Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Céline Marban"'
Autor:
Michel Siegel, Anna-Lena Bolender, Axel Ducret, Johannes Fraidling, Katharina Hartman, Cary M. Looney, Olivier Rohr, Timothy P. Hickling, Hubert Kettenberger, Martin Lechmann, Céline Marban-Doran, Thomas E. Kraft
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionImmunogenicity, the unwanted immune response triggered by therapeutic antibodies, poses significant challenges in biotherapeutic development. This response can lead to the production of anti-drug antibodies, potentially compromising the e
Externí odkaz:
https://doaj.org/article/c01676e863fb443ca2e5f23f30eb48a1
Autor:
Michel Siegel, Aman Padamsey, Anna-Lena Bolender, Patrick Hargreaves, Johannes Fraidling, Axel Ducret, Katharina Hartman, Cary M. Looney, Cristina Bertinetti-Lapatki, Olivier Rohr, Timothy P. Hickling, Thomas E. Kraft, Céline Marban-Doran
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionImmunogenicity refers to the ability of a substance, such as a therapeutic drug, to elicit an immune response. While beneficial in vaccine development, undesirable immunogenicity can compromise the safety and efficacy of therapeutic prote
Externí odkaz:
https://doaj.org/article/7d40f92e19414c188759d42872e0dd4b
Autor:
Katharina Hartman, Guido Steiner, Michel Siegel, Cary M. Looney, Timothy P. Hickling, Katharine Bray-French, Sebastian Springer, Céline Marban-Doran, Axel Ducret
Publikováno v:
Biology, Vol 12, Iss 9, p 1265 (2023)
A critical step in the immunogenicity cascade is attributed to human leukocyte antigen (HLA) II presentation triggering T cell immune responses. The liquid chromatography–tandem mass spectrometry (LC-MS/MS)-based major histocompatibility complex (M
Externí odkaz:
https://doaj.org/article/60580742da114302a53620a33953db56
Autor:
Michel Siegel, Guido Steiner, Linnea C. Franssen, Francesca Carratu, James Herron, Katharina Hartman, Cary M. Looney, Axel Ducret, Katharine Bray-French, Olivier Rohr, Timothy P. Hickling, Noel Smith, Céline Marban-Doran
Publikováno v:
Pharmaceutics, Vol 14, Iss 12, p 2672 (2022)
Immunogenicity, defined as the ability to provoke an immune response, can be either wanted (i.e., vaccines) or unwanted. The latter refers to an immune response to protein or peptide therapeutics, characterized by the production of anti-drug antibodi
Externí odkaz:
https://doaj.org/article/9163ac23f8bd4fae95f0bd210a951c5c
Autor:
Pauline Dartevelle, Claire Ehlinger, Abdurraouf Zaet, Christian Boehler, Morgane Rabineau, Benoit Westermann, Jean-Marc Strub, Sarah Cianferani, Youssef Haïkel, Marie-Hélène Metz-Boutigue, Céline Marban
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Abstract The excessive use of antifungal agents, compounded by the shortage of new drugs being introduced into the market, is causing the accumulation of multi-resistance phenotypes in many fungal strains. Consequently, new alternative molecules to c
Externí odkaz:
https://doaj.org/article/6542be9b5ef34063b0fd3b1f1dd72f6f
Autor:
Rizwan Aslam, Céline Marban, Christian Corazzol, François Jehl, François Delalande, Alain Van Dorsselaer, Gilles Prévost, Youssef Haïkel, Corinne Taddei, Francis Schneider, Marie-Hélène Metz-Boutigue
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e68993 (2013)
Innate immunity involving antimicrobial peptides represents an integrated and highly effective system of molecular and cellular mechanisms that protects host against infections. One of the most frequent hospital-acquired pathogens, Staphylococcus aur
Externí odkaz:
https://doaj.org/article/3161b11be70544edba4ed664c0060106
Autor:
Céline Marban, Trent Su, Roberto Ferrari, Bing Li, Dimitrios Vatakis, Matteo Pellegrini, Jerome A Zack, Olivier Rohr, Siavash K Kurdistani
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e26894 (2011)
The HIV-1 Trans-Activator of Transcription (Tat) protein binds to multiple host cellular factors and greatly enhances the level of transcription of the HIV genome. While Tat's control of viral transcription is well-studied, much less is known about t
Externí odkaz:
https://doaj.org/article/efa45ae2e9ec4733905ff85190b6f837
Autor:
Neil Campbell, Céline Marban-Doran, Axel Ducret, Guido Steiner, Kay-Gunnar Stubenrauch, Katharine Bray-French, Katharina Hartman, Thomas Singer, Juliana Bessa, Corinne Solier, Meret Martin-Facklam
Publikováno v:
Journal of pharmaceutical sciences. 110(7)
Biotherapeutics have revolutionized our ability to treat life-threatening diseases. Despite clinical success, the use of biotherapeutics has sometimes been limited by the immune response mounted against them in the form of anti-drug antibodies (ADAs)
Autor:
Jessica Langer, Guido Steiner, Corinne Solier, Katharine Bray-French, Tatiana Pimenova, Anja Langenkamp, Axel Ducret, Gonzalo Duran-Pacheco, Thomas Singer, Céline Marban-Doran, Denise Sauter
Publikováno v:
Journal of proteome research. 19(9)
Major histocompatibility complex-II (MHC-II)-Associated Peptide Proteomics (MAPPs) is a mass spectrometry-based approach to identify and relatively quantitate naturally processed and presented MHC-II-associated peptides that can potentially activate
Autor:
Olivier Rohr, Francesco Scavello, Marie-Hélène Metz-Boutigue, Gharib Ajob, Max Guillot, Céline Marban, Anne Launoy, Sophie Hellé, Francis Schneider, Quentin Maestraggi
Publikováno v:
Shock
Shock, Lippincott, Williams & Wilkins, 2018, 49 (5), pp.522-528. ⟨10.1097/SHK.0000000000001000⟩
Shock, Lippincott, Williams & Wilkins, 2018, 49 (5), pp.522-528. ⟨10.1097/SHK.0000000000001000⟩
In previously healthy persons suffering from acute illnesses, nosocomial infections (NIs) are frequent. Their prevalence suggests the existence of as yet unknown conditions that may promote care-related infection. This study assessed whether the meas