Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Céline Simonin"'
Autor:
Tin Manh Ho, Stephan Berger, Philipp Müller, Céline Simonin, Jean-Louis Reymond, Christoph von Ballmoos, Daniel G. Fuster
Publikováno v:
CHIMIA, Vol 76, Iss 12 (2022)
NHA2, also known as SLC9B2, is an orphan intracellular Na+/H+ exchanger (NHE) that has been associated with arterial hypertension and diabetes mellitus in humans. The objective of this NCCR TransCure project was to define the physiological and molecu
Externí odkaz:
https://doaj.org/article/fd6fcc47e6ba4df08457732160774ec5
Autor:
Di Zhu, Sandra Johannsen, Tiziana Masini, Céline Simonin, Jörg Haupenthal, Boris Illarionov, Anastasia Andreas, Mahendra Awale, Robin M. Gierse, Tridia van der Laan, Ramon van der Vlag, Rita Nasti, Mael Poizat, Eric Buhler, Norbert Reiling, Rolf Müller, Markus Fischer, Jean-Louis Reymond, Anna K. H. Hirsch
Publikováno v:
Chemical Science, 13(36), 10686-10698. ROYAL SOC CHEMISTRY
Zhu, Di; Johannsen, Sandra; Masini, Tiziana; Simonin, Céline; Haupenthal, Jörg; Illarionov, Boris; Andreas, Anastasia; Awale, Mahendra; Gierse, Robin M; van der Laan, Tridia; van der Vlag, Ramon; Nasti, Rita; Poizat, Mael; Buhler, Eric; Reiling, Norbert; Müller, Rolf; Fischer, Markus; Reymond, Jean-Louis; Hirsch, Anna K H (2022). Discovery of novel drug-like antitubercular hits targeting the MEP pathway enzyme DXPS by strategic application of ligand-based virtual screening. Chemical Science, 13(36), pp. 10686-10698. The Royal Society of Chemistry 10.1039/d2sc02371g
Zhu, Di; Johannsen, Sandra; Masini, Tiziana; Simonin, Céline; Haupenthal, Jörg; Illarionov, Boris; Andreas, Anastasia; Awale, Mahendra; Gierse, Robin M; van der Laan, Tridia; van der Vlag, Ramon; Nasti, Rita; Poizat, Mael; Buhler, Eric; Reiling, Norbert; Müller, Rolf; Fischer, Markus; Reymond, Jean-Louis; Hirsch, Anna K H (2022). Discovery of novel drug-like antitubercular hits targeting the MEP pathway enzyme DXPS by strategic application of ligand-based virtual screening. Chemical Science, 13(36), pp. 10686-10698. The Royal Society of Chemistry 10.1039/d2sc02371g
In the present manuscript, we describe how we successfully used ligand-based virtual screening (LBVS) to identify two small-molecule, drug-like hit classes with excellent ADMET profiles against the difficult to address microbial enzyme 1-deoxy-D-xylu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d037a73a79e9b4607948d4bb961dcdb1
https://research.rug.nl/en/publications/47d91e4b-c3e0-48f1-b774-6f2c690412a0
https://research.rug.nl/en/publications/47d91e4b-c3e0-48f1-b774-6f2c690412a0
Autor:
Matthias Rubin, Hugues Abriel, Daniela Ross-Kaschitza, Céline Simonin, Urs Thomet, Sven Kappel, Beatrice Bianchi, Jean-Louis Reymond, Martin Lochner, Clémence Delalande, Lijo Cherian Ozhathil, Christine Peinelt, Gabor Nemeth, Jürg Gertsch
Publikováno v:
British Journal of Pharmacology. 175:2504-2519
Background and purpose TRPM4 is a calcium-activated non-selective cation channel expressed in many tissues and implicated in several diseases, and has not yet been validated as a therapeutic target due to the lack of potent and selective inhibitors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::61a528f23a242ea80643c63951afcaad
https://doi.org/10.1111/bph.14220
https://doi.org/10.1111/bph.14220
Publikováno v:
Journal of Food Science. 81:T2099-T2106
Since the early 2000s, labeling of potentially allergenic food components to protect people who suffer from food allergies is compulsory in numerous industrialized countries. In Europe, milk and egg components used during the winemaking process must
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d1ddffa70badc9fc2c51ec38a9279fa
https://doi.org/10.1111/1750-3841.13378
https://doi.org/10.1111/1750-3841.13378
Autor:
Gergely Kovacs, Roch-Philippe Charles, Abilashan Sithampari, Céline Simonin, Pascal Häfliger, Mahendra Awale, Julian Schwartz, Ruud van Deursen, Gergely Gyimesi, Michael Brand, Matthias A. Hediger, Michael Fine, Jean-Louis Reymond
Publikováno v:
Angewandte Chemie (International ed. in English)
Herein, we report the discovery of the first potent and selective inhibitor of TRPV6, a calcium channel overexpressed in breast and prostate cancer, and its use to test the effect of blocking TRPV6-mediated Ca(2+)-influx on cell growth. The inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1b33646be584a92ce21c38ab5067c5a
Autor:
Lijo Cherian, Ozhathil, Clémence, Delalande, Beatrice, Bianchi, Gabor, Nemeth, Sven, Kappel, Urs, Thomet, Daniela, Ross-Kaschitza, Céline, Simonin, Matthias, Rubin, Jürg, Gertsch, Martin, Lochner, Christine, Peinelt, Jean-Louis, Reymond, Hugues, Abriel
Publikováno v:
British journal of pharmacology. 175(12)
TRPM4 is a calcium-activated non-selective cation channel expressed in many tissues and implicated in several diseases, and has not yet been validated as a therapeutic target due to the lack of potent and selective inhibitors. We sought to discover a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6f849d9cd21f2f65d4452a8a55f568d8
https://pubmed.ncbi.nlm.nih.gov/29579323
https://pubmed.ncbi.nlm.nih.gov/29579323
Autor:
Mahendra Awale, Céline Simonin, Nicolas Montalbetti, Matthias A. Hediger, Alexandre Simonin, Jean-Louis Reymond
Publikováno v:
Biochemical pharmacology. 96(3)
Divalent metal transporter-1 (SLC11A2/DMT1) uses the H(+) electrochemical gradient as the driving force to transport divalent metal ions such as Fe(2+), Mn(2+) and others metals into mammalian cells. DMT1 is ubiquitously expressed, most notably in pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6836c0bd499426e073ccf6c2f09d4a0
https://pubmed.ncbi.nlm.nih.gov/26047847
https://pubmed.ncbi.nlm.nih.gov/26047847