The demoiselle of X-inactivation: 50 years old and as trendy and mesmerising as ever.

Autor: Céline Morey, Philip Avner

Publikováno v: PLoS Genetics, Vol 7, Iss 7, p e1002212 (2011)

In humans, sexual dimorphism is associated with the presence of two X chromosomes in the female, whereas males possess only one X and a small and largely degenerate Y chromosome. How do men cope with having only a single X chromosome given that virtu

Externí odkaz: https://doaj.org/article/9646eff3a0114dda842721d1b23d91f5

The Ftx Noncoding Locus Controls X Chromosome Inactivation Independently of Its RNA Products

Autor: Antonio Romito, Christophe Huret, Edith Heard, Rafael Galupa, Giulia Furlan, Joke Gerarda van Bemmel, Céline Morey, Claire Rougeulle, Nancy Gutierrez Hernandez

Publikováno v: Molecular Cell
Molecular Cell, Elsevier, 2018, 70 (3), pp.462-472.e8. ⟨10.1016/j.molcel.2018.03.024⟩
Molecular Cell, 70(3), 462-+. Cell Press

Summary Accumulation of the Xist long noncoding RNA (lncRNA) on one X chromosome is the trigger for X chromosome inactivation (XCI) in female mammals. Xist expression, which needs to be tightly controlled, involves a cis -acting region, the X-inactiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa456019460da265a050dbf2259e0000
https://hal-cnrs.archives-ouvertes.fr/hal-03030391

Genetics and epigenetics of the X chromosome

Autor: Philip Avner, Céline Morey

Publikováno v: Annals of the New York Academy of Sciences. 1214:E18-E33

A consequence of Mendelian inheritance of X-linked traits is that women are more than equal to men in the face of X-linked diseases, protected as they are by the presence of two X chromosomes in their genome. This potentially beneficial inequality is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::048970b550e56da5daa428c6b1113600
https://doi.org/10.1111/j.1749-6632.2010.05943.x

Antagonist Xist and Tsix co-transcription during mouse oogenesis and maternal Xist expression during pre-implantation development calls into question the nature of the maternal imprint on the X chromosome

Autor: Nathalie Beaujean, Philip Avner, Céline Morey, Jane Lynda Deuve, Amélie Bonnet-Garnier

Publikováno v: Epigenetics
Epigenetics, Taylor & Francis, 2015, 10 (10), pp.931-942. ⟨10.1080/15592294.2015.1081327⟩
Epigenetics, 2015, 10 (10), pp.931-942. ⟨10.1080/15592294.2015.1081327⟩
Epigenetics 10 (10), 931-942. (2015)

International audience; During the first divisions of the female mouse embryo, the paternal X-chromosome is coated by Xist non-coding RNA and gradually silenced. This imprinted X-inactivation principally results from the apposition, during oocyte gro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb502970ac92746f8f3f27291d2f168e
https://hal.archives-ouvertes.fr/hal-02365201/document

Spontaneous Reactivation of Clusters of X-Linked Genes Is Associated with the Plasticity of X-Inactivation in Mouse Trophoblast Stem Cells

Autor: Céline Morey, Agnès Dubois, Jane Lynda Deuve, Pierre-Henri Commere, Sylvain Pichard, Danielle Arnaud, Sarra Merzouk, Pablo Navarro, Anne Louise, Philip Avner

Publikováno v: STEM CELLS
STEM CELLS, AlphaMed Press, 2014, 32 (2), pp.377-390. ⟨10.1002/stem.1557⟩
STEM CELLS, 2014, 32 (2), pp.377-390. ⟨10.1002/stem.1557⟩

Random epigenetic silencing of the X-chromosome in somatic tissues of female mammals equalizes the dosage of X-linked genes between the sexes. Unlike this form of X-inactivation that is essentially irreversible, the imprinted inactivation of the pate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::631676bed639a144778f1a2769fe99f9
https://hal-pasteur.archives-ouvertes.fr/pasteur-02025041