Zobrazeno 1 - 10 of 58 pro vyhledávání: '"Céline Colacios"'
1
Akademický článek
Resistance of melanoma to immune checkpoint inhibitors is overcome by targeting the sphingosine kinase-1
Autor: Caroline Imbert, Anne Montfort, Marine Fraisse, Elie Marcheteau, Julia Gilhodes, Elodie Martin, Florie Bertrand, Marlène Marcellin, Odile Burlet-Schiltz, Anne Gonzalez de Peredo, Virginie Garcia, Stéphane Carpentier, Sophie Tartare-Deckert, Pierre Brousset, Philippe Rochaix, Florent Puisset, Thomas Filleron, Nicolas Meyer, Laurence Lamant, Thierry Levade, Bruno Ségui, Nathalie Andrieu-Abadie, Céline Colacios
Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
There are many patients who do not respond to immune checkpoint inhibitor (ICI) immunotherapy. Here, the authors show a significant negative correlation between sphingosine kinase-1 (SK1) expression and survival for ICI-treated melanoma patients, and
Externí odkaz: https://doaj.org/article/38bb744217484cb7ab770593454d6238
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2
Akademický článek
Anti-TNF, a magic bullet in cancer immunotherapy?
Autor: Anne Montfort, Carine Dufau, Céline Colacios, Nathalie Andrieu-Abadie, Thierry Levade, Thomas Filleron, Jean-Pierre Delord, Maha Ayyoub, Nicolas Meyer, Bruno Ségui
Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-4 (2019)
Abstract Immune checkpoint blockers (ICB) have revolutionized cancer therapy. However, complete response is observed in a minority of patients and most patients develop immune-related adverse events (irAEs). These include colitis, which can be treate
Externí odkaz: https://doaj.org/article/3e240457042741c09966d9f459323c66
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3
Akademický článek
TNFα blockade overcomes resistance to anti-PD-1 in experimental melanoma
Autor: Florie Bertrand, Anne Montfort, Elie Marcheteau, Caroline Imbert, Julia Gilhodes, Thomas Filleron, Philippe Rochaix, Nathalie Andrieu-Abadie, Thierry Levade, Nicolas Meyer, Céline Colacios, Bruno Ségui
Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Most melanoma patients do not respond to anti-PD1 therapy. Here, the authors show that TNFα blockade synergizes with anti-PD-1 by preventing anti-PD-1-induced CD8+ T cell death and TIM-3 expression on such cells.
Externí odkaz: https://doaj.org/article/a4452c1e969c432987f7e542b52dfbb2
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6
Akademický článek
Sphingomyelin Synthase 1 (SMS1) Downregulation Is Associated With Sphingolipid Reprogramming and a Worse Prognosis in Melanoma
Autor: Fatima Bilal, Anne Montfort, Julia Gilhodes, Virginie Garcia, Joëlle Riond, Stéphane Carpentier, Thomas Filleron, Céline Colacios, Thierry Levade, Ahmad Daher, Nicolas Meyer, Nathalie Andrieu-Abadie, Bruno Ségui
Publikováno v: Frontiers in Pharmacology, Vol 10 (2019)
Sphingolipid (SL) metabolism alterations have been frequently reported in cancer including in melanoma, a bad-prognosis skin cancer. In normal cells, de novo synthesized ceramide is mainly converted to sphingomyelin (SM), the most abundant SL, by sph
Externí odkaz: https://doaj.org/article/35281e352b514bb2bdc159ba35de8093
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7
Akademický článek
A Natural Variant of the Signaling Molecule Vav1 Enhances Susceptibility to Myasthenia Gravis and Influences the T Cell Receptor Repertoire
Autor: Isabelle Bernard, Antoine Sacquin, Sahar Kassem, Mehdi Benamar, Céline Colacios, Mylène Gador, Corine Pérals, Nicolas Fazilleau, Abdelhadi Saoudi
Publikováno v: Frontiers in Immunology, Vol 9 (2018)
The guanine nucleotide exchange factor Vav1 is essential for transducing T cell receptor (TCR) signals and plays an important role in T cell development and activation. Previous genetic studies identified a natural variant of Vav1 characterized by th
Externí odkaz: https://doaj.org/article/1d172c4b362b47fd81003dd19e718073
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8
Akademický článek
A Natural Variant of the T Cell Receptor-Signaling Molecule Vav1 Reduces Both Effector T Cell Functions and Susceptibility to Neuroinflammation.
Autor: Sahar Kassem, Guillaume Gaud, Isabelle Bernard, Mehdi Benamar, Anne S Dejean, Roland Liblau, Gilbert J Fournié, Céline Colacios, Bernard Malissen, Abdelhadi Saoudi
Publikováno v: PLoS Genetics, Vol 12, Iss 7, p e1006185 (2016)
The guanine nucleotide exchange factor Vav1 is essential for transducing T cell antigen receptor signals and therefore plays an important role in T cell development and activation. Our previous genetic studies identified a locus on rat chromosome 9 t
Externí odkaz: https://doaj.org/article/d8479a9b003e41b78eb0bbad0088f8e1
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9
Akademický článek
A spontaneous mutation of the rat Themis gene leads to impaired function of regulatory T cells linked to inflammatory bowel disease.
Autor: Marianne Chabod, Christophe Pedros, Lucille Lamouroux, Céline Colacios, Isabelle Bernard, Dominique Lagrange, Daniela Balz-Hara, Jean-Francois Mosnier, Christian Laboisse, Nathalie Vergnolle, Olivier Andreoletti, Marie-Paule Roth, Roland Liblau, Gilbert J Fournié, Abdelhadi Saoudi, Anne S Dejean
Publikováno v: PLoS Genetics, Vol 8, Iss 1, p e1002461 (2012)
Spontaneous or chemically induced germline mutations, which lead to Mendelian phenotypes, are powerful tools to discover new genes and their functions. Here, we report an autosomal recessive mutation that occurred spontaneously in a Brown-Norway (BN)
Externí odkaz: https://doaj.org/article/6dcffa93dca04eb58a5784b17141819b
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