Výsledky vyhledávání - "C A, JANEWAY"

The orientation of a T cell receptor to its MHC class II:peptide ligands

Autor: S C Hong, D B Sant'Angelo, B N Dittel, R Medzhitov, S T Yoon, P G Waterbury, C A Janeway

Publikováno v: The Journal of Immunology. 159:4395-4402

The TCR found on CD4 T cells recognizes peptides bound to self MHC class II molecules as well as non-self MHC class II molecules. We have used the receptor on a cloned T cell line called D10.G4.1 (D10) to perform a structure-function analysis of this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aea93749072a10040dd79668bd57cdde
https://doi.org/10.4049/jimmunol.159.9.4395

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Peptide antagonists inhibit proliferation and the production of IL-4 and/or IFN-gamma in T helper 1, T helper 2, and T helper 0 clones bearing the same TCR

Autor: B N Dittel, D B Sant'Angelo, C A Janeway

Publikováno v: The Journal of Immunology. 158:4065-4073

Engagement of a TCR by its peptide Ag bound by MHC class II molecules leads to T cell activation, resulting in proliferation and cytokine production. This agonist response can be antagonized by analogue peptides containing single amino acid substitut

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::95e98adb940703d2c612458295f425ba
https://doi.org/10.4049/jimmunol.158.9.4065

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Expression of the co-stimulator molecule B7-1 in pancreatic beta-cells accelerates diabetes in the NOD mouse

Autor: S. Wong, S. Guerder, I. Visintin, E. P. Reich, K. E. Swenson, R. A. Flavell, C. A. Janeway

Publikováno v: Diabetes. 44:326-329

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::70306bf3c76b9036caaf20e82f040765
https://doi.org/10.2337/diabetes.44.3.326

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Superantigen-like properties of an antibody bispecific for MHC class II molecules and the V beta domain of the T cell antigen receptor

Autor: J Yagi, M Nakata, T Uchiyama, M Nishikawa, Y Mizushima, K Nishioka, K Ito, H Yagita, K Okumura, C A Janeway

Publikováno v: The Journal of Immunology. 152:3833-3841

A working model for the action of superantigens (SAg) is that they are simple proteins having binding sites for both MHC class II molecules and the V beta domain of the TCR. Binding of a SAg to both molecules cross-links the TCR, inducing a biologic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d966bd4ced90da98789188077e7c61a3
https://doi.org/10.4049/jimmunol.152.8.3833

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Stimulator cell type influences the response of T cells to staphylococcal enterotoxins

Autor: J Yagi, T Uchiyama, C A Janeway

Publikováno v: The Journal of Immunology. 152:1154-1162

Responses to the superantigen Mls are characterized by proliferation of a significant percentage of T cells expressing receptors encoded by one or a few V beta gene segments. Apparently similar responses are elicited by the staphylococcal enterotoxin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::75a3dc333e9222eb18f626628df5183e
https://doi.org/10.4049/jimmunol.152.3.1154

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The mouse mammary tumor virus envelope gene product is required for superantigen presentation to T cells

Autor: Tatyana V. Golovkina, C A Janeway, Alexander V. Chervonsky, Susan R. Ross, J A Prescott

Publikováno v: The Journal of Experimental Medicine

Transgenic mice expressing either the mouse mammary tumor virus (MMTV) superantigen gene (sag) alone or in combination with the viral envelope genes (env) (LEL), or all of the viral genes (gag, pol, env, and sag) (HYB PRO), deleted V beta 14+ T cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a03f4cda46983e61a753299ea9cb871
https://doi.org/10.1084/jem.179.2.439

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TCR-CD4 and TCR-TCR interactions as distinctive mechanisms for the induction of increased intracellular calcium in T-cell signalling

Autor: C H Wolff, S C Hong, H von Grafenstein, C A Janeway

Publikováno v: The Journal of Immunology. 151:1337-1345

Specific activation of CD4 T cells involves recognition of a peptide: MHC class II complex by the heterodimeric alpha beta TCR and its CD4 co-receptor. The activation of T cells initiates a signal transduction cascade that includes a substantial and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1fefeaacf221b5b0d23000336241a60f
https://doi.org/10.4049/jimmunol.151.3.1337

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