Zobrazeno 1 - 10
of 142
pro vyhledávání: '"César Santiago"'
Autor:
Cristina Martínez, Elisa Iniesto, Marta García-León, Daniel García-Corredera, Sandra Fonseca, César Santiago, Mei Yang, Renbo Yu, Haodong Chen, Eva Altmann, Martin Renatus, Xing Wang Deng, Vicente Rubio
Publikováno v:
Cell Reports, Vol 43, Iss 10, Pp 114802- (2024)
Summary: Phytohormone abscisic acid (ABA) regulates key plant development and environmental stress responses. The ubiquitin-proteasome system tightly controls ABA signaling. CULLIN4-RING (CRL4) E3 ubiquitin ligases use the substrate receptor module C
Externí odkaz:
https://doaj.org/article/79c91f61f5e741bc9e33adf0480acebe
Autor:
Eva M García-Cuesta, Pablo Martínez, Karthik Selvaraju, Gabriel Ulltjärn, Adrián Miguel Gómez Pozo, Gianluca D'Agostino, Sofia Gardeta, Adriana Quijada-Freire, Patricia Blanco Gabella, Carlos Roca, Daniel del Hoyo, Rodrigo Jiménez-Saiz, Alfonso García-Rubia, Blanca Soler Palacios, Pilar Lucas, Rosa Ayala-Bueno, Noelia Santander Acerete, Yolanda Carrasco, Carlos Oscar Sorzano, Ana Martinez, Nuria E Campillo, Lasse D Jensen, Jose Miguel Rodriguez Frade, César Santiago, Mario Mellado
Publikováno v:
eLife, Vol 13 (2024)
CXCR4 is a ubiquitously expressed chemokine receptor that regulates leukocyte trafficking and arrest in both homeostatic and pathological states. It also participates in organogenesis, HIV-1 infection, and tumor development. Despite the potential the
Externí odkaz:
https://doaj.org/article/f6355c90de494368a3bd46842c4d4614
Autor:
Leire de Campos-Mata, Benjamin Trinité, Andrea Modrego, Sonia Tejedor Vaquero, Edwards Pradenas, Anna Pons-Grífols, Natalia Rodrigo Melero, Diego Carlero, Silvia Marfil, César Santiago, Dàlia Raïch-Regué, María Teresa Bueno-Carrasco, Ferran Tarrés-Freixas, Ferran Abancó, Victor Urrea, Nuria Izquierdo-Useros, Eva Riveira-Muñoz, Ester Ballana, Mónica Pérez, Júlia Vergara-Alert, Joaquim Segalés, Carlo Carolis, Rocío Arranz, Julià Blanco, Giuliana Magri
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Here we report the characterization of 17T2, a SARS-CoV-2 pan-neutralizing human monoclonal antibody isolated from a COVID-19 convalescent individual infected during the first pandemic wave. 17T2 is a class 1 VH1-58/κ3-20 antibody, derived
Externí odkaz:
https://doaj.org/article/e88c94774f434c16bec8caaf30b4258f
Autor:
Lorea Velasco-Carneros, Jorge Cuéllar, Leire Dublang, César Santiago, Jean-Didier Maréchal, Jaime Martín-Benito, Moisés Maestro, José Ángel Fernández-Higuero, Natalia Orozco, Fernando Moro, José María Valpuesta, Arturo Muga
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract J-domain proteins tune the specificity of Hsp70s, engaging them in precise functions. Despite their essential role, the structure and function of many J-domain proteins remain largely unknown. We explore human DNAJA2, finding that it reversi
Externí odkaz:
https://doaj.org/article/6cd9508201a643d8a30f5d1e3bb400ad
Autor:
Lorea Velasco-Carneros, Jorge Cuéllar, Leire Dublang, César Santiago, Jean-Didier Maréchal, Jaime Martín-Benito, Moisés Maestro, José Ángel Fernández-Higuero, Natalia Orozco, Fernando Moro, José María Valpuesta, Arturo Muga
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/a222e6ad375d4e16b18188f55f5314a6
Autor:
María Teresa Bueno-Carrasco, Jorge Cuéllar, Marte I. Flydal, César Santiago, Trond-André Kråkenes, Rune Kleppe, José R. López-Blanco, Miguel Marcilla, Knut Teigen, Sara Alvira, Pablo Chacón, Aurora Martinez, José M. Valpuesta
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Tyrosine hydroxylase (TH) catalyzes the rate-limiting step in the synthesis of the catecholamine neurotransmitters and hormones dopamine (DA), adrenaline and noradrenaline. Here, the authors present the cryo-EM structures of full-length human TH in t
Externí odkaz:
https://doaj.org/article/3b54c91d09444b37ba25ca02cc815dcd
Autor:
José M. Rojas, Elena Pascual, Sean R. Wattegedera, Miguel Avia, César Santiago, Verónica Martín, Gary Entrican, Noemí Sevilla
Publikováno v:
Virulence, Vol 12, Iss 1, Pp 690-703 (2021)
The toll-like receptor (TLR) family comprises both cell-surface and intracellular receptors that recognize different types of pathogen-associated molecular patterns (PAMPs) leading to the production of pro-inflammatory cytokines and subsequent develo
Externí odkaz:
https://doaj.org/article/54609e2379184109b7f85cb10c7cba7b
Autor:
Jorge Cuéllar, W. Grant Ludlam, Nicole C. Tensmeyer, Takuma Aoba, Madhura Dhavale, César Santiago, M. Teresa Bueno-Carrasco, Michael J. Mann, Rebecca L. Plimpton, Aman Makaju, Sarah Franklin, Barry M. Willardson, José M. Valpuesta
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
β-propeller domains are an important class of folding substrates for the eukaryotic cytosolic chaperonin CTT. Here the authors find that CTT contributes to the folding and assembly of two β-propeller proteins from mTOR complexes, mLST8 and Raptor,
Externí odkaz:
https://doaj.org/article/23eeb432bf314670b0ab58f513d2d7e9
Autor:
Suresh C. Raman, Ernesto Mejías-Pérez, Carmen E. Gomez, Juan García-Arriaza, Beatriz Perdiguero, Aneesh Vijayan, Mar Pérez-Ruiz, Ana Cuervo, César Santiago, Carlos Oscar S. Sorzano, Cristina Sánchez-Corzo, Christiane Moog, Judith A. Burger, Anna Schorcht, Rogier W. Sanders, José L. Carrascosa, Mariano Esteban
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
There is an urgent need for the development of potent vaccination regimens that are able to induce specific T and B cell responses against human immunodeficiency virus type 1 (HIV-1). Here, we describe the generation and characterization of a fusion
Externí odkaz:
https://doaj.org/article/cd061f2f0dd048dba72f3844b70d364d
Autor:
Dante Barreda, César Santiago, Juan R. Rodríguez, José F. Rodríguez, José M. Casasnovas, Isabel Mérida, Antonia Ávila-Flores
Publikováno v:
Cells, Vol 10, Iss 12, p 3279 (2021)
Dendritic cells (DCs) are the most potent antigen-presenting cells, and their function is essential to configure adaptative immunity and avoid excessive inflammation. DCs are predicted to play a crucial role in the clinical evolution of the infection
Externí odkaz:
https://doaj.org/article/1cc22a90ca72488ebde99fd22d619635