Zobrazeno 1 - 6 of 6 pro vyhledávání: '"Céline van der Putten"'
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Akademický článek
Exposure of Microglia to Interleukin-4 Represses NF-κB-Dependent Transcription of Toll-Like Receptor-Induced Cytokines
Autor: Ella A. Zuiderwijk-Sick, Céline van der Putten, Raissa Timmerman, Jennifer Veth, Erica M. Pasini, Linda van Straalen, Paul van der Valk, Sandra Amor, Jeffrey J. Bajramovic
Publikováno v: Frontiers in Immunology, Vol 12 (2021)
Interleukin (IL)-4 is a cytokine that affects both adaptive and innate immune responses. In the central nervous system, microglia express IL-4 receptors and it has been described that IL-4-exposed microglia acquire anti-inflammatory properties. We he
Externí odkaz: https://doaj.org/article/000ca16e7f24436986f08d1b1ba48e40
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2
TLR-Induced IL-12 and CCL2 Production by Myeloid Cells Is Dependent on Adenosine A
Autor: Céline, van der Putten, Jennifer, Veth, Lejla, Sukurova, Ella A, Zuiderwijk-Sick, Elles, Simonetti, Hans J P M, Koenen, Saskia M, Burm, Johannes M, van Noort, Ad P, IJzerman, Sacha A F T, van Hijum, Dimitri, Diavatopoulos, Jeffrey J, Bajramovic
Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 202(8)
TLR-induced signaling potently activates cells of the innate immune system and is subject to regulation at different levels. Inflammatory conditions are associated with increased levels of extracellular adenosine, which can modulate TLR-induced produ
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0a923c8ffb96fc620df25cd372e1efde
https://pubmed.ncbi.nlm.nih.gov/30804043
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3
Inflammasome-Induced IL-1β Secretion in Microglia Is Characterized by Delayed Kinetics and Is Only Partially Dependent on Inflammatory Caspases
Autor: Ella A. Zuiderwijk-Sick, Jennifer Veth, Céline van der Putten, Anke E.J. ‘t Jong, Saskia M. Burm, Jeffrey J. Bajramovic, Ivanela Kondova
Publikováno v: The Journal of Neuroscience. 35:678-687
Inflammasomes are multiprotein complexes that link pathogen recognition and cellular stress to the processing of the proinflammatory cytokine interleukin-1β (IL-1β). Whereas inflammasome-mediated activation is heavily studied in hematopoietic macro
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::538a0a9b7b7c1a20c1d778b234f5c9f0
https://doi.org/10.1523/jneurosci.2510-14.2015
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4
Statins amplify TLR-induced responses in microglia via inhibition of cholesterol biosynthesis
Autor: Ella A. Zuiderwijk-Sick, Céline van der Putten, Linda van Straalen, Hedwich F. Kuipers, Peter J. van den Elsen, Jeffrey J. Bajramovic, Ivanela Kondova
Publikováno v: Glia
GLIA, 60(1), 43-52. John Wiley and Sons Inc.
van der Putten, C, Kuipers, H F, Zuiderwijk-Sick, E A, Stralen, L, Kondova, I, van den Elsen, P J & Bajramovic, J J 2012, ' Statins amplify TLR-induced responses in microglia via inhibition of cholesterol biosynthesis ', GLIA, vol. 60, no. 1, pp. 43-52 . https://doi.org/10.1002/glia.21245
Glia, 60(1), 43-52
Statins inhibit the endogenous intracellular mevalonate pathway and exposure to statins affects innate and adaptive immune responses. Different statins are currently under evaluation as (co)therapy in neuro-inflammatory diseases like multiple scleros
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29e8dcbf92e659b8a4b8d84fb9a7a098
https://doi.org/10.1002/glia.21245
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5
Differentiation of primary adult microglia alters their response to TLR8-mediated activation but not their capacity as APC
Autor: Willem de Boer, Céline van der Putten, Leonie A. Boven, Ilona P. Deuzing, Johannes M. van Noort, Ella A. Zuiderwijk-Sick, C. Persoon-Deen, Bert A. 't Hart, Sandra Amor, Ivanela Kondova, Malika Bsibsi, Jeffrey J. Bajramovic
Publikováno v: Zuiderwijk-Sick, E A, van der Putten, C, Bsibsi, M, Deuzing, I P, de Boer, W, Persoon-Deen, C, Kondova, I, Boven, L A, van Noort, J M, 't Hart, B A, Amor, S & Bajramovic, J J 2007, ' Differentiation of primary adult microglia alters their response to TLR8-mediated activation but not their capacity as APC ', GLIA, vol. 55, no. 15, pp. 1589-600 . https://doi.org/10.1002/glia.20572
GLIA, 15, 55, 1589-1600
GLIA, 55(15), 1589-600. John Wiley and Sons Inc.
GLIA, 55(15), 1589-1600. John Wiley & Sons Inc.
Activated microglia are found in a variety of neuroinflammatory disorders where they have attributed roles as effector as well as antigen-presenting cells (APC). Critical determinants for the multifaceted role of microglia are the differentiation pot
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4003a3a436bda8cb4126d0230cf90e8f
https://research.vumc.nl/en/publications/dde429fb-972f-4566-a2cd-e2edfab19ebb
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