Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Céline, Marionneau"'
Autor:
Jérôme Montnach, Maxime Lorenzini, Adrien Lesage, Isabelle Simon, Sébastien Nicolas, Eléonore Moreau, Céline Marionneau, Isabelle Baró, Michel De Waard, Gildas Loussouarn
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract The patch-clamp technique and more recently the high throughput patch-clamp technique have contributed to major advances in the characterization of ion channels. However, the whole-cell voltage-clamp technique presents certain limits that ne
Externí odkaz:
https://doaj.org/article/fc995879801249e6af526213e9a3435d
Autor:
Olfat A. Malak, Fayal Abderemane-Ali, Yue Wei, Fabien C. Coyan, Gilyane Pontus, David Shaya, Céline Marionneau, Gildas Loussouarn
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-18 (2020)
Abstract Prokaryotic NaV channels are tetramers and eukaryotic NaV channels consist of a single subunit containing four domains. Each monomer/domain contains six transmembrane segments (S1-S6), S1-S4 being the voltage-sensor domain and S5-S6 the pore
Externí odkaz:
https://doaj.org/article/c55713584dc441e5873be97cf8de9611
Autor:
Jérôme Clatot, Malcolm Hoshi, Xiaoping Wan, Haiyan Liu, Ankur Jain, Krekwit Shinlapawittayatorn, Céline Marionneau, Eckhard Ficker, Taekjip Ha, Isabelle Deschênes
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Voltage-gated sodium channels are expressed in excitable tissues and mutations have been linked to cardiac arrhythmias and channelopathies. Here the authors show that the sodium channel α-subunits interact to form a dimer and gate as dimer and that
Externí odkaz:
https://doaj.org/article/85a3e4c0115748e58575917074c2df76
Autor:
Estelle Renard, Richard D. Walton, David Benoist, Fabien Brette, Gilles Bru-Mercier, Sébastien Chaigne, Sabine Charron, Marion Constantin, Matthieu Douard, Virginie Dubes, Bastien Guillot, Thomas Hof, Julie Magat, Marine E. Martinez, Cindy Michel, Néstor Pallares-Lupon, Philippe Pasdois, Alice Récalde, Fanny Vaillant, Frédéric Sacher, Louis Labrousse, Julien Rogier, Florence Kyndt, Manon Baudic, Jean-Jacques Schott, Julien Barc, Vincent Probst, Marine Sarlandie, Céline Marionneau, Jesse L. Ashton, Mélèze Hocini, Michel Haïssaguerre, Olivier Bernus
Publikováno v:
JACC: Clinical Electrophysiology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18a9df3915db9039e2375100d0c86090
https://doi.org/10.1016/j.jacep.2023.03.009
https://doi.org/10.1016/j.jacep.2023.03.009
Autor:
Claude Zoukimian, Jérôme Montnach, Patrick Delmas, Nancy Osorio, Michel De Waard, Céline Marionneau, Sophie Burel, Massimo Mantegazza, Rachid Boukaiba, Sébastien Nicolas, Rémy Béroud, Michel Partiseti, Stephan De Waard
Publikováno v:
British Journal of Pharmacology
British Journal of Pharmacology, 2021, 178 (13), pp.2632-2650. ⟨10.1111/bph.15453⟩
British Journal of Pharmacology, Wiley, 2021, 178 (13), pp.2632-2650. ⟨10.1111/bph.15453⟩
British Journal of Pharmacology, 2021, 178 (13), pp.2632-2650. ⟨10.1111/bph.15453⟩
British Journal of Pharmacology, Wiley, 2021, 178 (13), pp.2632-2650. ⟨10.1111/bph.15453⟩
Background and purpose Protoxin II (ProTx II) is a high affinity gating modifier that is thought to selectively block the Nav 1.7 voltage-dependent Na+ channel, a major therapeutic target for the control of pain. We aimed at producing ProTx II analog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d552821fc41c4de2089019a359a9d01
https://doi.org/10.1111/bph.15453
https://doi.org/10.1111/bph.15453
Autor:
Vincent Portero, Solena Le Scouarnec, Zeineb Es‐Salah‐Lamoureux, Sophie Burel, Jean‐Baptiste Gourraud, Stéphanie Bonnaud, Pierre Lindenbaum, Floriane Simonet, Jade Violleau, Estelle Baron, Eléonore Moreau, Carol Scott, Stéphanie Chatel, Gildas Loussouarn, Thomas O'Hara, Philippe Mabo, Christian Dina, Hervé Le Marec, Jean‐Jacques Schott, Vincent Probst, Isabelle Baró, Céline Marionneau, Flavien Charpentier, Richard Redon
