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Leishmania Genome Dynamics during Environmental Adaptation Reveal Strain-Specific Differences in Gene Copy Number Variation, Karyotype Instability, and Telomeric Amplification.

Autor: Bussotti G; Institut Pasteur-Bioinformatics and Biostatistics Hub-C3BI, USR 3756 IP CNRS, Paris, France.; Unité de Parasitologiemoléculaire et Signalisation, Institut Pasteur, Paris, France., Gouzelou E; Unité de Parasitologiemoléculaire et Signalisation, Institut Pasteur, Paris, France., Côrtes Boité M; Laboratory on Leishmaniasis Research, Oswaldo Cruz Institute-Fiocruz, Rio de Janeiro, Brazil., Kherachi I; Laboratoire d'Eco-épidémiologieparasitaire et Génétique des Populations, Institut Pasteur d'Algérie, Algiers, Algéria., Harrat Z; Laboratoire d'Eco-épidémiologieparasitaire et Génétique des Populations, Institut Pasteur d'Algérie, Algiers, Algéria., Eddaikra N; Laboratoire d'Eco-épidémiologieparasitaire et Génétique des Populations, Institut Pasteur d'Algérie, Algiers, Algéria., Mottram JC; Centre for Immunology and Infection, Department of Biology, University of York, York, United Kingdom., Antoniou M; Laboratory of Clinical Bacteriology, Parasitology, Zoonoses and Geographical Medicine, School of Medicine, University of Crete, VassilikaVouton, Heraklion, Greece., Christodoulou V; Laboratory of Clinical Bacteriology, Parasitology, Zoonoses and Geographical Medicine, School of Medicine, University of Crete, VassilikaVouton, Heraklion, Greece., Bali A; Laboratory of Transmission, Control and Immunobiology of Infections (LTCII), Institut Pasteur de Tunis, Tunis-Belvédère, Tunisia.; Université Tunis El Manar, Tunis, Tunisia., Guerfali FZ; Laboratory of Transmission, Control and Immunobiology of Infections (LTCII), Institut Pasteur de Tunis, Tunis-Belvédère, Tunisia.; Université Tunis El Manar, Tunis, Tunisia., Laouini D; Laboratory of Transmission, Control and Immunobiology of Infections (LTCII), Institut Pasteur de Tunis, Tunis-Belvédère, Tunisia.; Université Tunis El Manar, Tunis, Tunisia., Mukhtar M; The Institute of Endemic Diseases, University of Khartoum, Khartoum, Sudan., Dumetz F; Molecular Parasitology Unit, Institute of Tropical Medicine, Antwerp, Belgium., Dujardin JC; Molecular Parasitology Unit, Institute of Tropical Medicine, Antwerp, Belgium.; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium., Smirlis D; Molecular Parasitology Laboratory, Microbiology Department, Hellenic Pasteur Institute, Athens, Greece., Lechat P; Institut Pasteur-Bioinformatics and Biostatistics Hub-C3BI, USR 3756 IP CNRS, Paris, France., Pescher P; Unité de Parasitologiemoléculaire et Signalisation, Institut Pasteur, Paris, France., El Hamouchi A; Laboratory of Parasitology and Vector-Borne-Diseases, Institut Pasteur du Maroc, Casablanca, Morocco., Lemrani M; Laboratory of Parasitology and Vector-Borne-Diseases, Institut Pasteur du Maroc, Casablanca, Morocco., Chicharro C; WHO Collaborating Centre for Leishmaniasis, Instituto de Salud Carlos III, Madrid, Spain., Llanes-Acevedo IP; WHO Collaborating Centre for Leishmaniasis, Instituto de Salud Carlos III, Madrid, Spain., Botana L; WHO Collaborating Centre for Leishmaniasis, Instituto de Salud Carlos III, Madrid, Spain., Cruz I; WHO Collaborating Centre for Leishmaniasis, Instituto de Salud Carlos III, Madrid, Spain., Moreno J; WHO Collaborating Centre for Leishmaniasis, Instituto de Salud Carlos III, Madrid, Spain., Jeddi F; Université Tunis El Manar, Tunis, Tunisia.; Research Laboratory Medical Parasitology, Biotechnology and Biomolecules, Institut Pasteur de Tunis, Tunis-Belvédère, Tunisia., Aoun K; Université Tunis El Manar, Tunis, Tunisia.; Research Laboratory Medical Parasitology, Biotechnology and Biomolecules, Institut Pasteur de Tunis, Tunis-Belvédère, Tunisia., Bouratbine A; Université Tunis El Manar, Tunis, Tunisia.; Research Laboratory Medical Parasitology, Biotechnology and Biomolecules, Institut Pasteur de Tunis, Tunis-Belvédère, Tunisia., Cupolillo E; Laboratory on Leishmaniasis Research, Oswaldo Cruz Institute-Fiocruz, Rio de Janeiro, Brazil., Späth GF; Unité de Parasitologiemoléculaire et Signalisation, Institut Pasteur, Paris, France gerald.spaeth@pasteur.fr.

Publikováno v: MBio [mBio] 2018 Nov 06; Vol. 9 (6). Date of Electronic Publication: 2018 Nov 06.