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Recent Advances in Selective CB2 Agonists for the Treatment of Pain

Autor: E. J. Gilbert, C. A. Lunn

Publikováno v: Anti-Inflammatory Drug Discovery ISBN: 9781849734134

The cannabinoid CB2 receptor is one of a family of GPCRs that mediate the effects of endocannabinoids. Several agonists of this receptor are currently in clinical trials for the treatment of pain and inflammation, indications that have been validated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::38bc5fcfa13324b5e4df1f1090c23750
https://doi.org/10.1039/9781849735346-00391

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Mental Arithmetic: A Componential Analysis of Speed-of-Processing Across Monolingual, Weak Bilingual, and Strong Bilingual Adults

Autor: Patricia Estrada, David C. Geary, Pierre Cormier, Melanie C. E. Lunn, Judith P. Goggin

Publikováno v: International Journal of Psychology. 28:185-201

Two experiments compared rates of solving simple and complex addition and multiplication problems in groups of speakers of French or English in Experiment 1 (n = 35) and Spanish or English in Experiment 2 (n = 84). Subjects were divided into groups o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::94927503103c284ebb2e39052cb12cff
https://doi.org/10.1080/00207599308247184

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Sch35966 is a potent, selective agonist at the peripheral cannabinoid receptor (CB2) in rodents and primates

Autor: W, Gonsiorek, C A, Lunn, X, Fan, G, Deno, J, Kozlowski, R W, Hipkin

Publikováno v: British journal of pharmacology. 151(8)

The peripheral cannabinoid receptor (CB(2)) is expressed on peripheral immune cells and is thought to have a role in the immunosuppressive effects of cannabinoids. Historically, there have been few potent, CB(2)-selective agonists to assess the contr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d90f5436c8b19fab561adba8c7a95c78
https://pubmed.ncbi.nlm.nih.gov/17603556

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Structural characterization of nitric oxide synthase isoforms reveals striking active-site conservation

Autor: T O, Fischmann, A, Hruza, X D, Niu, J D, Fossetta, C A, Lunn, E, Dolphin, A J, Prongay, P, Reichert, D J, Lundell, S K, Narula, P C, Weber

Publikováno v: Nature structural biology. 6(3)

Crystal structures of human endothelial nitric oxide synthase (eNOS) and human inducible NOS (iNOS) catalytic domains were solved in complex with the arginine substrate and an inhibitor S-ethylisothiourea (SEITU), respectively. The small molecules bi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::43af6c3dd9aa3e1d0a0c703762b8ca58
https://pubmed.ncbi.nlm.nih.gov/10074942

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An active covalently linked dimer of human interferon-gamma. Subunit orientation in the native protein

Autor: C A, Lunn, L, Davies, D, Dalgarno, S K, Narula, P J, Zavodny, D, Lundell

Publikováno v: The Journal of biological chemistry. 267(25)

We have constructed and expressed a covalently linked head to tail dimer of human interferon-gamma (IFN-gamma) in which two monomers are joined head to tail via a rigid peptide hinge using genetic engineering techniques. The hinge was derived from th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::92b8597d472fa7c7b36bcacab78dbd41
https://pubmed.ncbi.nlm.nih.gov/1387644

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Isolation and characterization of a protease-nicked thioredoxin

Autor: V Pigiet, C Lantz, M McEvoy, C A Lunn

Publikováno v: Journal of Biological Chemistry. 256:6646-6650

An altered form of thioredoxin, composed of two peptides with molecular weights of 7 and 5 X 10(3) has been isolated from Escherichia coli B after chromatography on Ultrogel AcA54. The position of the clip site, determined by amino acid sequencing to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ac96213898c04ff2d136c0e0aac4f160
https://doi.org/10.1016/s0021-9258(19)69039-3

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Amplification and purification of plasmid-encoded thioredoxin from Escherichia coli K12

Autor: Sidney R. Kushner, S Kathju, V Pigiet, C A Lunn, B J Wallace

Publikováno v: Journal of Biological Chemistry. 259:10469-10474

The thioredoxin gene (trxA) from Escherichia coli K12 has been cloned on a 3-kilobase pair PvuII fragment in a derivative of pBR325 (pBHK8). Thioredoxin protein production was amplified 150-200-fold in a strain containing pBHK8 (SK3981), with the gre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d9b5e022b073119c0655851ba007ef98
https://doi.org/10.1016/s0021-9258(18)90987-7

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Effects of prolipoprotein signal peptide mutations on secretion of hybrid prolipo-beta-lactamase in Escherichia coli

Autor: Masayori Inouye, C A Lunn

Publikováno v: Journal of Biological Chemistry. 262:8318-8324

Hybrid proteins were constructed by coupling beta-lactamase to the signal sequence (plus nine amino acids) of selected mutant prolipoproteins of Escherichia coli. The mutant prolipoprotein signal peptides contained lesions in two structural domains o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f7488d6168e5325ec5972fb833672b94
https://doi.org/10.1016/s0021-9258(18)47566-7

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Defective Escherichia coli signal peptides function in yeast

Autor: Masayori Inouye, O. Pines, C. A. Lunn

Publikováno v: Molecular Microbiology. 2:209-217

Summary To investigate structural characteristics important for eukaryotic signal peptide function In vivo, a hybrid gene with interchangeable signal peptides was cloned into yeast. The hybrid gene encoded nine residues from the amino terminus of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2faba677cadee9d3c94c361610600a5d
https://doi.org/10.1111/j.1365-2958.1988.tb00022.x

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