Off-Target Integron Activity Leads to Rapid Plasmid Compensatory Evolution in Response to Antibiotic Selection Pressure

Autor: Célia Souque, José A. Escudero, R. Craig MacLean

Publikováno v: mBio, Vol 14, Iss 2 (2023)

ABSTRACT Integrons are mobile genetic elements that have played an important role in the dissemination of antibiotic resistance. Under stress, the integron can generate combinatorial variation in resistance cassette expression by cassette reshuffling

Externí odkaz: https://doaj.org/article/faef6863f8724623a7797566f2189912

Macropinosomes are Key Players in Early Shigella Invasion and Vacuolar Escape in Epithelial Cells.

Autor: Allon Weiner, Nora Mellouk, Noelia Lopez-Montero, Yuen-Yan Chang, Célia Souque, Christine Schmitt, Jost Enninga

Publikováno v: PLoS Pathogens, Vol 12, Iss 5, p e1005602 (2016)

Intracellular pathogens include all viruses, many bacteria and parasites capable of invading and surviving within host cells. Key to survival is the subversion of host cell pathways by the pathogen for the purpose of propagation and evading the immun

Externí odkaz: https://doaj.org/article/ffcbe349c1fd45a58116ae1d081f392a

Understanding and managing uncertainty and variability for wastewater monitoring beyond the pandemic: Lessons learned from the United Kingdom National COVID-19 Surveillance Programmes

Autor: Anna Lo Jacomo, Mario Morvan, Vanessa Speight, Behnam Firoozi Nejad, Jasmine M. S. Grimsley, David L. Jones, Elena Armenise, Marcos Quintela-Baluja, Till Hoffmann, David W. Graham, Barbara Kasprzyk-Hordern, Kata Farkas, Cormac McSparron, Matthew J. Wade, Zhou Fang, Deidre F Gilpin, Chris J Lilley, Andrew C. Singer, John W. McGrath, Célia Souque, Alwyn Hart, Katherine J Jackson, Graeme J Cameron, Andrew J. Weightman, David I. Walker, Chris Sweetapple, Adrian M I Roberts, Joshua T. Bunce, Glenn Watts, Jennifer McKinley, Mathew R. Brown

Publikováno v: Wade, M, McKinley, J, McGrath, J, Gilpin, D, McSparron, C & Firoozi Nejad, B 2022, ' Understanding and managing uncertainty and variability for wastewater monitoring beyond the pandemic: Lessons learned from the United Kingdom National COVID-19 Surveillance Programmes ', Journal of Hazardous Materials, vol. 424, Part B, no. 127456 . https://doi.org/10.1016/j.jhazmat.2021.127456
Journal of Hazardous Materials

The COVID-19 pandemic has put unprecedented pressure on public health resources around the world. From adversity, opportunities have arisen to measure the state and dynamics of human disease at a scale not seen before. In the United Kingdom, the evid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ac41c495193a22efab33f094dfa127f
https://pure.qub.ac.uk/en/publications/understanding-and-managing-uncertainty-and-variability-for-wastewater-monitoring-beyond-the-pandemic-lessons-learned-from-the-united-kingdom-national-covid19-surveillance-programmes(01e9cb72-1e6b-4b97-bbf2-d8720f60f704).html

Author response: Integron activity accelerates the evolution of antibiotic resistance

Autor: R. Craig MacLean, José Antonio Escudero, Célia Souque

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b795e6125c04eae4efa4c570c7333623
https://doi.org/10.7554/elife.62474.sa2

Estimating SARS-CoV-2 prevalence from large-scale wastewater surveillance: insights from combined analysis of 44 sites in England

Autor: Andrew C. Singer, Matthew J. Wade, Mario Morvan, Koen Pouwels, Andrew Engeli, Célia Souque, Jasmine M. S. Grimsley, Kathleen O'Reilly, Joshua T. Bunce, Leon Danon, Anna Lo Jacomo, Till Hoffmann

Publikováno v: International Journal of Infectious Diseases. 116:S24

Accurate surveillance of the COVID-19 pandemic can be weakened by under-reporting of cases, particularly due to asymptomatic or pre-symptomatic infections, resulting in bias. Quantification of SARS-CoV-2 RNA in wastewater (WW) can be used to infer in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6f75ac26ea10aadf458b002ebc4f2e9
https://doi.org/10.1016/j.ijid.2021.12.057