Výsledky vyhledávání - "C A, Bartlett"

Akademický článek

Plant cysteine oxidases are dioxygenases that directly enable arginyl transferase-catalysed arginylation of N-end rule targets

Autor: Mark D. White, Maria Klecker, Richard J. Hopkinson, Daan A. Weits, Carolin Mueller, Christin Naumann, Rebecca O’Neill, James Wickens, Jiayu Yang, Jonathan C. Brooks-Bartlett, Elspeth F. Garman, Tom N. Grossmann, Nico Dissmeyer, Emily Flashman

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)

The N-end rule pathway targets substrate proteins for proteasomal degradation. Here, Whiteet al. show that ArabidopsisPLANT CYSTEINE OXIDASEs show dioxygenase activity producing Cys-sulfinic acid at the N-terminus of target proteins, which then act a

Externí odkaz: https://doaj.org/article/208c41197c3f40509bc868b20218a21a

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Akademický článek

Ultraviolet photochemical reaction of [Fe(III)(C2O4)3]3− in aqueous solutions studied by femtosecond time-resolved X-ray absorption spectroscopy using an X-ray free electron laser

Autor: Y. Ogi, Y. Obara, T. Katayama, Y.-I. Suzuki, S. Y. Liu, N. C.-M. Bartlett, N. Kurahashi, S. Karashima, T. Togashi, Y. Inubushi, K. Ogawa, S. Owada, M. Rubešová, M. Yabashi, K. Misawa, P. Slavíček, T. Suzuki

Publikováno v: Structural Dynamics, Vol 2, Iss 3, Pp 034901-034901-19 (2015)

Time-resolved X-ray absorption spectroscopy was performed for aqueous ammonium iron(III) oxalate trihydrate solutions using an X-ray free electron laser and a synchronized ultraviolet laser. The spectral and time resolutions of the experiment were 1.

Externí odkaz: https://doaj.org/article/e08ec8eb5eba4b8789323df511480034

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Abstract P6-18-03: Biomarker analysis of CDK 4/6 and endocrine pathways in hormone-receptor positive (HR+) advanced breast cancer (ABC) bone only disease patients: A joint analysis of PALOMA-2 and PALOMA-3 studies

Autor: Eric Gauthier, DJ Slamon, F Andre, Massimo Cristofanilli, C Huang Bartlett, Zhe Zhang, N. Turner, Sherene Loi, S. Loibl, Richard S. Finn, AM DeMichele, HS Rugo, Karen A. Gelmon, Yuan Liu, Véronique Diéras, Carla Giorgetti

Publikováno v: Cancer Research. 79:P6-18

Background: Palbociclib (PAL) in combination with endocrine therapy (ET) is a preferred treatment option for untreated and previously treated patients with hormone receptor–positive (HR+), human epidermal growth factor receptor 2 (HER2)–negative

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1e17294fdb0a9ab615dcea0439e3b9ce
https://doi.org/10.1158/1538-7445.sabcs18-p6-18-03

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Palbociclib in combination with endocrine therapy versus capecitabine in hormonal receptor-positive, human epidermal growth factor 2-negative, aromatase inhibitor-resistant metastatic breast cancer: a phase III randomised controlled trial—PEARL

Publikováno v: Dipòsit Digital de la UB
Universidad de Barcelona
Annals of Oncology
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname
Zaguán. Repositorio Digital de la Universidad de Zaragoza
Annals of oncology : official journal of the European Society for Medical Oncology
r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
Zaguán: Repositorio Digital de la Universidad de Zaragoza
Universidad de Zaragoza

BACKGROUND: Palbociclib plus endocrine therapy (ET) is the standard treatment for hormone receptor-positive and human epidermal growth factor receptor 2-negative, metastatic breast cancer (MBC). However, its efficacy has not been compared with that o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51f6348ffb7d8ef8463236763e5a9d56
http://hdl.handle.net/2445/176002

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Laboratory Studies of Vibrational Excitation in O2(a1Δg, v) Involving O2, N2, and CO2

