Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Céline, Hoffmann"'
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Cytotoxic lymphocytes (CLs), specifically cytotoxic T lymphocytes and natural killer cells, are indispensable guardians of the immune system and orchestrate the recognition and elimination of cancer cells. Upon encountering a cancer cell, CLs establi
Externí odkaz:
https://doaj.org/article/2ce692d133a94eb2bea516bfe5d57705
Autor:
Takouhie Mgrditchian, Joshua Brown-Clay, Céline Hoffmann, Tanja Müller, Liza Filali, Elena Ockfen, Xianqing Mao, Flora Moreau, Carla Pou Casellas, Tony Kaoma, Michel Mittelbronn, Clément Thomas
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
The actin cytoskeleton plays a critical role in cancer cell invasion and metastasis; however, the coordination of its multiple functions remains unclear. Actin dynamics in the cytoplasm control the formation of invadopodia, which are membrane protrus
Externí odkaz:
https://doaj.org/article/c2b8619594984cbea893d4b0fc76ae51
Autor:
Hannah Wurzer, Liza Filali, Céline Hoffmann, Max Krecke, Andrea Michela Biolato, Jérôme Mastio, Sigrid De Wilde, Jean Hugues François, Anne Largeot, Guy Berchem, Jérôme Paggetti, Etienne Moussay, Clément Thomas
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Natural killer (NK) cells are innate effector lymphocytes with strong antitumor effects against hematologic malignancies such as chronic lymphocytic leukemia (CLL). However, NK cells fail to control CLL progression on the long term. For effective lys
Externí odkaz:
https://doaj.org/article/6022f7d32a004eda80782d5d6124ada7
Autor:
Céline Hoffmann, Xianqing Mao, Joshua Brown-Clay, Flora Moreau, Antoun Al Absi, Hannah Wurzer, Barbara Sousa, Fernando Schmitt, Guy Berchem, Bassam Janji, Clément Thomas
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)
Abstract Hypoxia is a common feature of solid tumours that promotes invasion and metastatic dissemination. Invadopodia are actin-rich membrane protrusions that direct extracellular matrix proteolysis and facilitate tumour cell invasion. Here, we show
Externí odkaz:
https://doaj.org/article/9aa369442f8843179906f34893c25651
Autor:
Danielle Campiol Arruda, Anne-Marie Lachagès, Hélène Demory, Guillaume Escriou, René Lai-Kuen, Pierre-Yves Dugas, Céline Hoffmann, Stéphanie Bessoles, Guillaume Sarrabayrouse, Angelo Malachias, Stéphanie Finet, Pedro Lana Gastelois, Waldemar Augusto de Almeida Macedo, Armando da Silva Cunha, Pascal Bigey, Virginie Escriou
Publikováno v:
Journal of Controlled Release
Journal of Controlled Release, 2022, 350, pp.228-243. ⟨10.1016/j.jconrel.2022.08.030⟩
Journal of Controlled Release, 2022, 350, pp.228-243. ⟨10.1016/j.jconrel.2022.08.030⟩
International audience; Vectorized small interfering RNAs (siRNAs) are widely used to induce gene silencing. Among the delivery systems used, lipid-based particles are the most effective. Our objective was the development of novel lipid-polymer hybri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4092a10928f4d39baa56cc395caea4d1
https://hal-cnrs.archives-ouvertes.fr/hal-03764331/document
https://hal-cnrs.archives-ouvertes.fr/hal-03764331/document
Publikováno v:
Cells, Vol 8, Iss 5, p 463 (2019)
The immune system is a fundamental part of the tumor microenvironment. In particular, cytotoxic lymphocytes, such as cytolytic T cells and natural killer cells, control tumor growth and disease progression by interacting and eliminating tumor cells.
Externí odkaz:
https://doaj.org/article/981bddc76e3a429eb85dfe4c78b23e9c
Autor:
Pascal Roux, Virginie Escriou, Judith Aron-Wisnewsky, Nour El Houda Djerir, Christine Charrueau, Isabelle Brocheriou, Céline Hoffmann, Anne Danckaert, Karine Clément, Fabienne Foufelle, Anne-Marie Lachagès, Frédéric Charlotte, Vlad Ratziu, Julien Fernandes, Bernard Hainque, Pascal Bigey, Dominique Bonnefont-Rousselot
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports
Scientific Reports, Nature Publishing Group, 2020, 10 (1), pp.3850. ⟨10.1038/s41598-020-60615-0⟩
Scientific Reports, 2020, 10 (1), pp.3850. ⟨10.1038/s41598-020-60615-0⟩
Scientific Reports
Scientific Reports, Nature Publishing Group, 2020, 10 (1), pp.3850. ⟨10.1038/s41598-020-60615-0⟩
Scientific Reports, 2020, 10 (1), pp.3850. ⟨10.1038/s41598-020-60615-0⟩
Hepatic fibrosis is a major consequence of chronic liver disease such as non-alcoholic steatohepatitis which is undergoing a dramatic evolution given the obesity progression worldwide, and has no treatment to date. Hepatic stellate cells (HSCs) play
Autor:
Takouhie, Mgrditchian, Gabriele, Sakalauskaite, Tanja, Müller, Céline, Hoffmann, Clément, Thomas
Publikováno v:
International review of cell and molecular biology. 360
Invadopodia are actin-rich membrane protrusions that facilitate cancer cell dissemination by focusing on proteolytic activity and clearing paths for migration through physical barriers, such as basement membranes, dense extracellular matrices, and en
Autor:
Céline Hoffmann, Valérie Trichet, Waldemar A. A. Macedo, Armando da Silva Cunha, Angelo Malachias de Souza, Ismael González, Luis A. Córdova, Gracielle Ferreira Andrade, Stéphanie Finet, Danielle Campiol Arruda, Virginie Escriou, Pascal Bigey
Publikováno v:
Journal of Colloid and Interface Science
Journal of Colloid and Interface Science, Elsevier, 2019, 540, pp.342-353. ⟨10.1016/j.jcis.2019.01.043⟩
Journal of Colloid and Interface Science, 2019, 540, pp.342-353. ⟨10.1016/j.jcis.2019.01.043⟩
Journal of Colloid and Interface Science, Elsevier, 2019, 540, pp.342-353. ⟨10.1016/j.jcis.2019.01.043⟩
Journal of Colloid and Interface Science, 2019, 540, pp.342-353. ⟨10.1016/j.jcis.2019.01.043⟩
International audience; Vectorized small interfering RNAs (siRNAs) are widely used to induce specific mRNA degradation in the intracellular compartment of eukaryotic cells. Recently, we developed efficient cationic lipid-based siRNA vectors (siRNA li
Autor:
Céline Hoffmann, Xianqing Mao, Rémi Petrolli, Carla Pou Casellas, Antoun Al Absi, Clément Thomas, Flora Moreau, Monika Dieterle, Jean Paul Thiery, Guy Berchem, Hannah Wurzer, Salem Chouaib, Joshua D. Brown-Clay, Coralie L. Guerin, Bassam Janji
Publikováno v:
Cancer Research. 78:5631-5643
Elucidation of the underlying molecular mechanisms of immune evasion in cancer is critical for the development of immunotherapies aimed to restore and stimulate effective antitumor immunity. Here, we evaluate the role of the actin cytoskeleton in bre