Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Cédric Mongellaz"'
Autor:
Cédric Mongellaz, Rita Vicente, Lenora M. Noroski, Nelly Noraz, Valérie Courgnaud, Javier Chinen, Emilia Faria, Valérie S. Zimmermann, Naomi Taylor
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionZAP-70, a protein tyrosine kinase recruited to the T cell receptor (TCR), initiates a TCR signaling cascade upon antigen stimulation. Mutations in the ZAP70 gene cause a combined immunodeficiency characterized by low or absent CD8+ T cell
Externí odkaz:
https://doaj.org/article/9b8b9c74f3a9402ea679547b0d87cb55
Autor:
Maria I. Matias, Carmen S. Yong, Amir Foroushani, Chloe Goldsmith, Cédric Mongellaz, Erdinc Sezgin, Kandice R. Levental, Ali Talebi, Julie Perrault, Anais Rivière, Jonas Dehairs, Océane Delos, Justine Bertand-Michel, Jean-Charles Portais, Madeline Wong, Julien C. Marie, Ameeta Kelekar, Sandrina Kinet, Valérie S. Zimmermann, Ilya Levental, Laurent Yvan-Charvet, Johannes V. Swinnen, Stefan A. Muljo, Hector Hernandez-Vargas, Saverio Tardito, Naomi Taylor, Valérie Dardalhon
Publikováno v:
Cell Reports, Vol 37, Iss 5, Pp 109911- (2021)
Summary: Suppressive regulatory T cell (Treg) differentiation is controlled by diverse immunometabolic signaling pathways and intracellular metabolites. Here we show that cell-permeable α-ketoglutarate (αKG) alters the DNA methylation profile of na
Externí odkaz:
https://doaj.org/article/0c8c5ea249b7400aa1ce379f1a846ac3
Autor:
Julie Perrault, Anais Rivière, Chloe Goldsmith, Jonas Dehairs, Cédric Mongellaz, Laurent Yvan-Charvet, Naomi Taylor, Valérie S. Zimmermann, Saverio Tardito, Maria I. Matias, Valerie Dardalhon, Océane Delos, Amir Foroushani, Kandice R. Levental, Stefan A. Muljo, Sandrina Kinet, Ilya Levental, Hector Hernandez-Vargas, Ali Talebi, Jean-Charles Portais, Justine Bertand-Michel, Madeline Wong, Ameeta Kelekar, Julien C. Marie, Johannes V. Swinnen, Carmen S M Yong, Erdinc Sezgin
Publikováno v:
Cell Reports
Cell Reports, 2021, 37 (5), pp.109911. ⟨10.1016/j.celrep.2021.109911⟩
Cell Rep
Cell Reports, Vol 37, Iss 5, Pp 109911-(2021)
Cell Reports, 2021, 37 (5), pp.109911. ⟨10.1016/j.celrep.2021.109911⟩
Cell Rep
Cell Reports, Vol 37, Iss 5, Pp 109911-(2021)
Suppressive regulatory T cell (Treg) differentiation is controlled by diverse immunometabolic signaling pathways and intracellular metabolites. Here we show that cell-permeable α-ketoglutarate (αKG) alters the DNA methylation profile of naive CD4 T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56a0285e83f2c785c903977fe07dec51
https://lirias.kuleuven.be/handle/20.500.12942/691431
https://lirias.kuleuven.be/handle/20.500.12942/691431
Autor:
Anne Sirvent, Claire Lozano, Cédric Mongellaz, Guillaume Cartron, Hanane Guedon, François Van Laethem, Adeline Quintard, Mehdi Benzaoui, John De Vos, Aurélie Conte, Laura Platon, Jean-Jacques Tudesq, Delphine De Verbizier, Tarik Kanouni, Xavier Ayrignac, Patrice Ceballos, Chris Serrand, Mickael François, Emmanuelle Tchernonog, Eve Gehlkopf, Naomi Taylor, Valerie Dardalhon, Sylvain Lamure, Caroline Bret, Charles Herbaux, Philippe Quittet
Publikováno v:
Cancers, Vol 13, Iss 4279, p 4279 (2021)
Cancers
Cancers, MDPI, 2021, 13 (17), pp.4279. ⟨10.3390/cancers13174279⟩
Volume 13
Issue 17
Cancers
Cancers, MDPI, 2021, 13 (17), pp.4279. ⟨10.3390/cancers13174279⟩
Volume 13
Issue 17
CD19-directed CAR T-cells have been remarkably successful in treating patients with relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL) and transformed follicular lymphoma (t-FL). In this cohort study, we treated 60 patients with axicabta
Autor:
Marc Sitbon, Michaela Fontenay, Marie Daumur, Julien Papoin, Naomi Taylor, Hongxia Yan, Ira Phadke, Anne-Sophie Dumé, Sandrina Kinet, Narla Mohandas, Valérie S. Zimmermann, Phuong-Nhi Bories, Xiuli An, Ruhi Deshmukh, Manuela Romano, Pedro Gonzalez-Menendez, Xiaoli Qu, Valerie Dardalhon, Cédric Mongellaz, Saverio Tardito, Patrick G. Gallagher, Leal Oburoglu, Lionel Blanc
