Persistence of Integrase-Deficient Lentiviral Vectors Correlates with the Induction of STING-Independent CD8+ T Cell Responses

Autor: Céline Cousin, Marine Oberkampf, Tristan Felix, Pierre Rosenbaum, Robert Weil, Sylvie Fabrega, Valeria Morante, Donatella Negri, Andrea Cara, Gilles Dadaglio, Claude Leclerc

Publikováno v: Cell Reports, Vol 26, Iss 5, Pp 1242-1257.e7 (2019)

Summary: Lentiviruses are among the most promising viral vectors for in vivo gene delivery. To overcome the risk of insertional mutagenesis, integrase-deficient lentiviral vectors (IDLVs) have been developed. We show here that strong and persistent s

Externí odkaz: https://doaj.org/article/066c2f9a277e49c2bf270907fe48d352

Dichotomy between factors inducing the immunosuppressive enzyme IL-4-induced gene 1 (IL4I1) in B lymphocytes and mononuclear phagocytes

Autor: Nadine Martin-Garcia, Marie-Line Puiffe, Véronique Baud, Jean-Pierre Farcet, Céline Cousin, Fanny Chereau, Valérie Molinier-Frenkel, Fanette Lasoudris, Jeanine Marquet, Flavia Castellano

Publikováno v: European Journal of Immunology
European Journal of Immunology, 2010, 40 (9), pp.2557-68. ⟨10.1002/eji.201040428⟩
European Journal of Immunology, Wiley-VCH Verlag, 2010, 40 (9), pp.2557-68. ⟨10.1002/eji.201040428⟩
European Journal of Immunology, Wiley-VCH Verlag, 2010, 40 (9), pp.2557-68. 〈10.1002/eji.201040428〉

International audience; MPhi and DC are key elements in the control of tissue homeostasis and response to insult. In this work, we demonstrate that MPhi and DC are the major producers of the phenylalanine catabolizing enzyme IL-4-induced gene 1 (IL4I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e78c48015042742fac607bf7e3562b4
https://doi.org/10.1002/eji.201040428

IL4I1 and tumor immunoresistance

Autor: Issam Abd-Alsamad, Armelle Prévost-Blondel, Nicolas Ortonne, Valérie Molinier-Frenkel, Nadine Martin-Garcia, Flavia Castellano, Fanette Lasoudris, Céline Cousin, Jean-Pierre Farcet

Publikováno v: European Journal of Immunology
European Journal of Immunology, 2011, 41 (6), pp.1629-38. ⟨10.1002/eji.201041119⟩
European Journal of Immunology, Wiley-VCH Verlag, 2011, 41 (6), pp.1629-38. 〈10.1002/eji.201041119〉
European Journal of Immunology, Wiley-VCH Verlag, 2011, 41 (6), pp.1629-38. ⟨10.1002/eji.201041119⟩

International audience; The L-phenylalanine oxidase IL4I1 inhibits T-cell proliferation in vitro through H(2) O(2) production, and is highly expressed in tumor-associated macrophages. IL4I1 is also detected by immunohistochemistry in neoplastic cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9571028c50583f9d199d28a327f61b7a
https://www.hal.inserm.fr/inserm-00604898/file/inserm-00604898_edited.pdf