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 5, Iss 6 (2016)
BackgroundThe Brugada syndrome is an inherited cardiac arrhythmia associated with high risk of sudden death. Although 20% of patients with Brugada syndrome carry mutations in SCN5A, the molecular mechanisms underlying this condition are still largely
Externí odkaz:
https://doaj.org/article/b67e2535b2574e7c940289a9f00f97ea
Autor:
Fabien C Coyan, Fayal Abderemane-Ali, Mohamed Yassine Amarouch, Julien Piron, Jérôme Mordel, Céline S Nicolas, Marja Steenman, Jean Mérot, Céline Marionneau, Annick Thomas, Robert Brasseur, Isabelle Baró, Gildas Loussouarn
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e93255 (2014)
INTRODUCTION:Phosphatidylinositol-4,5-bisphosphate (PIP2) is a cofactor necessary for the activity of KCNQ1 channels. Some Long QT mutations of KCNQ1, including R243H, R539W and R555C have been shown to decrease KCNQ1 interaction with PIP2. A previou
Externí odkaz:
https://doaj.org/article/2457806624d04ecea1b5be87c18b48d5
Autor:
Jeanne M. Nerbonne, Pierre Marie Chevillard, Maxime Lorenzini, Dan Maloney, Lars S. Maier, Sophie Burel, Jonathan R. Silva, Bérangere Evrard, Céline Marionneau, Kiersten M. Ruff, Emily Wagner, Stefan Wagner, Camille Charriere, Rohit V. Pappu, Adrien Lesage, Raymond R. Townsend
Publikováno v:
Journal of General Physiology
Journal of General Physiology, Rockefeller University Press, 2021, 153 (2), pp.e202012646. ⟨10.1085/jgp.202012646⟩
The Journal of General Physiology
Journal of General Physiology, Rockefeller University Press, 2021, 153 (2), pp.e202012646. ⟨10.1085/jgp.202012646⟩
The Journal of General Physiology
Lorenzini et al. describe the native phosphorylation sites of NaV1.5 channels in mouse left ventricles. By analyzing expression and function of phosphosilent and phosphomimetic mutants, they identify phosphorylation hot spots regulating channel cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::010b69f26807dcd59479cc97d9197f9d
https://hal.archives-ouvertes.fr/hal-03113169
https://hal.archives-ouvertes.fr/hal-03113169
Autor:
Rohit V. Pappu, Emily Wagner, Sophie Burel, Lars S. Maier, Camille Charrière, Bérangère Evrard, Céline Marionneau, Maxime Lorenzini, Jonathan R. Silva, Raymond R. Townsend, Adrien Lesage, Kiersten M. Ruff, Stefan Wagner, Pierre-Marie Chevillard, Dan Maloney, Jeanne M. Nerbonne
Phosphorylation of NaV1.5 channels regulates cardiac excitability, yet the phosphorylation sites regulating channel function and the underlying mechanisms remain largely unknown. Using a systematic quantitative phosphoproteomic approach, we analyzed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7c18fc35faf43a54b777101015a8f52
https://doi.org/10.1101/2020.04.29.067835
https://doi.org/10.1101/2020.04.29.067835
Autor:
Maxime Lorenzini, Michel De Waard, Adrien Lesage, Céline Marionneau, Eléonore Moreau, Jérôme Montnach, Isabelle Baró, Isabelle Simon, Gildas Loussouarn, Sébastien Nicolas
Publikováno v:
Scientific Reports
Scientific Reports, Nature Publishing Group, 2021, ⟨10.1038/s41598-021-82077-8⟩
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Scientific Reports, Nature Publishing Group, 2021, ⟨10.1038/s41598-021-82077-8⟩
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
The patch-clamp technique and more recently the high throughput patch-clamp technique have contributed to major advances in the characterization of ion channels. However, the whole-cell voltage-clamp technique presents certain limits that need to be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a089d125a11d348f05e788c6e3a6ade
https://doi.org/10.1101/2020.04.27.062182
https://doi.org/10.1101/2020.04.27.062182