autor: C A McWherter, Y Choi, P F Boudes, Alexandra Steinberg
Publikováno v: Journal of the Canadian Association of Gastroenterology. 1:355-356
BACKGROUND: MBX-8025 is a potent and selective PPAR-delta agonist that decreases LDL-Cholesterol in subjects with mixed dyslipidemia and subjects with homozygous familial hypercholesterolemia (HoFH). AIMS: Herein, we describe the activity of MBX-8025
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4416d53fcf2b9a922884ddd9d36bdfe
https://doi.org/10.1093/jcag/gwy008.204
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2
A comparative analysis of the kinetic mechanism and peptide substrate specificity of human and Saccharomyces cerevisiae myristoyl-CoA:protein N-myristoyltransferase
Autor: C A McWherter, D C Wood, W J Rocque, J I Gordon
Publikováno v: Journal of Biological Chemistry. 268:9964-9971
Human myristoyl-CoA:protein N-myristoyltransferase (hNmt) catalyzes the transfer of myristate from CoA to the amino-terminal Gly residue of a number of cellular proteins involved in signal transduction pathways, to structural and nonstructural protei
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::253bafe57c8e4fb9e35a6fd5b1454366
https://doi.org/10.1016/s0021-9258(18)82159-7
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3
Selective peptidic and peptidomimetic inhibitors of Candida albicans myristoylCoA: protein N-myristoyltransferase: a new approach to antifungal therapy
Autor: J A, Sikorski, B, Devadas, M E, Zupec, S K, Freeman, D L, Brown, H F, Lu, S, Nagarajan, P P, Mehta, A C, Wade, N S, Kishore, M L, Bryant, D P, Getman, C A, McWherter, J I, Gordon
Publikováno v: Biopolymers. 43(1)
MyristoylCoA: protein N-myristoyltransferase (NMT) catalyzes the cotranslational covalent attachment of a rare cellular fatty acid, myristate, to the N-terminal Gly residue of a variety of eukaryotic proteins. The myristoyl moiety is often essential
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3f31eb6fcf10f1caf89515f800ac81ca
https://pubmed.ncbi.nlm.nih.gov/9174411
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4
A comparative analysis of the kinetic mechanism and peptide substrate specificity of human and Saccharomyces cerevisiae myristoyl-CoA:protein N-myristoyltransferase
Autor: W J, Rocque, C A, McWherter, D C, Wood, J I, Gordon
Publikováno v: The Journal of biological chemistry. 268(14)
Human myristoyl-CoA:protein N-myristoyltransferase (hNmt) catalyzes the transfer of myristate from CoA to the amino-terminal Gly residue of a number of cellular proteins involved in signal transduction pathways, to structural and nonstructural protei
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::69efa67b37650ae657039f1bedcf734a
https://pubmed.ncbi.nlm.nih.gov/8486723
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6
Kinetic and structural evidence for a sequential ordered Bi Bi mechanism of catalysis by Saccharomyces cerevisiae myristoyl-CoA:protein N-myristoyltransferase
Autor: D A, Rudnick, C A, McWherter, W J, Rocque, P J, Lennon, D P, Getman, J I, Gordon
Publikováno v: The Journal of biological chemistry. 266(15)
The mechanism of catalysis of Escherichia coli-derived Saccharomyces cerevisiae myristoyl-CoA: protein N-myristoyltransferase (NMT) has been characterized. Previous studies indicated that a high affinity reaction intermediate forms between NMT and my
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::38b444a6eb545490ece87fd4e2ec9a01
https://pubmed.ncbi.nlm.nih.gov/2033063
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7
Structural and functional studies of Saccharomyces cerevisiae myristoyl-CoA:protein N-myristoyltransferase produced in Escherichia coli. Evidence for an acyl-enzyme intermediate
Autor: D A, Rudnick, C A, McWherter, S P, Adams, I J, Ropson, R J, Duronio, J I, Gordon
Publikováno v: The Journal of biological chemistry. 265(22)
Saccharomyces cerevisiae myristoyl-CoA:protein N-myristoyltransferase has been efficiently expressed in Escherichia coli and subsequently purified to homogeneity using phosphocellulose chromatography. The interactions between apoenzyme and its acyl-C
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7aee87b9a05468f0fbf4a064f8eeb35f
https://pubmed.ncbi.nlm.nih.gov/2198291
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8
Conformational unfolding in the N-terminal region of ribonuclease a detected by nonradiative energy transfer: Distribution of interresidue distances in the native, denatured, and reduced-denatured states
Autor: C. A. McWherter, Elisha Haas, Harold A. Scheraga
Publikováno v: Biopolymers. 27:1-21
Time-dependent fluorescence measurements have been used to determine the distribution of distances between probes attached to residues 1 and (49 + 53) of bovine pancreatic ribonuclease A in the native, denatured, and reduced-denatured states. Measure
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c6051df67a986893e85ec4cc9e112c9
https://doi.org/10.1002/bip.360270102
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9
Peptide mapping of bovine pancreatic ribonuclease A by reverse-phase high-performance liquid chromatography. II. A two-dimensional technique for determination of disulfide pairings using a continuous-flow disulfide-detection system
Autor: T W, Thannhauser, C A, McWherter, H A, Scheraga
Publikováno v: Analytical biochemistry. 149(2)
A procedure, developed for the cleavage and reversible blocking of disulfide bonds of proteins by S-sulfonation in preparation for peptide mapping, was applied to ribonuclease A. The complete peptide maps of sulforibonuclease A using limited Staphylo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2c3cd1b32214a9b4045d448df5ab4b7c
https://pubmed.ncbi.nlm.nih.gov/3907407
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