Autor: Tom G. Slanger, Nate C.-M. Bartlett, Eunsook S. Hwang, Konstantinos S. Kalogerakis

Publikováno v: The Journal of Physical Chemistry A. 122:8114-8125

Collisional removal of electronic energy from O2 in the low-lying a1Δg state is typically an extremely slow process for the v = 0 level. In this study, we report results on the deactivation of O2(a...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ac48d332e50372f943d77a98fb3282b2
https://doi.org/10.1021/acs.jpca.8b07469

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RABDAM: quantifying specific radiation damage in individual protein crystal structures

Autor: Elspeth F. Garman, Kathryn L. Shelley, Thomas P. E. Dixon, Jonathan C. Brooks-Bartlett

Publikováno v: Journal of Applied Crystallography

A program to measure the extent of specific radiation damage suffered by an individual protein crystal structure, suitable for running on any standard-format PDB or mmCIF file, is presented.
Radiation damage remains one of the major limitations

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95d74c290cda5be87af1864a2e4cc87e
https://doi.org/10.1107/s1600576718002509

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Abstract P3-11-01: Treatment patterns for young women with HR+/HER2- metastatic breast cancer in the United States in the era of CDK 4/6 inhibitors

Autor: Jack Mardekian, M Fahed Rimawi, Maria Koehler, C Huang Bartlett, Erica L. Mayer, HJ Burstein, Lynn McRoy, J Harnett, AM DeMichele

Publikováno v: Cancer Research. 78:P3-11

Background: NCCN guidelines recommend that premenopausal women with HR+/HER2- metastatic breast cancer (MBC) be rendered postmenopausal and then treated accordingly. After its approval in February 2015, the CDK4/6 inhibitor palbociclib (P), in combin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::75a36ffbc14b0972b789e9877db4ece7
https://doi.org/10.1158/1538-7445.sabcs17-p3-11-01

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Estimate your dose: RADDOSE-3D

Autor: Steven P. Walsh, Jonathan C. Brooks-Bartlett, Charles S. Bury, Elspeth F. Garman

Publikováno v: Protein Science. 27:217-228

We present the current status of RADDOSE-3D, a software tool allowing the estimation of the dose absorbed in a macromolecular crystallography diffraction experiment. The code allows a temporal and spatial dose contour map to be calculated for a cryst

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7733c38f2f3b5f7741aedfc680c44463
https://doi.org/10.1002/pro.3302

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Plant cysteine oxidases are dioxygenases that directly enable arginyl transferase-catalysed arginylation of N-end rule targets

Autor: Emily Flashman, Rebecca O’Neill, Elspeth F. Garman, Nico Dissmeyer, Daan A. Weits, Richard J. Hopkinson, Tom N. Grossmann, Jiayu Yang, James Wickens, Maria Klecker, Jonathan C. Brooks-Bartlett, Christin Naumann, Mark D. White, Carolin Mueller

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
Nature Communications, 8:14690. Nature Publishing Group
Nature Communications 8, 14690 (2017). doi:10.1038/ncomms14690
Nature Communications
White, M D, Klecker, M, Hopkinson, R J, Weits, D A, Mueller, C, Naumann, C, O'Neill, R, Wickens, J, Yang, J, Brooks-Bartlett, J C, Garman, E F, Grossmann, T N, Dissmeyer, N & Flashman, E 2017, ' Plant cysteine oxidases are dioxygenases that directly enable arginyl transferase-catalysed arginylation of N-end rule targets ', Nature Communications, vol. 8, 14690, pp. 14690 . https://doi.org/10.1038/ncomms14690

Crop yield loss due to flooding is a threat to food security. Submergence-induced hypoxia in plants results in stabilization of group VII ETHYLENE RESPONSE FACTORs (ERF-VIIs), which aid survival under these adverse conditions. ERF-VII stability is co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8ea0ac2182dfa82785549fcc2dd73d3
https://doaj.org/article/208c41197c3f40509bc868b20218a21a

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