Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Cǎlin C Guet"'
Autor:
Isabella Tomanek, Călin C Guet
Publikováno v:
eLife, Vol 11 (2022)
Together, copy-number and point mutations form the basis for most evolutionary novelty, through the process of gene duplication and divergence. While a plethora of genomic data reveals the long-term fate of diverging coding sequences and their cis-re
Externí odkaz:
https://doaj.org/article/086639d4c29a43a1a28769db8e7c282d
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 7, p e1007168 (2019)
Mathematical models have been used successfully at diverse scales of biological organization, ranging from ecology and population dynamics to stochastic reaction events occurring between individual molecules in single cells. Generally, many biologica
Externí odkaz:
https://doaj.org/article/59602513deeb4bcaa85bac1e1874c492
Due to their ability to choose between lysis and lysogeny, temperate bacteriophages represent a classic model system to study the molecular basis of decision making. The coinfection of individual bacteria by multiple, genetically identical phages is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b9b5709e143b484353bc3e97a746d30
https://doi.org/10.1101/2020.03.18.996918
https://doi.org/10.1101/2020.03.18.996918
Autor:
Kathrin Tomasek, Alexander Leithner, Ivana Glatzova, Michael S Lukesch, Calin C Guet, Michael Sixt
Publikováno v:
eLife, Vol 11 (2022)
A key attribute of persistent or recurring bacterial infections is the ability of the pathogen to evade the host’s immune response. Many Enterobacteriaceae express type 1 pili, a pre-adapted virulence trait, to invade host epithelial cells and esta
Externí odkaz:
https://doaj.org/article/d82a091bbe6042118c8d19a2e745b23b
Autor:
Mato Lagator, Srdjan Sarikas, Magdalena Steinrueck, David Toledo-Aparicio, Jonathan P Bollback, Calin C Guet, Gašper Tkačik
Publikováno v:
eLife, Vol 11 (2022)
Predicting function from sequence is a central problem of biology. Currently, this is possible only locally in a narrow mutational neighborhood around a wildtype sequence rather than globally from any sequence. Using random mutant libraries, we devel
Externí odkaz:
https://doaj.org/article/50f68b595e8143fc96311c7d7b58db73
Autor:
Anna Nagy-Staron, Kathrin Tomasek, Caroline Caruso Carter, Elisabeth Sonnleitner, Bor Kavčič, Tiago Paixão, Calin C Guet
Publikováno v:
eLife, Vol 10 (2021)
Gene expression levels are influenced by multiple coexisting molecular mechanisms. Some of these interactions such as those of transcription factors and promoters have been studied extensively. However, predicting phenotypes of gene regulatory networ
Externí odkaz:
https://doaj.org/article/df2487ed4b874c41970c4d8b7a0c9edd
Autor:
Waqas N Chaudhry, Maroš Pleška, Nilang N Shah, Howard Weiss, Ingrid C McCall, Justin R Meyer, Animesh Gupta, Călin C Guet, Bruce R Levin
Publikováno v:
PLoS Biology, Vol 16, Iss 8, p e2005971 (2018)
In experimental cultures, when bacteria are mixed with lytic (virulent) bacteriophage, bacterial cells resistant to the phage commonly emerge and become the dominant population of bacteria. Following the ascent of resistant mutants, the densities of
Externí odkaz:
https://doaj.org/article/807252dd11a348919f49f026a58af619
Publikováno v:
eLife, Vol 6 (2017)
Most phenotypes are determined by molecular systems composed of specifically interacting molecules. However, unlike for individual components, little is known about the distributions of mutational effects of molecular systems as a whole. We ask how t
Externí odkaz:
https://doaj.org/article/f3152bb3aae6497dbabc9b9a5e0fa0a2
Autor:
Magdalena Steinrueck, Călin C Guet
Publikováno v:
eLife, Vol 6 (2017)
How the organization of genes on a chromosome shapes adaptation is essential for understanding evolutionary paths. Here, we investigate how adaptation to rapidly increasing levels of antibiotic depends on the chromosomal neighborhood of a drug-resist
Externí odkaz:
https://doaj.org/article/1e4a480e98b7409c8da8e40a08ec89a5
Publikováno v:
eLife, Vol 6 (2017)
Understanding the relation between genotype and phenotype remains a major challenge. The difficulty of predicting individual mutation effects, and particularly the interactions between them, has prevented the development of a comprehensive theory tha
Externí odkaz:
https://doaj.org/article/11bb70c8a0bf4635beec9630e54c7d42