Výsledky vyhledávání - "César Oyarce"

Akademický článek

Predictive biomarkers for response to TGF- β inhibition in resensitizing chemo(radiated) esophageal adenocarcinoma

Autor: Dajia Liu, Amber P. van der Zalm, Jan Koster, Sanne Bootsma, Cesar Oyarce, Hanneke W.M. van Laarhoven, Maarten F. Bijlsma

Publikováno v: Pharmacological Research, Vol 207, Iss , Pp 107315- (2024)

Epithelial-mesenchymal transition (EMT) has been identified as a driver of therapy resistance, particularly in esophageal adenocarcinoma (EAC), where transforming growth factor beta (TGF-β) can induce this process. Inhibitors of TGF-β may counterac

Externí odkaz: https://doaj.org/article/693617776d904183909d7cef03180eb3

Zobrazit plný text záznamu

Akademický článek

Hyaluronidase improves the efficacy of nab-paclitaxel after prolonged angiogenesis inhibition in preclinical models for esophagogastric cancer

Autor: Dajia Liu, Lihui Guo, Cynthia Waasdorp, Sybren L. Meijer, Sanne Bootsma, Cesar Oyarce, Maarten F. Bijlsma, Hanneke W.M. van Laarhoven

Publikováno v: Biomedicine & Pharmacotherapy, Vol 178, Iss , Pp 117261- (2024)

Background: Long-term anti-angiogenesis leads to pruned vasculature, densely deposited extracellular matrix (ECM), and consequently reduced chemotherapy delivery in esophagogastric cancer (EGC). To address this issue, we evaluated the efficacy of add

Externí odkaz: https://doaj.org/article/4443b6f6d2ae4872bc3299247fbd9f68

Zobrazit plný text záznamu

Abstract 4008: Transcriptomic signatures in esophageal adenocarcinoma define distinct subtypes with therapeutic relevance

Autor: Mark P.G. Dings, Amber P. Zalm, Marjolein F. Lansbergen, César Oyarce, Sybren L. Meijer, Cynthia Waasdorp, Jan Paul Medema, Hanneke van Laarhoven, Maarten F. Bijlsma

Publikováno v: Cancer Research. 82:4008-4008

Background & Aims: Esophageal cancer is the fifth most common solid cancer globally, and esophageal adenocarcinoma (EAC) is the predominant histological subtype in the western world. Patients often present at an advanced stage and overall-5-year surv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::39b942b29d33dfc9e944cada45e5e0da
https://doi.org/10.1158/1538-7445.am2022-4008

Zobrazit plný text záznamu

Abstract 2616: Stemness factors nanog and oct4 contribute to epithelial-to-mesenchymal transition and are predictive for outcome in esophageal adenocarcinoma

Autor: Amber Perenna van der Zalm, Mark P. Dings, Reimer Janssen, Peter Bailey, Jan Koster, Danny Zwijnenburg, Richard Volckmann, Cynthia Waasdorp, Jeroen Blokhuis, César Oyarce, Gerrit Hooijer, Sybren L. Meijer, Jan Paul Medema, Hanneke W. van Laarhoven, Maarten F. Bijlsma

Publikováno v: Cancer Research. 82:2616-2616

Background and Aims: The incidence of esophageal adenocarcinoma (EAC) has increased six-fold in Western countries over the last decades, and 5-year survival rates remain low at 5-20%. While multimodality treatment strategies for curative treatment of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5fe3e9a0eac02d97050119aa43000785
https://doi.org/10.1158/1538-7445.am2022-2616

Zobrazit plný text záznamu

Akademický článek

Re-polarization of immunosuppressive macrophages to tumor-cytotoxic macrophages by repurposed metabolic drugs

Autor: Cesar Oyarce, Ana Vizcaino-Castro, Shipeng Chen, Annemarie Boerma, Toos Daemen

Publikováno v: OncoImmunology, Vol 10, Iss 1 (2021)

M2-like tumor-associated macrophages promote tumor progression by establishing an immunosuppressive tumor microenvironment. The phenotype and activity of immunosuppressive macrophages are related to their mitochondrial metabolism. Thus, we studied if

Externí odkaz: https://doaj.org/article/3ed9264caad847f1bfb6a4280ff40acd

Zobrazit plný text záznamu

Akademický článek

Caveolin-1 Expression Increases upon Maturation in Dendritic Cells and Promotes Their Migration to Lymph Nodes Thereby Favoring the Induction of CD8+ T Cell Responses

Autor: Cesar Oyarce, Sebastián Cruz-Gomez, Felipe Galvez-Cancino, Pablo Vargas, Hélène D. Moreau, Natalia Diaz-Valdivia, Jorge Diaz, Flavio Andres Salazar-Onfray, Rodrigo Pacheco, Ana Maria Lennon-Dumenil, Andrew F. G. Quest, Alvaro Lladser

Publikováno v: Frontiers in Immunology, Vol 8 (2017)

Dendritic cell (DC) trafficking from peripheral tissues to lymph nodes (LNs) is a key step required to initiate T cell responses against pathogens as well as tumors. In this context, cellular membrane protrusions and the actin cytoskeleton are essent

Externí odkaz: https://doaj.org/article/975fb8be8c604d48ab5f793da7273674

Zobrazit plný text záznamu

Akademický článek

GSK-3β/NFAT Signaling Is Involved in Testosterone-Induced Cardiac Myocyte Hypertrophy.

Autor: Javier Duran, Cesar Oyarce, Mario Pavez, Denisse Valladares, Carla Basualto-Alarcon, Daniel Lagos, Genaro Barrientos, Mayarling Francisca Troncoso, Cristian Ibarra, Manuel Estrada

Publikováno v: PLoS ONE, Vol 11, Iss 12, p e0168255 (2016)

Testosterone induces cardiac hypertrophy through a mechanism that involves a concerted crosstalk between cytosolic and nuclear signaling pathways. Nuclear factor of activated T-cells (NFAT) is associated with the promotion of cardiac hypertrophy, gly

Externí odkaz: https://doaj.org/article/03b59a909e3b4bae98ff01b7473c2ce0

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání