Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Céline Portal"'
Autor:
Juliette Pulman, Catherine Botto, Hugo Malki, Duohao Ren, Paul Oudin, Anne De Cian, Marie As, Charlotte Izabelle, Bruno Saubamea, Valerie Forster, Stéphane Fouquet, Camille Robert, Céline Portal, Aziz El-Amraoui, Sylvain Fisson, Jean-Paul Concordet, Deniz Dalkara
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 4, Pp 102349- (2024)
Genome editing by CRISPR-Cas holds promise for the treatment of retinal dystrophies. For therapeutic gene editing, transient delivery of CRISPR-Cas9 is preferable to viral delivery which leads to long-term expression with potential adverse consequenc
Externí odkaz:
https://doaj.org/article/79b809bb916648639568bb98681ed82b
Autor:
Céline Portal, Yvonne Lin, Varuni Rastogi, Cornelia Peterson, Samuel Chi-Hung Yiu, James W. Foster, Amber Wilkerson, Igor A. Butovich, Carlo Iomini
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-14 (2023)
Meibomian gland (MG) cells are ciliated in early stages of development and primary cilium is required to regulate early MG cell patterning within developing glands, with cilia-mediated signaling pathways identified as therapeutic targets.
Externí odkaz:
https://doaj.org/article/1c246975864b4059b4eaf087504751f5
Publikováno v:
eLife, Vol 8 (2019)
Defects affecting tissues of the anterior segment (AS) of the eye lead to a group of highly debilitating disorders called Anterior Segment Dysgenesis (ASD). Despite the identification of some causative genes, the pathogenesis of ASD remains unclear.
Externí odkaz:
https://doaj.org/article/72955caf2218433da7051a52cd628c0a
Long-term dietary (n-3) polyunsaturated fatty acids show benefits to the lungs of Cftr F508del mice.
Autor:
Céline Portal, Valérie Gouyer, Renaud Léonard, Marie-Odile Husson, Frédéric Gottrand, Jean-Luc Desseyn
Publikováno v:
PLoS ONE, Vol 13, Iss 6, p e0197808 (2018)
INTRODUCTION:The pro-inflammatory status of cystic fibrosis (CF) patients promotes pulmonary colonization with opportunist and pathogenic bacteria, which is favored by a sticky mucus. Oral supplementation with (n-3) long chain polyunsaturated fatty a
Externí odkaz:
https://doaj.org/article/5f1076ab350349fb9be500e917628160
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0174764 (2017)
PURPOSE:Modification of mucous cell density and gel-forming mucin production are established hallmarks of mucosal diseases. Our aim was to develop and validate a mouse model to study live goblet cell density in pathological situations and under pharm
Externí odkaz:
https://doaj.org/article/388cb87e01fe41f4bb94dc868c8e39f2
Autor:
Céline Portal, Yvonne Lin, Varuni Rastogi, Cornelia Peterson, Samuel Yiu, James Foster, Amber Wilkerson, Igor Butovich, Carlo Iomini
Meibomian glands (MGs) are modified sebaceous glands which produce the tear film's lipid component. Despite their critical function in maintaining clear vision, the mechanisms underlying MG morphogenesis during development and disease pathogenesis re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8fe5c24707fa965f10cc299f58a5d446
https://doi.org/10.21203/rs.3.rs-1930733/v1
https://doi.org/10.21203/rs.3.rs-1930733/v1
Autor:
Céline Portal, Yvonne Lin, Varuni Rastogi, Cornelia Peterson, James Foster, Amber Wilkerson, Igor Butovich, Carlo Iomini
PurposePrimary cilia regulate the development of various ectoderm-derived tissues, including the corneal epithelium, skin, hair follicle and sebaceous glands. We aimed to investigate their role in meibomian gland (MG) development.MethodsPrimary ciliu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::667306cfe7f590aeff05cdbf8fece452
https://doi.org/10.1101/2022.05.16.492188
https://doi.org/10.1101/2022.05.16.492188
Publikováno v:
Histochemistry and Cell Biology
Histochemistry and Cell Biology, Springer Verlag, 2019, Histochemistry and cell biology, 152, pp.167-174. ⟨10.1007/s00418-019-01785-5⟩
Histochemistry and Cell Biology, 2019, Histochemistry and cell biology, 152, pp.167-174. ⟨10.1007/s00418-019-01785-5⟩
Histochemistry and Cell Biology, Springer Verlag, 2019, 152, pp.167-174
Histochemistry and Cell Biology, Springer Verlag, 2019, Histochemistry and cell biology, 152, pp.167-174. ⟨10.1007/s00418-019-01785-5⟩
Histochemistry and Cell Biology, 2019, Histochemistry and cell biology, 152, pp.167-174. ⟨10.1007/s00418-019-01785-5⟩
Histochemistry and Cell Biology, Springer Verlag, 2019, 152, pp.167-174
International audience; The nose is a complex organ that filters and warms breathing airflow. The nasal epithelium is the first barrier between the host and the external environment and is covered by a mucus gel that is poorly documented. Mucins are
Publikováno v:
Investigative Opthalmology & Visual Science. 63:3
The transcription factor c-Myc (Myc) plays central regulatory roles in both self-renewal and differentiation of progenitors of multiple cell lineages. Here, we address its function in corneal epithelium (CE) maintenance and repair.Myc ablation in the