Multidimensional phenotyping predicts lifespan and quantifies health in Caenorhabditis elegans.

Autor: Céline N Martineau, André E X Brown, Patrick Laurent

Publikováno v: PLoS Computational Biology, Vol 16, Iss 7, p e1008002 (2020)

Ageing affects a wide range of phenotypes at all scales, but an objective measure of ageing remains challenging, even in simple model organisms. To measure the ageing process, we characterized the sequence of alterations of multiple phenotypes at org

Externí odkaz: https://doaj.org/article/eea0ba3374a643178d22dd8a0638107b

Innate immunity in C. elegans

Autor: Nathalie Pujol, Natalia V. Kirienko, Céline N Martineau

Publikováno v: Nematode Models of Development and Disease
Nematode Models of Development and Disease, 144, Elsevier, pp.309-351, 2021, Current Topics in Developmental Biology, ⟨10.1016/bs.ctdb.2020.12.007⟩
Current Topics in Developmental Biology ISBN: 9780128161777
Curr Top Dev Biol

In its natural habitat, C. elegans encounters a wide variety of microbes, including food, commensals and pathogens. To be able to survive long enough to reproduce, C. elegans has developed a complex array of responses to pathogens. These activities a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7066fc7c0df12df96eb54181dd0d52d1
https://hal.science/hal-03373535/file/CH0010_Pujol.pdf

Molecular and functional characterization of the only known hemiascomycete ortholog of the carboxyl terminus of Hsc70-interacting protein CHIP in the yeast Yarrowia lipolytica

Autor: Ronald Melki, Céline N. Martineau, Jean-Marie Beckerich, Marie-Thérèse Le Dall, Mehdi Kabani

Publikováno v: Cell Stress and Chaperones
Cell Stress and Chaperones, Springer Verlag, 2012, 17 (2), pp.229-241. ⟨10.1007/s12192-011-0302-6⟩

The carboxyl terminus of Hsc70-interacting protein (CHIP) is an Hsp70 co-chaperone and a U-box ubiquitin ligase that plays a crucial role in protein quality control in higher eukaryotes. The yeast Yarrowia lipolytica is the only known hemiascomycete

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0f67c07e286490aea405fe785d10736
https://hal.archives-ouvertes.fr/hal-01004276

Multiple Hsp70 isoforms in the eukaryotic cytosol : mere redundancy or functional specificity ?

Autor: Céline N. Martineau, Mehdi Kabani

Publikováno v: Current Genomics
Current Genomics, Bentham Science Publishers, 2008, 9 (5), pp.338-348. ⟨10.2174/138920208785133280⟩

International audience; Hsp70 molecular chaperones play a variety of functions in every organism, cell type and organelle, and their activities have been implicated in a number of human pathologies, ranging from cancer to neurodegenerative diseases.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::737f2b5469eab1480d48d1ac37453e8b
https://hal.archives-ouvertes.fr/hal-01183766