Publikováno v:
Cell Reports
Cell Reports, Elsevier Inc, 2021, 34 (5), pp.108723. ⟨10.1016/j.celrep.2021.108723⟩
Cell Rep
Cell Reports, Elsevier Inc, 2021, 34 (5), pp.108723. ⟨10.1016/j.celrep.2021.108723⟩
Cell Rep
The metabolic changes controlling the stepwise differentiation of hematopoietic stem and progenitor cells (HSPCs) to mature erythrocytes are poorly understood. Here, we show that HSPC development to an erythroid-committed proerythroblast results in a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28ccb8919a4bd55b40eb15cb7db34acc
https://hal.archives-ouvertes.fr/hal-03161590
https://hal.archives-ouvertes.fr/hal-03161590
Autor:
Madeline Wong, Ilya Levental, Kandice R. Levental, Anais Rivière, Ali Talebi, Erdinc Sezgin, Naomi Taylor, Laurent Yvan-Charvet, Johannes V. Swinnen, Saverio Tardito, Valérie S. Zimmermann, Valerie Dardalhon, Stefan A. Muljo, Jonas Dehair, Amir Foroushani, Carmen S M Yong, Cédric Mongellaz, Sandrina Kinet, Maria I. Matias, Julie Perrault
Publikováno v:
SSRN Electronic Journal.
Suppressive regulatory T cell (Treg) differentiation is controlled by diverse immunometabolic signaling pathways. However, the impact of intracellular metabolites on Treg fate has not been well explored. Here we show that the α-ketoglutarate (αKG)
Autor:
Valerie Dardalhon, Sandrina Kinet, Naomi Taylor, Madeline Wong, J. Dehair, Ilya Levental, Erdinc Sezgin, Maria I. Matias, Cédric Mongellaz, Stefan A. Muljo, Valérie S. Zimmermann, Carmen S M Yong, Triantafyllos Chavakis, Johan Swinnen, Laurent Yvan-Charvet, Kandice R. Levental, Amir Foroushani, Saverio Tardito, Ali Talebi
The differentiation of CD4 T cells to a specific effector fate is metabolically regulated, integrating glycolysis and mitochondrial oxidative phosphorylation (OXPHOS) with transcriptional and epigenetic changes. OXPHOS is tightly coordinated with the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4a581548ca0aa1bcde00c6c0e039b91
https://doi.org/10.1101/2020.08.24.256560
https://doi.org/10.1101/2020.08.24.256560
Autor:
Cédric Mongellaz, Saverio Tardito, Daouda Abba Moussa, Thomas J. Hope, Valerie Dardalhon, Leal Oburoglu, Isabelle Clerc, Naomi Taylor, Zoi Vahlas, Marc Sitbon
Publikováno v:
Nat Metab
Nature Metabolism
Nature Metabolism, Nature Publishing Group, 2019, 1 (7), pp.717-730. ⟨10.1038/s42255-019-0084-1⟩
Nature Metabolism
Nature Metabolism, Nature Publishing Group, 2019, 1 (7), pp.717-730. ⟨10.1038/s42255-019-0084-1⟩
The susceptibility of CD4 T cells to human immunodeficiency virus 1 (HIV-1) infection is regulated by glucose and glutamine metabolism, but the relative contributions of these nutrients to infection are not known. Here we show that glutaminolysis is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb84ed3120ee13c8b19a785405c457f1
https://europepmc.org/articles/PMC7199465/
https://europepmc.org/articles/PMC7199465/
Autor:
Marco, Craveiro, Gaspard, Cretenet, Cédric, Mongellaz, Maria I, Matias, Olivier, Caron, Maria C Pedroso, de Lima, Valérie S, Zimmermann, Eric, Solary, Valérie, Dardalhon, Vjekoslav, Dulić, Naomi, Taylor
Publikováno v:
Science signaling. 10(501)
The polyphenol resveratrol activates the deacetylase Sirt1, resulting in various antioxidant, chemoprotectant, neuroprotective, cardioprotective, and anti-inflammatory properties. We found that at high concentrations of resveratrol, human CD4
Resveratrol stimulates the metabolic reprogramming of human CD4+T cells to enhance effector function
Autor:
Naomi Taylor, Olivier Caron, Valerie Dardalhon, Marco Craveiro, Vjekoslav Dulic, Maria C. Pedroso de Lima, Cédric Mongellaz, Maria I. Matias, Eric Solary, Valérie S. Zimmermann, Gaspard Cretenet
Publikováno v:
Science Signaling. 10
The polyphenol resveratrol activates the deacetylase Sirt1, resulting in various antioxidant, chemoprotectant, neuroprotective, cardioprotective, and anti-inflammatory properties. We found that at high concentrations of resveratrol, human CD4 + T cel