Výsledky vyhledávání - "Céline Charrier"

Akademický článek

Apoptotic mesenchymal stromal cells support osteoclastogenesis while inhibiting multinucleated giant cells formation in vitro

Autor: Paul Humbert, Meadhbh Á. Brennan, Julien De Lima, Régis Brion, Annie Adrait, Céline Charrier, Bénédicte Brulin, Valérie Trichet, Yohann Couté, Frédéric Blanchard, Pierre Layrolle

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)

Abstract In bone regeneration induced by the combination of mesenchymal stromal cells (MSCs) and calcium-phosphate (CaP) materials, osteoclasts emerge as a pivotal cell linking inflammation and bone formation. Favorable outcomes are observed despite

Externí odkaz: https://doaj.org/article/8c0605303bff4042827151db8a18481c

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Akademický článek

TH1579, MTH1 inhibitor, delays tumour growth and inhibits metastases development in osteosarcoma model

Autor: Brice Moukengue, Hannah K Brown, Céline Charrier, Séverine Battaglia, Marc Baud'huin, Thibaut Quillard, Therese M Pham, Ioannis S Pateras, Vassilis G Gorgoulis, Thomas Helleday, Dominique Heymann, Ulrika Warpman Berglund, Benjamin Ory, Francois Lamoureux

Publikováno v: EBioMedicine, Vol 53, Iss , Pp - (2020)

ABSTRACT: Background: Osteosarcoma (OS) is the most common primary malignant bone tumour. Unfortunately, no new treatments are approved and over the last 30 years the survival rate remains only 30% at 5 years for poor responders justifying an urgent

Externí odkaz: https://doaj.org/article/4adcf80b973340c5acc405a66af0dad8

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Akademický článek

Ribosomopathies: New Therapeutic Perspectives

Autor: Emilien Orgebin, François Lamoureux, Bertrand Isidor, Céline Charrier, Benjamin Ory, Frédéric Lézot, Marc Baud’huin

Publikováno v: Cells, Vol 9, Iss 9, p 2080 (2020)

Ribosomopathies are a group of rare diseases in which genetic mutations cause defects in either ribosome biogenesis or function, given specific phenotypes. Ribosomal proteins, and multiple other factors that are necessary for ribosome biogenesis (rRN

Externí odkaz: https://doaj.org/article/06283ce7d2af4ad5a721287cd773d3b6

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Akademický článek

Implication of molecular vascular smooth muscle cell heterogeneity among arterial beds in arterial calcification.

Autor: Olivier Espitia, Mathias Chatelais, Marja Steenman, Céline Charrier, Blandine Maurel, Steven Georges, Rémi Houlgatte, Franck Verrecchia, Benjamin Ory, François Lamoureux, Dominique Heymann, Yann Gouëffic, Thibaut Quillard

Publikováno v: PLoS ONE, Vol 13, Iss 1, p e0191976 (2018)

Vascular calcification is a strong and independent predictive factor for cardiovascular complications and mortality. Our previous work identified important discrepancies in plaque composition and calcification types between carotid and femoral arteri

Externí odkaz: https://doaj.org/article/058f2ba2176a48dca805908cb2990c69

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Akademický článek

Osteoprotegerin, pericytes and bone-like vascular calcification are associated with carotid plaque stability.

Autor: Jean-Michel Davaine, Thibaut Quillard, Régis Brion, Olivier Lapérine, Béatrice Guyomarch, Thierry Merlini, Mathias Chatelais, Florian Guilbaud, Meadhbh Áine Brennan, Céline Charrier, Dominique Heymann, Yann Gouëffic, Marie-Françoise Heymann

Publikováno v: PLoS ONE, Vol 9, Iss 9, p e107642 (2014)

Background and purposeVascular calcification, recapitulating bone formation, has a profound impact on plaque stability. The aim of the present study was to determine the influence of bone-like vascular calcification (named osteoid metaplasia = OM) an

Externí odkaz: https://doaj.org/article/4b4a0f94d79845ea8e36fb623f213069

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Akademický článek

Imatinib mesylate exerts anti-proliferative effects on osteosarcoma cells and inhibits the tumour growth in immunocompetent murine models.

Autor: Bérengère Gobin, Gatien Moriceau, Benjamin Ory, Céline Charrier, Régis Brion, Frederic Blanchard, Françoise Redini, Dominique Heymann

Publikováno v: PLoS ONE, Vol 9, Iss 3, p e90795 (2014)

Osteosarcoma is the most common primary malignant bone tumour characterized by osteoid production and/or osteolytic lesions of bone. A lack of response to chemotherapeutic treatments shows the importance of exploring new therapeutic methods. Imatinib

Externí odkaz: https://doaj.org/article/fb2278d0ff004fd8976fdb84803705bf

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