Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Céline Gheeraert"'
Autor:
Ninon Very, Clémence Boulet, Céline Gheeraert, Alexandre Berthier, Manuel Johanns, Mohamed Bou Saleh, Loïc Guille, Fabrice Bray, Jean-Marc Strub, Marie Bobowski-Gerard, Francesco P. Zummo, Emmanuelle Vallez, Olivier Molendi-Coste, Eloise Woitrain, Sarah Cianférani, David Montaigne, Line Carolle Ntandja-Wandji, Laurent Dubuquoy, Julie Dubois-Chevalier, Bart Staels, Philippe Lefebvre, Jérôme Eeckhoute
Publikováno v:
Cell Death and Disease, Vol 15, Iss 6, Pp 1-22 (2024)
Abstract Tissue injury causes activation of mesenchymal lineage cells into wound-repairing myofibroblasts (MFs), whose uncontrolled activity ultimately leads to fibrosis. Although this process is triggered by deep metabolic and transcriptional reprog
Externí odkaz:
https://doaj.org/article/7c469a228cd14e0cb8f4aa98dabc701e
Autor:
Frédérik Oger, Maeva Moreno, Mehdi Derhourhi, Bryan Thiroux, Lionel Berberian, Cyril Bourouh, Emmanuelle Durand, Souhila Amanzougarene, Alaa Badreddine, Etienne Blanc, Olivier Molendi-Coste, Laurent Pineau, Gianni Pasquetti, Laure Rolland, Charlène Carney, Florine Bornaque, Emilie Courty, Céline Gheeraert, Jérôme Eeckhoute, David Dombrowicz, Julie Kerr-Conte, François Pattou, Bart Staels, Philippe Froguel, Amélie Bonnefond, Jean-Sébastien Annicotte
Publikováno v:
iScience, Vol 26, Iss 7, Pp 107231- (2023)
Summary: Histone deacetylases enzymes (HDACs) are chromatin modifiers that regulate gene expression through deacetylation of lysine residues within specific histone and non-histone proteins. A cell-specific gene expression pattern defines the identit
Externí odkaz:
https://doaj.org/article/75620a5d73cf44908a7169d2d5030f87
Autor:
Marie Bobowski-Gerard, Clémence Boulet, Francesco P. Zummo, Julie Dubois-Chevalier, Céline Gheeraert, Mohamed Bou Saleh, Jean-Marc Strub, Amaury Farce, Maheul Ploton, Loïc Guille, Jimmy Vandel, Antonino Bongiovanni, Ninon Very, Eloïse Woitrain, Audrey Deprince, Fanny Lalloyer, Eric Bauge, Lise Ferri, Line-Carolle Ntandja-Wandji, Alexia K. Cotte, Corinne Grangette, Emmanuelle Vallez, Sarah Cianférani, Violeta Raverdy, Robert Caiazzo, Viviane Gnemmi, Emmanuelle Leteurtre, Benoit Pourcet, Réjane Paumelle, Kim Ravnskjaer, Guillaume Lassailly, Joel T. Haas, Philippe Mathurin, François Pattou, Laurent Dubuquoy, Bart Staels, Philippe Lefebvre, Jérôme Eeckhoute
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
Myofibroblasts contribute to the development of liver fibrosis. Here, the authors report that the transcription factor Basonuclin 2 (BNC2) integrates fibrogenic signals and drives myofibroblastic transcriptional activation in liver fibrosis.
Externí odkaz:
https://doaj.org/article/c0d2d56ec91641b79809fad780054395
Autor:
Daniel Margerie, Philippe Lefebvre, Violeta Raverdy, Uwe Schwahn, Hartmut Ruetten, Philip Larsen, Alain Duhamel, Julien Labreuche, Dorothée Thuillier, Bruno Derudas, Céline Gheeraert, Hélène Dehondt, Quentin Dhalluin, Jérémy Alexandre, Robert Caiazzo, Pamela Nesslany, Helene Verkindt, François Pattou, Bart Staels
Publikováno v:
BMC Medical Genomics, Vol 12, Iss 1, Pp 1-10 (2019)
Abstract Background Clinical data identified an association between the use of HMG-CoA reductase inhibitors (statins) and incident diabetes in patients with underlying diabetes risk factors such as obesity, hypertension and dyslipidemia. The molecula
Externí odkaz:
https://doaj.org/article/9dfc1476bb6445368598bcee1cad784b
Autor:
Vanessa Dubois, Céline Gheeraert, Wouter Vankrunkelsven, Julie Dubois‐Chevalier, Hélène Dehondt, Marie Bobowski‐Gerard, Manjula Vinod, Francesco Paolo Zummo, Fabian Güiza, Maheul Ploton, Emilie Dorchies, Laurent Pineau, Alexis Boulinguiez, Emmanuelle Vallez, Eloise Woitrain, Eric Baugé, Fanny Lalloyer, Christian Duhem, Nabil Rabhi, Ronald E van Kesteren, Cheng‐Ming Chiang, Steve Lancel, Hélène Duez, Jean‐Sébastien Annicotte, Réjane Paumelle, Ilse Vanhorebeek, Greet Van den Berghe, Bart Staels, Philippe Lefebvre, Jérôme Eeckhoute
Publikováno v:
Molecular Systems Biology, Vol 16, Iss 5, Pp n/a-n/a (2020)
Abstract Liver injury triggers adaptive remodeling of the hepatic transcriptome for repair/regeneration. We demonstrate that this involves particularly profound transcriptomic alterations where acute induction of genes involved in handling of endopla
Externí odkaz:
https://doaj.org/article/25e5ed41e1224b8fae474a62d14c30b5
Autor:
Fanny Lalloyer, Denis A. Mogilenko, Ann Verrijken, Joel T. Haas, Antonin Lamazière, Mostafa Kouach, Amandine Descat, Sandrine Caron, Emmanuelle Vallez, Bruno Derudas, Céline Gheeraert, Eric Baugé, Gaëtan Despres, Eveline Dirinck, Anne Tailleux, David Dombrowicz, Luc Van Gaal, Jerôme Eeckhoute, Philippe Lefebvre, Jean-François Goossens, Sven Francque, Bart Staels
Publikováno v:
Journal of Hepatology.
