Zobrazeno 1 - 10
of 31
pro vyhledávání: '"César S. Mendes"'
Autor:
Diogo Carregosa, Natasa Loncarevic-Vasiljkovic, Raquel Feliciano, Diogo Moura-Louro, César S. Mendes, Cláudia Nunes dos Santos
Publikováno v:
Journal of Inflammation, Vol 21, Iss 1, Pp 1-16 (2024)
Abstract Lipopolysaccharide (LPS) challenge in mice has been used to identify the mechanisms and therapeutics for neuroinflammation. In this study, we aimed to comprehensively evaluate the behavioral changes including locomotion, exploration, and mem
Externí odkaz:
https://doaj.org/article/a0e8743a6e014cfd91fcc1f540c839fd
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Wired neurons form new presynaptic boutons in response to increased synaptic activity, however the mechanism(s) by which this occurs remains uncertain. Drosophila motor neurons (MNs) have clearly discernible boutons that display robust struc
Externí odkaz:
https://doaj.org/article/9528b35b5b8648d5a8e2d2e28631f6bc
Autor:
Rita Rosado-Ramos, Gonçalo M. Poças, Daniela Marques, Alexandre Foito, David M. Sevillano, Mafalda Lopes-da-Silva, Luís G. Gonçalves, Regina Menezes, Marcel Ottens, Derek Stewart, Alain Ibáñez de Opakua, Markus Zweckstetter, Miguel C. Seabra, César S. Mendes, Tiago Fleming Outeiro, Pedro M. Domingos, Cláudia N. Santos
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
In this work, the authors identify Genipin as a small iridoid able to prevent alpha-synuclein aggregation and toxicity by affecting endocytosis, metabolism and lipid storage.
Externí odkaz:
https://doaj.org/article/6e0052eb0e2b432c9b02cba0d241c7e9
Autor:
Fabiana Heredia, Yanel Volonté, Joana Pereirinha, Magdalena Fernandez-Acosta, Andreia P. Casimiro, Cláudia G. Belém, Filipe Viegas, Kohtaro Tanaka, Juliane Menezes, Maite Arana, Gisele A. Cardoso, André Macedo, Malwina Kotowicz, Facundo H. Prado Spalm, Marcos J. Dibo, Raquel D. Monfardini, Tatiana T. Torres, César S. Mendes, Andres Garelli, Alisson M. Gontijo
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Pupariation in Drosophila is triggered by the steroid-hormone ecdysone and requires coordination between associated behavioral and body-reshaping motor subprograms. The authors show that coordination requires ecdysone-dependent Dilp8-Lgr3 signaling b
Externí odkaz:
https://doaj.org/article/f822d3a3ff054af8a43f277e88d9af21
Autor:
Ana Cabrita, Alexandra M. Medeiros, Telmo Pereira, António Sebastião Rodrigues, Michel Kranendonk, César S. Mendes
Publikováno v:
iScience, Vol 25, Iss 7, Pp 104541- (2022)
Summary: Adequate alternatives to conventional animal testing are needed to study developmental neurotoxicity (DNT). Here, we used kinematic analysis to assess DNT of known (toluene (TOL) and chlorpyrifos (CPS)) and putative (β-N-methylamino-L-alani
Externí odkaz:
https://doaj.org/article/472de6d11e1f4a76857f1b46db1db26d
Autor:
Ana Filipa Isidro, Alexandra M. Medeiros, Isaura Martins, Dalila Neves-Silva, Leonor Saúde, César S. Mendes
Publikováno v:
Journal of Visualized Experiments.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::645650ad6a25e57acb6f22381112de45
https://doi.org/10.3791/65207
https://doi.org/10.3791/65207
Most vertebrates and invertebrates such as Drosophila melanogaster are able to move in complex environments due to their ability to integrate sensory information along with motor commands. Mechanosensory structures exist along each leg to assist in m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c6db614c9322854aa757cee2b5398078
https://doi.org/10.1101/2022.07.19.500315
https://doi.org/10.1101/2022.07.19.500315
Autor:
Ana, Cabrita, Alexandra M, Medeiros, Telmo, Pereira, António Sebastião, Rodrigues, Michel, Kranendonk, César S, Mendes
Publikováno v:
iScience. 25(7)
Adequate alternatives to conventional animal testing are needed to study developmental neurotoxicity (DNT). Here, we used kinematic analysis to assess DNT of known (toluene (TOL) and chlorpyrifos (CPS)) and putative (β-N-methylamino-L-alanine (BMAA)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1d9220420b678191bd886536501b7bc8
https://pubmed.ncbi.nlm.nih.gov/35769875
https://pubmed.ncbi.nlm.nih.gov/35769875
Autor:
António Sebastião Rodrigues, Alexandra Medeiros, César S. Mendes, Michel Kranendonk, Ana Cabrita, Telmo Pereira
Humans interact with numerous chemical compounds with direct health implications, with several able to induce developmental neurotoxicity (DNT), which bear developmental, behavioral, and cognitive consequences from a young age. Current guidelines for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87a5a8262d39ab6c26b3b6f6f8a90e63
https://doi.org/10.1101/2021.07.09.451676
https://doi.org/10.1101/2021.07.09.451676
Autor:
António Sebastião Rodrigues, Michel Kranendonk, Telmo Pereira, Ana Cabrita, Alexandra Medeiros, César S. Mendes
Publikováno v:
iScience. 25:104541
752891, GEMiNI to CSM), Fundac¸ a˜ o para a Cieˆ ncia e a Tecnologia (FCT) (PTDC/ BIA-COM/0151/2020, iNOVA4Health (UIDB/04462/2020 and UIDP/04462/2020), and LS4FUTURE (LA/P/ 0087/2020) to CSM). AM was supported by a doctoral fellowship from FCT (P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::514777bd1afb41b54b4bb071601181ed
https://doi.org/10.1016/j.isci.2022.104541
https://doi.org/10.1016/j.isci.2022.104541