The mitochondrially-localized nucleoside diphosphate kinase D (NME4) is a novel metastasis suppressor

Autor: Marie-Lise Lacombe, Frederic Lamarche, Olivier De Wever, Teresita Padilla-Benavides, Alyssa Carlson, Imran Khan, Anda Huna, Sophie Vacher, Claire Calmel, Céline Desbourdes, Cécile Cottet-Rousselle, Isabelle Hininger-Favier, Stéphane Attia, Béatrice Nawrocki-Raby, Joël Raingeaud, Christelle Machon, Jérôme Guitton, Morgane Le Gall, Guilhem Clary, Cedric Broussard, Philippe Chafey, Patrice Thérond, David Bernard, Eric Fontaine, Malgorzata Tokarska-Schlattner, Patricia Steeg, Ivan Bièche, Uwe Schlattner, Mathieu Boissan

Publikováno v: BMC Biology, Vol 19, Iss 1, Pp 1-29 (2021)

Abstract Background Mitochondrial nucleoside diphosphate kinase (NDPK-D, NME4, NM23-H4) is a multifunctional enzyme mainly localized in the intermembrane space, bound to the inner membrane. Results We constructed loss-of-function mutants of NDPK-D, l

Externí odkaz: https://doaj.org/article/64c3e3bcb5024675ac11f551606b20d8

Metal sensing and signal transduction by CnrX from Cupriavidus metallidurans CH34: role of the only methionine assessed by a functional, spectroscopic, and theoretical study

Autor: Juliette Trepreau, Géraldine Sarret, Isabelle Petit-Haertlein, Eve de Rosny, Eric Girard, Antoine P. Maillard, Dietrich H. Nies, Sandra Kuennemann, Cornelia Grosse, Jean-Marie Mouesca, Jacques Covès, Céline Desbourdes

Publikováno v: Metallomics
Metallomics, Royal Society of Chemistry, 2014, 6 (2), pp.263-273. ⟨10.1039/C3MT00248A⟩
Metallomics, 2014, 6 (2), pp.263-273. ⟨10.1039/C3MT00248A⟩

International audience; When CnrX, the periplasmic sensor protein in the CnrYXH transmembrane signal transduction complex of Cupriavidus metallidurans CH34, binds the cognate metal ions Ni(II) or Co(II), the ECF-type sigma factor CnrH is made availab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75b7a64d439c7c079a949eff7587eb86
https://doi.org/10.1039/c3mt00248a

Mitochondrial NM23-H4/NDPK-D Supports Cardiolipin Signaling to Eliminate Depolarized Mitochondria by Mitophagy

Autor: Alexandr A. Kapralov, Manish Verma, Vladimir A. Tyurina, Cécile Cottet-Rousselle, Jianfei Jiang, Valerian E. Kagan, Céline Desbourdes, Yulia Y. Tyurina, Zhentai Huang, Uwe Schlattner, Hülya Bayır, Marie-Lise Lacombe, Haider H. Dar, Rama K. Mallampalli, Charleen T. Chu

Publikováno v: 60th Annual Meeting of Biophysical Society
60th Annual Meeting of Biophysical Society, Feb 2016, Los Ageles, United States. 110 (3 suppl 1), pp.472a, 2016, Biophysical Journal. ⟨10.1016/j.bpj.2015.11.2528⟩

The well-established function of the hexameric intermembrane space protein, NDPK-D/NM23-H4, is phosphotransfer activity as a nucleoside diphosphate kinase. However, recent data revealed a second function in lipid signaling that is involved in mitopha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23c332d93af9df201d031eeff8c1ab76

Nucleoside diphosphate kinases fuel dynamin superfamily proteins with GTP for membrane remodeling

Autor: Ioan Lascu, Graça Raposo, Céline Desbourdes, Philippe Chavrier, Nathalie Sauvonnet, Thibault Lagache, Guillaume Montagnac, Jérôme Guitton, Qinfang Shen, Aurélien Roux, Marie-Lise Lacombe, Maryse Romao, Uwe Schlattner, Lorena Griparic, AlexanderM van der Bliek, Mathieu Boissan, Simona Polo

Publikováno v: Science
Science, American Association for the Advancement of Science, 2014, 344 (6191), pp.1510-1515. ⟨10.1126/science.1253768⟩
Science, Vol. 344, No 6191 (2014) pp. 1510-1515
Science, 2014, 344 (6191), pp.1510-1515. ⟨10.1126/science.1253768⟩

Supplying power: Right time, right place Cell membranes are very flexible and easily molded to shape; however, to physically pinch off a membrane vesicle from a membrane tube still requires power. A type of molecular machine known as dynamin is invol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7726ff13ddbb69fa06ced235e15f2ddc
https://hal.archives-ouvertes.fr/hal-01870066

Mitochondrial NM23-H4/NDPk-D is Multifunctional: Fueling Mitochondrial GTPase OPA1 and Triggering Mitophagy

Autor: Alexander M. van der Bliek, Guillaume Montagnac, Aurélien Roux, Lorena Griparic, Philippe Chavrier, Cécile Cottet-Rousselle, Uwe Schlattner, Yulia Y. Tyurina, Jianfei Jiang, Céline Desbourdes, Mathieu Boissan, Zhentai Huang, Malgorzata Tokarska-Schlattner, Valerian E. Kagan, Marie-Lise Lacombe

Publikováno v: ResearcherID
59th Annual Meeting of the Biophysical Society
59th Annual Meeting of the Biophysical Society, Feb 2015, Baltimore, United States. Elsevier, 108 (2 suppl 1), pp.369a, 2015, Biophysical Journal. ⟨10.1016/j.bpj.2014.11.2020⟩

NM23-H4/NDPK-D forms symmetrical homohexameric complexes in the mitochondrial inter-membrane space. The well-established function of NM23-H4 is phosphotransfer activity as a nucleoside diphosphate kinase, using mitochondrial ATP to regenerate NTPs, e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98c58321835def5926ff6370d5652458
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000362849400264&KeyUID=WOS:000362849400264