Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Călin C Guet"'
Autor:
Isabella Tomanek, Călin C Guet
Publikováno v:
eLife, Vol 11 (2022)
Together, copy-number and point mutations form the basis for most evolutionary novelty, through the process of gene duplication and divergence. While a plethora of genomic data reveals the long-term fate of diverging coding sequences and their cis-re
Externí odkaz:
https://doaj.org/article/086639d4c29a43a1a28769db8e7c282d
Autor:
Waqas N Chaudhry, Maroš Pleška, Nilang N Shah, Howard Weiss, Ingrid C McCall, Justin R Meyer, Animesh Gupta, Călin C Guet, Bruce R Levin
Publikováno v:
PLoS Biology, Vol 16, Iss 8, p e2005971 (2018)
In experimental cultures, when bacteria are mixed with lytic (virulent) bacteriophage, bacterial cells resistant to the phage commonly emerge and become the dominant population of bacteria. Following the ascent of resistant mutants, the densities of
Externí odkaz:
https://doaj.org/article/807252dd11a348919f49f026a58af619
Publikováno v:
eLife, Vol 6 (2017)
Most phenotypes are determined by molecular systems composed of specifically interacting molecules. However, unlike for individual components, little is known about the distributions of mutational effects of molecular systems as a whole. We ask how t
Externí odkaz:
https://doaj.org/article/f3152bb3aae6497dbabc9b9a5e0fa0a2
Autor:
Magdalena Steinrueck, Călin C Guet
Publikováno v:
eLife, Vol 6 (2017)
How the organization of genes on a chromosome shapes adaptation is essential for understanding evolutionary paths. Here, we investigate how adaptation to rapidly increasing levels of antibiotic depends on the chromosomal neighborhood of a drug-resist
Externí odkaz:
https://doaj.org/article/1e4a480e98b7409c8da8e40a08ec89a5
Publikováno v:
eLife, Vol 6 (2017)
Understanding the relation between genotype and phenotype remains a major challenge. The difficulty of predicting individual mutation effects, and particularly the interactions between them, has prevented the development of a comprehensive theory tha
Externí odkaz:
https://doaj.org/article/11bb70c8a0bf4635beec9630e54c7d42
Autor:
Thibaud T Renault, Anthony O Abraham, Tobias Bergmiller, Guillaume Paradis, Simon Rainville, Emmanuelle Charpentier, Călin C Guet, Yuhai Tu, Keiichi Namba, James P Keener, Tohru Minamino, Marc Erhardt
Publikováno v:
eLife, Vol 6 (2017)
The bacterial flagellum is a self-assembling nanomachine. The external flagellar filament, several times longer than a bacterial cell body, is made of a few tens of thousands subunits of a single protein: flagellin. A fundamental problem concerns the
Externí odkaz:
https://doaj.org/article/0d8e4e5410504d0ea3fe009f4a0d60a1
Autor:
Ali Kinkhabwala, Călin C Guet
Publikováno v:
PLoS ONE, Vol 3, Iss 4, p e2030 (2008)
Revealing the spectrum of combinatorial regulation of transcription at individual promoters is essential for understanding the complex structure of biological networks. However, the computations represented by the integration of various molecular sig
Externí odkaz:
https://doaj.org/article/ac65475d2d2145a49b1082f9449da3af
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Single cell growth rate variability has been difficult to understand. Here, the authors apply a generalization of flux balance analysis to single cells based on maximum entropy modeling, and find that growth rate fluctuations of E. coli reflect metab
Externí odkaz:
https://doaj.org/article/047a842e2a584521b3b1c31d7ce5b03a
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Individual bacteria interact with each other and their environment to produce population-level patterns of gene expression. Here the authors use an automated platform combined with optogenetic feedback to manipulate population behaviors through dynam
Externí odkaz:
https://doaj.org/article/1fadea4a2a1341e78b4f878004e369cc
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Limited specificity of transcription factor-DNA interactions leads to crosstalk in gene regulation. Here the authors consider global crosstalk in regulatory networks of growing size and complexity, and show that it imposes constraints on gene regulat
Externí odkaz:
https://doaj.org/article/c992d8eba18c4f6c9db2333ee90aa8f3