Zobrazeno 1 - 10 of 24 pro vyhledávání: '"Céline Mamie"'
1
Akademický článek
pH-Sensing G Protein-Coupled Receptor OGR1 (GPR68) Expression and Activation Increases in Intestinal Inflammation and Fibrosis
Autor: Cheryl de Vallière, Jesus Cosin-Roger, Katharina Baebler, Anja Schoepflin, Céline Mamie, Michelle Mollet, Cordelia Schuler, Susan Bengs, Silvia Lang, Michael Scharl, Klaus Seuwen, Pedro A. Ruiz, Martin Hausmann, Gerhard Rogler
Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 3, p 1419 (2022)
Local extracellular acidification occurs at sites of inflammation. Proton-sensing ovarian cancer G-protein-coupled receptor 1 (OGR1, also known as GPR68) responds to decreases in extracellular pH. Our previous studies show a role for OGR1 in the path
Externí odkaz: https://doaj.org/article/58ec6e651d7547c7aa3917826ba76e7a
Zobrazit plný text záznamu
2
Akademický článek
Succinate Activates EMT in Intestinal Epithelial Cells through SUCNR1: A Novel Protagonist in Fistula Development
Autor: Dolores Ortiz-Masiá, Laura Gisbert-Ferrándiz, Cristina Bauset, Sandra Coll, Céline Mamie, Michael Scharl, Juan V. Esplugues, Rafael Alós, Francisco Navarro, Jesús Cosín-Roger, María D. Barrachina, Sara Calatayud
Publikováno v: Cells, Vol 9, Iss 5, p 1104 (2020)
The pathogenesis of Crohn’s disease-associated fibrostenosis and fistulas imply the epithelial-to-mesenchymal transition (EMT) process. As succinate and its receptor (SUCNR1) are involved in intestinal inflammation and fibrosis, we investigated the
Externí odkaz: https://doaj.org/article/593bc16324b04ccfb711f32abf6ef593
Zobrazit plný text záznamu
3
Deletion of Smad7 Ameliorates Intestinal Inflammation and Contributes to Fibrosis
Autor: Cordelia Schuler, Federica Foti, Leonie Perren, Céline Mamie, Bruce Weder, Michelle Stokmaier, Cheryl de Vallière, Rainer Heuchel, Pedro A Ruiz, Gerhard Rogler, Martin Hausmann
Publikováno v: Inflammatory Bowel Diseases. 29:647-660
Background Patients suffering from inflammatory bowel diseases (IBDs) express increased mucosal levels of transforming growth factor (TGF)-β compared with non-IBD controls. SMAD7 negatively regulates TGF-β signaling. An earlier study aiming to targ
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a84ac12646119f144f4c9cebcaa91483
https://doi.org/10.1093/ibd/izac221
Zobrazit plný text záznamu
4
New Therapeutic Approach for Intestinal Fibrosis Through Inhibition of pH-Sensing Receptor GPR4
Autor: Carsten A. Wagner, Sebastian Mueller, Eleonora Patsenker, Katharina Baebler, Fabian Schefer, Cordelia Schuler, Gerard Dijkstra, Martin Hausmann, Senta Hutter, Céline Mamie, Isabelle Frey-Wagner, Wouter T. van Haaften, Felix Stickel, Gerhard Rogler, Pedro A. Ruiz, Bruce Weder, Klaus Seuwen, Pedro Henrique Imenez Silva, Yu Wang, Cheryl de Valliere
Publikováno v: Inflammatory Bowel Diseases, 28(1), 109-125. LIPPINCOTT WILLIAMS & WILKINS
BackgroundPatients suffering from inflammatory bowel diseases (IBDs) express increased mucosal levels of pH-sensing receptors compared with non-IBD controls. Acidification leads to angiogenesis and extracellular matrix remodeling. We aimed to determi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8644ad0424d49aa34673eb32a4857683
https://doi.org/10.1093/ibd/izab140
Zobrazit plný text záznamu
5
MMP9 expression in intestinal fistula from patients with fistulizing CD and from human xenograft mouse model
Autor: Andreas Rickenbacher, Nahum Y. Shpigel, Yolanda Chvatchko, Céline Mamie, Michael Scharl, Daniela Cabalzar-Wondberg, Gerhard Rogler, Matthias Turina, Silvia Lang, Ramona S Bruckner
Publikováno v: Tissue Barriers
Fistula treatment represents a major unmet medical need in the therapy of Crohn’s disease (CD). Current medical therapies, such as anti-TNF antibody treatments, are often insufficient and do not achieve permanent fistula closure. Previously publish
