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Integration of proteomics with CT-based qualitative and radiomic features in high-grade serous ovarian cancer patients: an exploratory analysis

Autor: G. Larry Maxwell, Thomas P. Conrads, John Freymann, Kathleen M. Darcy, Lucian Beer, Evis Sala, Ivana Blazic, Hebert Alberto Vargas, Erich Huang, Hilal Sahin, James D. Brenton, C. Carl Jaffe, Maura Miccò, Justin Kirby, Harini Veeraraghavan, Nicholas W. Bateman, Stephanie Nougaret, Brenda Fevrier-Sullivan

Publikováno v: European Radiology

Objectives To investigate the association between CT imaging traits and texture metrics with proteomic data in patients with high-grade serous ovarian cancer (HGSOC). Methods This retrospective, hypothesis-generating study included 20 patients with H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3395780b4971fde84af241b499e527f

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Radiogenomics of High-Grade Serous Ovarian Cancer: Multireader Multi-Institutional Study from the Cancer Genome Atlas Ovarian Cancer Imaging Research Group

Autor: C. Carl Jaffe, Maria Anello, Vincent M. Mellnick, John Freymann, Yulia Lakhman, Justin Kirby, Brenda Fevrier-Sullivan, Atul B. Shinagare, Priya Bhosale, Erich P. Huang, Hebert Alberto Vargas, Joseph E. Ippolito, Evis Sala

Publikováno v: Radiology. 285:482-492

Purpose To evaluate interradiologist agreement on assessments of computed tomography (CT) imaging features of high-grade serous ovarian cancer (HGSOC), to assess their associations with time-to-disease progression (TTP) and HGSOC transcriptomic profi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5a3afefcee96e386de979fb1164f49b
https://doi.org/10.1148/radiol.2017161870

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A combinatorial radiographic phenotype may stratify patient survival and be associated with invasion and proliferation characteristics in glioblastoma

Autor: Arvind Rao, Ganesh Rao, David A. Gutman, Adam E. Flanders, Scott N. Hwang, Daniel L. Rubin, Rivka R. Colen, Pascal O. Zinn, Rajan Jain, Max Wintermark, Justin S. Kirby, C. Carl Jaffe, John Freymann

Publikováno v: Journal of Neurosurgery. 124:1008-1017

OBJECT Individual MRI characteristics (e.g., volume) are routinely used to identify survival-associated phenotypes for glioblastoma (GBM). This study investigated whether combinations of MRI features can also stratify survival. Furthermore, the molec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::798e378379a8f365c90e8a99f054510c
https://doi.org/10.3171/2015.4.jns142732

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A Three-Dimensional-Printed Patient-Specific Phantom for External Beam Radiation Therapy of Prostate Cancer

Autor: Uma G. Desai, Max C. Dietrich, Christopher L. Lee, C. Carl Jaffe, B. Nicolas Bloch, Suhong Yu, Ariel E. Hirsch, H.F. Xiang, Ankur Das

Publikováno v: Journal of Engineering and Science in Medical Diagnostics and Therapy. 1

This paper presents the design evolution, fabrication, and testing of a novel patient and organ-specific, three-dimensional (3D)-printed phantom for external beam radiation therapy (EBRT) of prostate cancer. In contrast to those found in current prac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e36882a79553ab1acc3fc1cdda838f28
https://doi.org/10.1115/1.4040817

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Hypothyroidism and Wound Healing after Salvage Laryngectomy

Autor: Steven B. Chinn, Andrew G. Shuman, Chaz L. Stucken, Mark E. Prince, Gregory T. Wolf, Ashley L. Miller, Emily Bellile, Matthew E. Spector, Andrew C. Birkeland, C. Carl Jaffe, Carol R. Bradford, Jeffery Moyer, Keith A. Casper, Douglas B. Chepeha, Kevin J. Kovatch, Andrew J. Rosko, Kelly M. Malloy

Publikováno v: Annals of surgical oncology, vol 25, iss 5

BACKGROUND:Patients undergoing salvage laryngectomy are predisposed to radiation-induced hypothyroidism and impaired wound healing secondary to the tissue effects of prior treatment. The impact of hypothyroidism on postoperative wound healing is not

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d5088ffc21bf9808b5524ed7016b698
https://europepmc.org/articles/PMC6002868/

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Outcome Prediction in Patients with Glioblastoma by Using Imaging, Clinical, and Genomic Biomarkers: Focus on the Nonenhancing Component of the Tumor

Autor: John Freymann, C. Carl Jaffe, David A. Gutman, Rivka R. Colen, Tom Mikkelsen, Laila M. Poisson, Justin Kirby, Lisa Scarpace, Rajan Jain, Max Wintermark, Scott N. Hwang, Arvind Rao, Adam E. Flanders, Chad A. Holder

Publikováno v: Radiology. 272:484-493

To correlate patient survival with morphologic imaging features and hemodynamic parameters obtained from the nonenhancing region (NER) of glioblastoma (GBM), along with clinical and genomic markers.An institutional review board waiver was obtained fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::404b5b9f1c20b12e52523c7bd6475025
https://doi.org/10.1148/radiol.14131691

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Implications of New Colorectal Cancer Screening Technologies for Primary Care Practice

Autor: Martin L. Brown, Ann G. Zauber, David F. Ransohoff, Theodore R. Levin, C. Carl Jaffe, Barbara A. Galen

Publikováno v: Medical Care. 46:S138-S146

Colorectal cancer (CRC) screening reduces the risk of CRC mortality but is currently not well utilized, with adherence only 50% in the eligible U.S. population and rates that lag behind those for breast and cervical cancer. The primary care physician

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0988314be368ab12e7ffa6130c7392d7
https://doi.org/10.1097/mlr.0b013e31818192ef

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Blinded Independent Central Review of Progression-Free Survival in Phase III Clinical Trials: Important Design Element or Unnecessary Expense?

Autor: Boris Freidlin, Lori E. Dodd, C. Carl Jaffe, Edward L. Korn, Margaret M. Mooney, Janet Dancey, Larry Rubinstein

Publikováno v: Journal of Clinical Oncology. 26:3791-3796

Progression-free survival is an important end point in advanced disease settings. Blinded independent central review (BICR) of progression in randomized clinical trials has been advocated to control bias that might result from errors in progression a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e447156d463e1c724177b60013702ea
https://doi.org/10.1200/jco.2008.16.1711

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