Výsledky vyhledávání - "Cüneyt Türkeş"

Akademický článek

Synthesis, characterisation, biological evaluation and in silico studies of sulphonamide Schiff bases

Autor: Mustafa Durgun, Cüneyt Türkeş, Mesut Işık, Yeliz Demir, Ali Saklı, Ali Kuru, Abdussamat Güzel, Şükrü Beydemir, Suleyman Akocak, Sameh M. Osman, Zeid AlOthman, Claudiu T. Supuran

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 950-962 (2020)

Sulphonamides are biologically important compounds with low toxicity, many bioactivities and cost-effectiveness. Eight sulphonamide derivatives were synthesised and characterised by FT-IR, 13C NMR, 1H NMR, LC-MS and elemental analysis. Their inhibito

Externí odkaz: https://doaj.org/article/eee04bfa1cfc44a4853cd06f8fde7298

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Novel acetic acid derivatives containing quinazolin‐4(3 H )‐one ring: Synthesis, in vitro, and in silico evaluation of potent aldose reductase inhibitors

Autor: Feyzi Sinan Tokalı, Yeliz Demir, Cüneyt Türkeş, Büşra Dinçer, Şükrü Beydemir

Publikováno v: Drug Development Research. 84:275-295

Aldose reductase (AR) is a crucial enzyme of the polyol pathway through which glucose is metabolized under conditions of hyperglycemia related to diabetes. A series of novel acetic acid derivatives containing quinazolin-4(3H)-one ring (1-22) was synt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48c1cf243413af06519b85894d9e879c
https://doi.org/10.1002/ddr.22031

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Novel 1,3-diaryltriazene-substituted sulfaguanidine derivatives as selective carbonic anhydrase inhibitors: Synthesis, characterization, inhibition effects, and molecular docking studies

Autor: Suleyman Akocak, Nebih Lolak, Hatice Esra Duran, Mesut Işık, Cüneyt Türkeş, Mustafa Durgun, Şükrü Beydemir

Sulfonamide compounds known as human carbonic anhydrase (hCA) inhibitors are used in the treatment of many diseases such as epilepsy, antibacterial glaucoma, various diseases. 1,3-diaryl-substituted triazenes and sulfaguanidine are used for therapeut

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0eebe77f75bad7fe5d08c1b026d857a0
https://doi.org/10.21203/rs.3.rs-2812331/v1

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A new series of hydrazones as small‐molecule aldose reductase inhibitors

Autor: Mehlika D. Altıntop, Yeliz Demir, Cüneyt Türkeş, Remzi B. Öztürk, Zerrin Cantürk, Şükrü Beydemir, Ahmet Özdemir

Publikováno v: Archiv der Pharmazie. 356

In the search for small-molecule aldose reductase (AR) inhibitors, new tetrazole-hydrazone hybrids (1-15) were designed. An efficient procedure was employed for the synthesis of compounds 1-15. All hydrazones were subjected to an in vitro assay to as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29ebc057cd91f12fbed24ad8e51406f5
https://doi.org/10.1002/ardp.202200570

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Exploration of 1,2,3-triazole linked benzenesulfonamide derivatives as isoform selective inhibitors of human carbonic anhydrase

Autor: Chnar Kakakhan, Cüneyt Türkeş, Özcan Güleç, Yeliz Demir, Mustafa Arslan, Gizem Özkemahlı, Şükrü Beydemir

A novel series of 1,2,3-triazole benzenesulfonamide substituted 1,3-dioxoisoindolin-5-carboxylate (7a-l) inhibitors of human α-carbonic anhydrase (hCA) was designed using a tail approach. The design method relies on the hybridization of a benzenesul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2723a52a93114ee1b464e0d000880ffa
https://hdl.handle.net/11552/2976

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Enzyme inhibition, molecular docking, and density functional theory studies of new thiosemicarbazones incorporating the 4‐hydroxy‐3,5‐dimethoxy benzaldehyde motif

Autor: Yeliz Demir, Cüneyt Türkeş, Muhammet S. Çavuş, Musa Erdoğan, Halit Muğlu, Hasan Yakan, Şükrü Beydemir

Publikováno v: Archiv der Pharmazie. 356

New Schiff base-bearing thiosemicarbazones (1-13) were obtained from 4-hydroxy-3,5-dimethoxy benzaldehyde and various isocyanates. The structures of the synthesized molecules were elucidated in detail. Density functional theory calculations were also

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67f2d8988cb48bc8ad0b040306b4bfbd
https://doi.org/10.1002/ardp.202200554

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