Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Céline Jacquemont"'
Proteasome inhibitors sensitize tumor cells to DNA-damaging agents, including ionizing radiation (IR), and DNA cross-linking agents (melphalan and cisplatin) through unknown mechanisms. The Fanconi anemia pathway is a DNA damage–activated signaling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac9316739572ed18b783021ed51737bc
https://doi.org/10.1158/0008-5472.c.6495639
https://doi.org/10.1158/0008-5472.c.6495639
Autor:
Toshiyasu Taniguchi, Emily Villegas, Jake Higgins, Kaitlyn Wurz, Simon P. Langdon, Fergus J. Couch, Kurapaty Venkatapoorna Chandramohan, Céline Jacquemont, Elizabeth M. Swisher, Wataru Sakai
Supplementary Figures S1-S5 from Functional Restoration of BRCA2 Protein by Secondary BRCA2 Mutations in BRCA2-Mutated Ovarian Carcinoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::647ab0fb9190e354ef3784ae983f9aa4
https://doi.org/10.1158/0008-5472.22378347.v1
https://doi.org/10.1158/0008-5472.22378347.v1
Supplementary Figures 1-3 from Proteasome Function Is Required for DNA Damage Response and Fanconi Anemia Pathway Activation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18e88d2b094d22ba09df4ebe74c078bf
https://doi.org/10.1158/0008-5472.22367652.v1
https://doi.org/10.1158/0008-5472.22367652.v1
Autor:
Yong Chi, Masaoki Kawasumi, Nyka Tucker, Toshiyasu Taniguchi, Yemin Wang, Jen-Wei Huang, Kaoru Sugasawa, Philip R. Gafken, Bruce E. Clurman, Paul Nghiem, Masafumi Saijo, Kiranjit K. Dhillon, Céline Jacquemont, Philamer C. Calses
Publikováno v:
Cell Reports, Vol 19, Iss 1, Pp 162-174 (2017)
Ultraviolet (UV) radiation is a carcinogen that generates DNA lesions. Here, we demonstrate an unexpected role for DGCR8, an RNA binding protein that canonically functions with Drosha to mediate microRNA processing, in the repair of UV-induced DNA le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8ab02d8ae6bd5aeb67b1726204f31a9
https://doi.org/10.1016/j.celrep.2017.03.021
https://doi.org/10.1016/j.celrep.2017.03.021
Publikováno v:
Cell Cycle
Proteins essential for homologous recombination play a pivotal role in the repair of DNA double strand breaks, DNA inter-strand crosslinks and replication fork stability. Defects in homologous recombination also play a critical role in the developmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fc14a2387c9d1f969a54086a86d2573
https://doi.org/10.1080/15384101.2016.1259038
https://doi.org/10.1080/15384101.2016.1259038
Autor:
Thomas F Gajewski, John A Thompson, Sanjay Goel, Brendan D Curti, Elisabeth I Heath, Olivier Rixe, David C Smith, Celine Jacquemont, Tycel Phillips, Martin Gutierrez, Sahar Ansari, Andrew L Coveler, Svetomir N Markovic, Timothy M Kuzel, Amitkumar N Mehta, David L Bajor, Hun Ju Lee, Ajay K Gopal, Paolo Caimi, Ariel Topletz-Erickson, Peigen Zhou, Michael W Schmitt, Juneko E Grilley-Olson
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 6 (2023)
Background SEA-CD40 is an investigational, non-fucosylated, humanized monoclonal IgG1 antibody that activates CD40, an immune-activating tumor necrosis factor receptor superfamily member. SEA-CD40 exhibits enhanced binding to activating FcγRIIIa, po
Externí odkaz:
https://doaj.org/article/997d45d0420040f2a6abbe4400763c7d
Autor:
Daniel J. Farrugia, Nicole Urban, Wataru Sakai, Fergus J. Couch, Céline Jacquemont, Mukesh K. Agarwal, Toshiyasu Taniguchi, Emily Villegas, Jake Higgins, Beth Y. Karlan, Cynthia Friedman, Elizabeth M. Swisher
Publikováno v:
Nature. 451:1116-1120
Ovarian carcinomas with mutations in the tumour suppressor BRCA2 are particularly sensitive to platinum compounds. However, such carcinomas ultimately develop cisplatin resistance. The mechanism of that resistance is largely unknown. Here we show tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b6e2f4edbd15f43b73d71868bf952ca
https://doi.org/10.1038/nature06633
https://doi.org/10.1038/nature06633
Autor:
Céline Jacquemont, Toshiyasu Taniguchi
Publikováno v:
Cancer Research. 67:7395-7405
Proteasome inhibitors sensitize tumor cells to DNA-damaging agents, including ionizing radiation (IR), and DNA cross-linking agents (melphalan and cisplatin) through unknown mechanisms. The Fanconi anemia pathway is a DNA damage–activated signaling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6d883c708a8b2c734938db87b043726
https://doi.org/10.1158/0008-5472.can-07-1015
https://doi.org/10.1158/0008-5472.can-07-1015
Autor:
Eric A. Hendrickson, Ronald S. Cheung, Jen-Wei Huang, Maria Castella, Jung Eun Yeo, Elizabeth L. Thompson, Céline Jacquemont, Toshiyasu Taniguchi, Alexandra Sobeck
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 11, Iss 10, p e1005563 (2015)
PLoS Genetics, Vol 11, Iss 10, p e1005563 (2015)
The Fanconi anemia (FA)-BRCA pathway mediates repair of DNA interstrand crosslinks. The FA core complex, a multi-subunit ubiquitin ligase, participates in the detection of DNA lesions and monoubiquitinates two downstream FA proteins, FANCD2 and FANCI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c29d97ec9168092f9dd0065ac8711bb6
https://pubmed.ncbi.nlm.nih.gov/26430909
https://pubmed.ncbi.nlm.nih.gov/26430909
Autor:
Dominique Stoppa-Lyonnet, Dora Papadopoulo, Julianne Smith, Céline Jacquemont, Isabelle De Oliveira, Jean Feunteun, Céline Baldeyron, Sophie Gad, Emilie Jacquemin
Publikováno v:
Oncogene. 21:1401-1410
Heterozygosity for mutations in the BRCA1 gene in humans confers high risk for developing breast cancer, but a biochemical basis for this phenotype has not yet been determined. Evidence has accumulated implicating BRCA1, in the maintenance of genomic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d64b8bc9b1fd914c7a6830946cba6a6
https://doi.org/10.1038/sj.onc.1205200
https://doi.org/10.1038/sj.onc.1205200