Zobrazeno 1 - 10
of 74
pro vyhledávání: '"C A, McFarlane"'
Autor:
C L McFarlane, Peter W New
Publikováno v:
Spinal Cord. 51:453-456
Retrospective open cohort.To calculate the survival of patients with spinal cord infarction and to compare the cause of death in patients with different mechanisms of ischaemic injury.Spinal Rehabilitation Unit, Melbourne, Victoria, Australia.Consecu
Publikováno v:
Genetics and Molecular Research. 10:3246-3250
The Pacific lamprey (Entosphenus tridentatus) is an anadromous fish that is of conservation concern in North America and Asia. Data on Pacific lamprey population structure are scarce and conflicting, impeding conservation efforts. We optimized 12 pol
Publikováno v:
Bulletin des Sociétés Chimiques Belges. 85:864-871
Rhodium-103 chemical shifts have been measured by 1H-{103Rh} heteronuclear double resonance in a series of octahedral rhodium (III) complexes with phosphine/chalcogen ligands, including some mixed species. The shifts are significantly temperature dep
Publikováno v:
Colloid & Polymer Science. 278:450-458
Disruption of polystyrene latex aggregates, formed in 1 M citric acid/phosphate buffer solution at pH 3.8 through diffusion-limited colloid aggregation (DLCA) and in 0.2 M NaCl solution at pH 5.5 through reaction-limited colloid aggregation (RLCA), w
Publikováno v:
Colloid & Polymer Science. 277:325-333
The fractal nature of latex particles and their aggregates was characterised by image analysis in terms of fractal dimensions. The one- and two-dimensional fractal dimensions, D1 and D2, were estimated for polystyrene latex aggregates formed by flocc
Autor:
C. S. Mcfarlane, Robert Zamboni, C. Rochette, M. McAuliffe, Claude Dufresne, P. Prasit, Jacques-Yves Gauthier, Nicole Sawyer, P. Roy, Kathleen M. Metters, Thomas R. Jones, Daniel Guay
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 8:453-458
The structure-activity relationship of a series of styrylpyridine analogs of MK-0476 (montelukast, Singulair) is described. This work has led to the identification of a number of potent and orally active cysLT1 receptor (LTD4 receptor) antagonists in
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 76:210-217
The activity of CDP-840, a novel, selective phosphodiesterase IV inhibitor was determined in a leukotriene-dependent non-human primate model of allergic asthma. Measurements of specific airway resistance (sRaw) were recorded in a dual chamber plethys
Autor:
Deborah A. Nicoll-Griffith, Pierre Hamel, Carole Lepine, C. C. Chan, Chun Li, C. S. Mcfarlane, Yves Girard, James A. Yergey, Yves Ducharme, Daniel Dube, Christine Brideau, Nathalie Chauret, Daniel Delorme, Thomas R. Jones, Rejean Fortin, Denis Riendeau, M. McAuliffe, Jocelyne Guay, Sylvie Desmarais, Jean-Pierre Falgueyret
Publikováno v:
Journal of Medicinal Chemistry. 39:3951-3970
Naphthalenic lignan lactone 3a (L-702,539), a potent and selective 5-lipoxygenase (5-LO) inhibitor, is extensively metabolized at two different sites: the tetrahydropyran and the lactone rings. Early knowledge of the metabolic pathways triggered and
Autor:
M. Belley, Yves Leblanc, Kathleen M. Metters, M. McAuliffe, Nicole Sawyer, Claude Dufresne, Anthony W. Ford-Hutchinson, Robert Zamboni, Deborah Slipetz, Thomas R. Jones, Cheuk K. Lau, Robert N. Young, C.B. Pickett, C. Rochette, C. S. Mcfarlane, Zhaoyin Wang, Helene Perrier, Nathalie Ouimet, Marc Labelle, Yves Gareau, Xiang Yi Bin
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:2551-2556
Structure-activity studies leading to the discovery of a new series of non-quinoline cysLT 1 receptor (LTD 4 receptor) antagonists are described. These studies demonstrated that the quinoline ring system of montelukast ( 5 ) may be replaced by an app
Autor:
Ian G. Campbell, William D. Foulkes, Saliha Afzal, C. P. Mcfarlane, John Trowsdale, Gordon Stamp, N. Lalani
Publikováno v:
British Journal of Cancer
Somatic mutations in TP53 are seen in many human cancers. In addition, the protein product of the wild-type TP53 can be sequestered by the protein MDM2 (murine double minute 2). This protein is commonly overexpressed in human sarcomas and gliomas, us