Data from Dependence on Phosphoinositide 3-Kinase and RAS-RAF Pathways Drive the Activity of RAF265, a Novel RAF/VEGFR2 Inhibitor, and RAD001 (Everolimus) in Combination

Autor: Eric Deutsch, Jean-Charles Soria, Marie Wislez, Jean Bourhis, Julien Calderaro, Céline Leteur, Yohann Loriot, Pierre Mordant

Activation of phosphatidylinositol-3-kinase (PI3K)-AKT and Kirsten rat sarcoma viral oncogene homologue (KRAS) can induce cellular immortalization, proliferation, and resistance to anticancer therapeutics such as epidermal growth factor receptor inhi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::447b5be68245ff8446df65b0794200e8
https://doi.org/10.1158/1535-7163.c.6531714

MBNL‐dependent impaired development within the neuromuscular system in myotonic dystrophy type 1

Autor: Julie Tahraoui‐Bories, Antoine Mérien, Anchel González‐Barriga, Jeanne Lainé, Céline Leteur, Hélène Polvèche, Alexandre Carteron, Juliette Duchesne De Lamotte, Camille Nicoleau, Jérome Polentes, Margot Jarrige, Mário Gomes‐Pereira, Erwann Ventre, Pauline Poydenot, Denis Furling, Laurent Schaeffer, Claire Legay, Cécile Martinat

Publikováno v: Neuropathology and Applied Neurobiology
Neuropathology and Applied Neurobiology, 2023, 49 (1), ⟨10.1111/nan.12876⟩

Myotonic dystrophy type I (DM1) is one the most frequent muscular dystrophies in adults. Although DM1 has long been considered mainly a muscle disorder, growing evidence suggests the involvement of peripheral nerves in the pathogenicity of DM1 raisin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::423504cc1870fcfb2f82d1ef7a288f78
https://hal.science/hal-03992575

NOX2-dependent ATM kinase activation dictates pro-inflammatory macrophage phenotype and improves effectiveness to radiation therapy

Autor: Laurent Voisin, Céline Leteur, Fabien Milliat, Eric Deutsch, Qiuji Wu, Eric Solary, Zeinaf Muradova, Haithem Dakhli, Audrey Paoletti, Awatef Allouch, Jean-Luc Perfettini, Filippo Rosselli, Frédéric Law, Mélanie Gauthier, David M. Ojcius, Maxime Thoreau, Elodie Mintet, Nazanine Modjtahedi, Olivier Caron, Isabelle Martins, Céline Mirjolet

Publikováno v: Cell Death and Differentiation
Cell Death and Differentiation, Nature Publishing Group, 2017, 24 (9), pp.1632-1644. ⟨10.1038/cdd.2017.91⟩
Cell death and differentiation, vol 24, iss 9

International audience; Although tumor-associated macrophages have been extensively studied in the control of response to radiotherapy, the molecular mechanisms involved in the ionizing radiation-mediated activation of macrophages remain elusive. Her

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6759127a749327af11845b7d793bf58d
https://hal.archives-ouvertes.fr/hal-02391926

Ciblage pharmacologique de Mdm2 : bases biologiques et perspectives de radiosensibilisation

Autor: Charles Ferté, Céline Leteur, Benoit Lahon, Jean Bourhis, Caroline Rivera, Eric Deutsch, M. Deberne, Cyrus Chargari

Publikováno v: Cancer/Radiothérapie. 15:316-322

Resume La proteine p53 joue un role central dans la reponse aux rayonnements ionisants. Mdm2, son principal regulateur negatif, constitue donc une cible seduisante a des fins de radiosensibilisation. Cette revue de la litterature fait l’etat des li

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a13bcc638b7e6eaa84fce2220ef809c9
https://doi.org/10.1016/j.canrad.2011.02.003

Preclinical assessment of JNJ-26854165 (Serdemetan), a novel tryptamine compound with radiosensitizing activity in vitro and in tumor xenografts

Autor: Céline Leteur, Eric Angevin, Janine Arts, Bruno Schoentjes, Eric Deutsch, Tarig Bashir, Jean Bourhis, Cyrus Chargari, Michel Janicot

Publikováno v: Cancer letters. 312(2)

Serdemetan (JNJ-26854165) is a novel tryptamine compound with antiproliferative activity in various p53 wild-type (WT) tumor cell lines. We investigated its potential as radiosensitizer using four human cancer cell lines: H460, A549, p53-WT-HCT116, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::125df126ce5eceaa55bd20a928c7f062
https://pubmed.ncbi.nlm.nih.gov/21937165