First-in-human study of 99mTc-labeled fucoidan, a SPECT tracer targeting P-selectin

Autor: Reindert F. Oostveen, Kang H. Zheng, Yannick Kaiser, Nick S. Nurmohamed, Jeffrey Kroon, Tim C. de Wit, Edwin Poel, Joel Aerts, Francois Rouzet, Erik S. G. Stroes, Didier Letourneur, Hein J. Verberne, Cédric Chauvierre, Mia R. Ståhle

Publikováno v: EJNMMI Research, Vol 14, Iss 1, Pp 1-9 (2024)

Abstract Background Activation of endothelial cells and platelets in atherothrombosis is characterized by upregulation of P-selectin. As a consequence, P-selectin represents a potential target for molecular imaging to identify thrombosis at an early

Externí odkaz: https://doaj.org/article/34a2387182cc4b73afcd6d215acffb5e

Purification of a Low Molecular Weight Fucoidan for SPECT Molecular Imaging of Myocardial Infarction

Autor: Pierre Saboural, Frédéric Chaubet, Francois Rouzet, Faisal Al-Shoukr, Rana Ben Azzouna, Nadia Bouchemal, Luc Picton, Liliane Louedec, Murielle Maire, Lydia Rolland, Guy Potier, Dominique Le Guludec, Didier Letourneur, Cédric Chauvierre

Publikováno v: Marine Drugs, Vol 12, Iss 9, Pp 4851-4867 (2014)

Fucoidans constitute a large family of sulfated polysaccharides with several biochemical properties. A commercial fucoidan from brown algae, containing low molecular weight polysaccharidic species constituted of l-fucose, uronic acids and sulfate gro

Externí odkaz: https://doaj.org/article/ac8754790b0d4dba880ac02005549cb8

Microbubbles for human diagnosis and therapy

Autor: Louise Fournier, Thibault de La Taille, Cédric Chauvierre

Publikováno v: Biomaterials. 294:122025

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6862598765d5d7801d57d2d9fb5dd3cb
https://doi.org/10.1016/j.biomaterials.2023.122025

Roadmap on nanomedicine

Autor: Didier Letourneur, Roy van der Meel, Anna Lisa Palange, Daniele Di Mascolo, S. Moein Moghimi, Z. Shadi Farhangrazi, Dan Peer, Netanel Korin, Jun-Jie Zhu, Zhen Gu, Zhaowei Chen, Twan Lammers, Zejun Wang, Tingxizi Liang, Fabian Kiessling, Daniel Rosenblum, Paolo Decuzzi, Kenneth A. Howard, Cédric Chauvierre, Purnima Naresh Manghnani

Publikováno v: Nanotechnology
Nanotechnology, Institute of Physics, 2021, 32 (1), pp.012001. ⟨10.1088/1361-6528/abaadb⟩
Decuzzi, P, Peer, D, Di Mascolo, D, Palange, A L, Manghnani, P N, Moein Moghimi, S, Shadi Farhangrazi, Z, Howard, K A, Rosenblum, D, Liang, T, Chen, Z, Wang, Z, Zhu, J J, Gu, Z, Korin, N, Letourneur, D, Chauvierre, C, van der Meel, R, Kiessling, F & Lammers, T 2021, ' Roadmap on nanomedicine ', Nanotechnology, vol. 32, no. 1, 012001 . https://doi.org/10.1088/1361-6528/abaadb

International audience; Since the launch of the Alliance for Nanotechnology in Cancer by the National Cancer Institute in late 2004, several similar initiatives have been promoted all over the globe with the intention of advancing the diagnosis, trea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c865be8f8c9c932fd4fc2ffec44511fd
https://europepmc.org/articles/PMC7612035/

Gd(DOTA)-grafted submicronic polysaccharide-based particles functionalized with fucoidan as potential MR contrast agent able to target human activated platelets

Autor: Elise Gobin, Didier Le Cerf, Laura Marcela Forero Ramirez, Rachida Aid-Launais, Fernanda C. Moraes, Frédéric Chaubet, Didier Letourneur, Luc Picton, Clément Journé, Cédric Chauvierre

Publikováno v: Carbohydrate Polymers
Carbohydrate Polymers, Elsevier, 2020, 245, pp.116457. ⟨10.1016/j.carbpol.2020.116457⟩

International audience; Early detection of thrombotic events remains a big medical challenge. Dextran-based submicronic particles bearing Gd(DOTA) groups and functionalized with fucoidan have been produced via a simple and green water-in-oil emulsifi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6196112956dd67f9813b9b84d2877dc7
https://hal.archives-ouvertes.fr/hal-03022476