Enhanced bioproduction of anticancer precursor vindoline by yeast cell factories

Autor: Natalja Kulagina, Grégory Guirimand, Céline Melin, Pamela Lemos‐Cruz, Ines Carqueijeiro, Johan‐Owen De Craene, Audrey Oudin, Vladimir Heredia, Konstantinos Koudounas, Marianne Unlubayir, Arnaud Lanoue, Nadine Imbault, Benoit St‐Pierre, Nicolas Papon, Marc Clastre, Nathalie Giglioli‐Guivarc’h, Jillian Marc, Sébastien Besseau, Vincent Courdavault

Publikováno v: Microbial Biotechnology, Vol 14, Iss 6, Pp 2693-2699 (2021)

Summary The pharmaceutical industry faces a growing demand and recurrent shortages in many anticancer plant drugs given their extensive use in human chemotherapy. Efficient alternative strategies of supply of these natural products such as bioproduct

Externí odkaz: https://doaj.org/article/60e784bff10b43a9a3cb622a92581120

Setting-up a fast and reliable cytokinin biosensor based on a plant histidine kinase receptor expressed in Saccharomyces cerevisiae

Autor: Anna Kisiala, Laura Perrot, Joël Crèche, Nicolas Papon, Arnaud Lanoue, Olivier Pichon, Dimitri Daudu, Céline Melin, Carolina Werner Ribeiro, Sabine Carpin, Matthieu Gaucher, Marie-Noëlle Brisset, Audrey Oudin, Philippe Lanotte, Thomas Dugé de Bernonville, Marc Clastre, Vincent Courdavault, Catherine Schouler, Sébastien Besseau, Martine Courtois, Alexandre Degrave, R. J. Neil Emery, Nathalie Giglioli-Guivarc'h, Gaëlle Glévarec

Publikováno v: Journal of Biotechnology
Journal of Biotechnology, 2019, 289, pp.103-111. ⟨10.1016/j.jbiotec.2018.11.013⟩
Journal of Biotechnology, Elsevier, 2019, 289, pp.103-111. ⟨10.1016/j.jbiotec.2018.11.013⟩

International audience; Cytokinins (CK) have been extensively studied for their roles in plant development. Recently, they also appeared to ensure crucial functions in the pathogenicity of some bacterial and fungal plant pathogens. Thus, identifying

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a68d6bd233db083200da7a9725a838e7
https://hal.archives-ouvertes.fr/hal-02102155

Mechanical stress rapidly induces E-resveratrol and E-piceatannol biosynthesis in grape canes stored as a freshly-pruned byproduct

Autor: Céline Melin, Vincent Courdavault, Marc Clastre, Audrey Oudin, Nathalie Giglioli-Guivarc’h, Nicolas Papon, Kévin Billet, Arnaud Lanoue, Sébastien Besseau, Benjamin Houillé

Publikováno v: Food Chemistry
Food Chemistry, Elsevier, 2018, 240, pp.1022-1027. ⟨10.1016/j.foodchem.2017.07.105⟩

Grape canes represent a promising source of bioactive phytochemicals. However the stabilization of the raw material after pruning remains challenging. We recently reported the induction of stilbenoid metabolism after winter pruning including a strong

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03e16d8549bedd3cbc73cc2cdb736a52
https://hal.univ-angers.fr/hal-02407075

A new series of vectors for constitutive, inducible or repressible gene expression in Candida guilliermondii

Autor: Andrew J. Simkin, Emilien Foureau, Vincent Courdavault, Céline Melin, Erika J. Obando Montoya, Arnaud Lanoue, Marc Clastre, Joël Crèche, Gaëlle Glévarec, Lucía Atehortúa, Audrey Oudin, Tatiana A. Defosse, Nicolas Papon, Nathalie Giglioli-Guivarc’h

Publikováno v: Journal of Biotechnology. 180:37-42

The biotechnological potential of C. guilliermondii is now well established. This yeast species currently benefits from the availability of a convenient molecular toolbox including recipient strains, selectable markers and optimized transformation pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3e690aaa0d305c0753044ac14e63a7a
https://doi.org/10.1016/j.jbiotec.2014.03.034

Optimized genetic transformation ofZanthoxylum zanthoxyloidesbyAgrobacterium rhizogenesand the production of chelerythrine and skimmiamine in hairy root cultures

Autor: Kodjo Djidjolé Etsè, Céline Melin, Vincent Courdavault, Audrey Oudin, Arnaud Lanoue, Joël Crèche, Atsou Aïdam, Nathalie Blanc

Publikováno v: Engineering in Life Sciences. 14:95-99

Zanthoxylum zanthoxyloides is an endangered African tree producing numerous bioactive substances including antileukemic and antisickling agents. Here, the potential of Z. zanthoxyloides hairy root cultures was tested for the production of bioactive s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b421a26ccf991901de72e64bd70d79b6
https://doi.org/10.1002/elsc.201200216