Autor:
Francesco Paolo Zummo, Alexandre Berthier, Céline Gheeraert, Manjula Vinod, Marie Bobowski-Gérard, Olivier Molendi-Coste, Laurent Pineau, Matthieu Jung, Loic Guille, Julie Chevalier-Dubois, David Dombrowicz, Bart Staels, Jérôme Eeckhoute, Philippe Lefebvre
Publikováno v:
Journal of Molecular Endocrinology
Journal of Molecular Endocrinology, 2023, ⟨10.1530/JME-23-0017⟩
Journal of Molecular Endocrinology, 2023, ⟨10.1530/JME-23-0017⟩
The functional versatility of the liver is paramount for organismal homeostasis. Adult liver functions are controlled by a tightly regulated transcription factor network including nuclear receptors (NRs), which orchestrate many aspects of hepatic phy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5a92ad2f25e1bf588b31b45fdba162c
https://www.hal.inserm.fr/inserm-04053458
https://www.hal.inserm.fr/inserm-04053458
Autor:
Frédérik Oger, Maeva Moreno, Mehdi Derhourhi, Bryan Thiroux, Lionel Berberian, Cyril Bourouh, Emmanuelle Durand, Souhila Amanzougarene, Alaa Badreddine, Etienne Blanc, Olivier Molendi-Coste, Laurent Pineau, Gianni Pasquetti, Laure Rolland, Charlène Carney, Florine Bornaque, Emilie Courty, Céline Gheeraert, Jérôme Eeckhoute, David Dombrowicz, Julie Kerr-Conte, François Pattou, Bart Staels, Philippe Froguel, Amélie Bonnefond, Jean-Sébastien Annicotte
ObjectiveThe pancreatic islets of Langerhans contain distinct cell subtypes including insulin-producing β cells. Although their cell-specific gene expression pattern defines their identity, the underlying molecular network driving this transcription
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77bfac845fa0f2d9e94c523988778578
https://doi.org/10.1101/2022.12.14.519294
https://doi.org/10.1101/2022.12.14.519294
Autor:
Manjula Vinod, Alexandre Berthier, Xavier Maréchal, Céline Gheeraert, Raphaël Boutry, Stéphane Delhaye, Jean-Sébastien Annicotte, Hélène Duez, Agnès Hovasse, Sarah Cianférani, David Montaigne, Jérôme Eeckhoute, Bart Staels, Philippe Lefebvre
Publikováno v:
Nature Cardiovascular Research
Nature Cardiovascular Research, 2022, pp.990-1005. ⟨10.1038/s44161-022-00148-z⟩
Nature Cardiovascular Research, 2022, pp.990-1005. ⟨10.1038/s44161-022-00148-z⟩
International audience; Myocardial ischemia–reperfusion injury (MIRI) induces life-threatening damages to the cardiac tissue, and pharmacological means to achieve cardioprotection are sorely needed. MIRI severity varies along the day–night cycle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ac438f024103466419cc8c3f6ee3698
https://www.hal.inserm.fr/inserm-03859910/document
https://www.hal.inserm.fr/inserm-03859910/document
Autor:
Audrey Deprince, David Dombrowicz, Artemii Nikitin, Bart Staels, Ann Driessen, Sébastien Fleury, An Verrijken, Denis A. Mogilenko, Hélène Dehondt, Samuel Pic, Luisa Vonghia, Bruno Derudas, Sven Francque, Joel T. Haas, Philippe Lefebvre, Luc Van Gaal, Olivier Molendi-Coste, Céline Gheeraert, Lucie Ducrocq-Geoffroy, Eloise Woitrain
Publikováno v:
NATURE METABOLISM
Nature Metabolism
Nature Metabolism, 2019, 1 (6), pp.604-614. ⟨10.1038/s42255-019-0076-1⟩
Nature Metabolism, Nature Publishing Group, 2019, 1 (6), pp.604-614. ⟨10.1038/s42255-019-0076-1⟩
Nature Metabolism
Nature Metabolism, 2019, 1 (6), pp.604-614. ⟨10.1038/s42255-019-0076-1⟩
Nature Metabolism, Nature Publishing Group, 2019, 1 (6), pp.604-614. ⟨10.1038/s42255-019-0076-1⟩
Luisa Vonghia and David Dombrowicz equally contributed to the work.; International audience; Progression of fatty liver to non-alcoholic steatohepatitis (NASH) is a rapidly growing health problem. The presence of inflammatory infiltrates in the liver