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e717395b94662f588affb9d72dc341a
https://europepmc.org/articles/PMC9067458/
Zobrazit plný text záznamu
6
The Oxysterol Synthesising Enzyme CH25H Contributes to the Development of Intestinal Fibrosis
Autor: Benjamin Misselwitz, Annika Wyss, W. T. van Haaften, Gerhard Rogler, Céline Mamie, Andreas W. Sailer, Vinko Tosevski, Martin Hausmann, P H Imenez Silva, Michael Scharl, Bruce Weder, Gerard Dijkstra, M.N. Gonzalez Alvarado, Tina Raselli, Carsten A. Wagner, Marianne R. Spalinger, Sebastian Leibl
Publikováno v: Journal of Crohn's & Colitis
Journal of Crohn's and Colitis, 13(9), 1186-1200. Oxford University Press
Intestinal fibrosis and stenosis are common complications of Crohn’s disease [CD], frequently requiring surgery. Anti-inflammatory strategies can only partially prevent fibrosis; hence, anti-fibrotic therapies remain an unmet clinical need. Oxyster
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afa3ed79cb8d59635b939aff796c3342
https://doi.org/10.1093/ecco-jcc/jjz039
Zobrazit plný text záznamu
8
WNT2b activates epithelial-mesenchymal transition through FZD4: relevance in penetrating Crohns disease
Autor: Jesus Cosin-Roger, Sara Calatayud, Céline Mamie, Dolores Ortiz-Masiá, P Salvador, J. Manyé, L Gisbert-Ferrándiz, Francisco Navarro-Vicente, Dulce C Macias-Ceja, Maria D. Barrachina, Juan V. Esplugues, Michael Scharl, Rafael Alós
Publikováno v: Journal of Crohn's & colitis
r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
instname
JOURNAL OF CROHNS & COLITIS
r-IGTP: Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
Universidad de Alicante (UA)
r-FISABIO. Repositorio Institucional de Producción Científica
r-FISABIO: Repositorio Institucional de Producción Científica
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
Background and Aims Epithelial-mesenchymal transition [EMT] has been related to fibrosis and fistula formation, common complications associated with Crohn´s disease [CD]. The WNT signalling pathway mediates EMT, and specific WNT/FZD interactions hav
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a94c73286d7bb4cc08e86d7d292f02d
https://www.fundanet.incliva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=3965
Zobrazit plný text záznamu
9
Severity of local inflammation does not impact development of fibrosis in mouse models of intestinal fibrosis
Autor: Anouk Hünerwadel, Céline Mamie, Stefania Fagagnini, S. U. Jaeger, Bruce Weder, Christian Lutz, Martin Hausmann, Gerhard Rogler, Pedro A. Ruiz
Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
Scientific Reports
Intestinal fibrosis is thought to be a consequence of excessive tissue repair, and constitutes a common problem in patients with Crohn’s disease (CD). While fibrosis seems to require inflammation as a prerequisite it is unclear whether the severity
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87702d3d60e21dfbcf58e4cf04362b3b
http://link.springer.com/article/10.1038/s41598-018-33452-5
Zobrazit plný text záznamu
10
Tofacitinib for the Treatment of Pyoderma Gangrenosum
Autor: Alexander A. Navarini, Céline Mamie, Michael Scharl, Neel Herfarth, Bharati Kochar, Hans H Herfarth
Publikováno v: Clin Gastroenterol Hepatol
Pyoderma gangrenosum (PG) is a difficult-to-treat inflammatory skin condition that affects inflammatory bowel disease (IBD) patients. There is no standardized approach for PG treatment.1 We report the results of 3 patients with Crohn's disease (CD) a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b89a7b06266ecb5b281f08cd26131f9
https://www.zora.uzh.ch/id/eprint/158478/
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje