Acyclic nucleoside thiophosphonates as potent inhibitors of HIV and HBV replication

Autor: Bruno Canard, Johan Neyts, Céline Durafour, Loic Roux, Stéphane Priet, Nadine Payrot, Karine Barral, Fabien Zoulim, Karine Alvarez, Clément Weck, Jan Balzarini

Publikováno v: European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, Elsevier, 2011, 46 (9), pp.4281-4288. ⟨10.1016/j.ejmech.2011.06.034⟩
European Journal of Medicinal Chemistry, Elsevier, 2011, 46 (9), pp.4281-8. ⟨10.1016/j.ejmech.2011.06.034⟩
European Journal of Medicinal Chemistry, 2011, 46 (9), pp.4281-4288. ⟨10.1016/j.ejmech.2011.06.034⟩

9-[2-(Thiophosphonomethoxy)ethyl]adenine 3 and (R)-9-[2-(Thiophosphonomethoxy)propyl]adenine 4 were synthesized as the first thiophosphonate nucleosides bearing a sulfur atom at the α-position of the acyclic nucleoside phosphonates PMEA and PMPA. Th

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https://hal-amu.archives-ouvertes.fr/hal-02061721