Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Cédric Castrogiovanni"'
Autor:
Aurélie Diman, Gaël Panis, Cédric Castrogiovanni, Julien Prados, Bastien Baechler, Michel Strubin
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Beyond its essential roles in ensuring faithful chromosome segregation and genomic stability, the human Smc5/6 complex acts as an antiviral factor. It binds to and impedes the transcription of extrachromosomal DNA templates; an ability which
Externí odkaz:
https://doaj.org/article/102454fb40ea491b972ca2cae402cd59
Autor:
Cédric Castrogiovanni, Alessio V. Inchingolo, Jonathan U. Harrison, Damian Dudka, Onur Sen, Nigel J. Burroughs, Andrew D. McAinsh, Patrick Meraldi
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Microtubules are built from GDP-tubulin lattices with small GTP caps at their plus-ends. Here, the authors reveal that microtubules that attach to kinetochores in mitosis contain, in addition to the GTP-cap and the GDP-lattices, a dynamic micron-size
Externí odkaz:
https://doaj.org/article/7374639fc1bf4c5e9e3d04d7bba621f4
Autor:
Aurélie Diman, Gaël Panis, Cédric Castrogiovanni, Julien Prados, Bastien Baechler, Michel Strubin
SummaryBeyond its essential roles in ensuring faithful chromosome segregation and genomic stability, the human Smc5/6 complex acts as an antiviral factor. It binds to and impedes the transcription of extrachromosomal DNA templates; an ability which i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4583270c26a72960bf35540ed68d4a4
https://doi.org/10.1101/2023.05.04.539344
https://doi.org/10.1101/2023.05.04.539344
Autor:
Patrick Meraldi, Cédric Castrogiovanni
Publikováno v:
Curr Biol
The kinetochore links chromosomes to spindle microtubules to drive chromosome segregation at cell division. While we know nearly all mammalian kinetochore proteins, how these give rise to the strong yet dynamic microtubule attachments required for fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8961960d5a4416457d2a265474340a1
https://doi.org/10.1016/j.cub.2022.05.045
https://doi.org/10.1016/j.cub.2022.05.045
Publikováno v:
Apoptosis
Mitosis, under the control of the microtubule-based mitotic spindle, is an attractive target for anti-cancer treatments, as cancer cells undergo frequent and uncontrolled cell divisions. Microtubule targeting agents that disrupt mitosis or single mol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fb49587b306420c3ac67825b50cbee3
https://doi.org/10.1007/s10495-021-01671-3
https://doi.org/10.1007/s10495-021-01671-3
Autor:
Patrick Meraldi, Nigel J. Burroughs, Cédric Castrogiovanni, Andrew D. McAinsh, Alessio Inchingolo, Jonathan U. Harrison, Damian Dudka, Onur Sen
Current models infer that the microtubule-based mitotic spindle is built from GDP-tubulin with small GTP caps at microtubule plus-ends, including those that attach to kinetochores (K-fibres). Here we reveal that K-fibres additionally contain a dynami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ed1b5eec863bcf2211c24a62e3011ff
https://doi.org/10.1101/2021.07.23.453504
https://doi.org/10.1101/2021.07.23.453504
Publikováno v:
Castrogiovanni, C, Waterschoot, B, De Backer, O & Dumont, P 2018, ' Serine 392 phosphorylation modulates p53 mitochondrial translocation and transcription-independent apoptosis ', Cell death and differentiation, vol. 25, no. 1, pp. 190-203 . https://doi.org/10.1038/cdd.2017.143
The tumor suppressor p53 is a key regulator of apoptosis induced by various cellular stresses. p53 can induce apoptosis by two mechanisms. First, p53 acts as a transcription factor inducing and repressing pro-apoptotic and anti-apoptotic targets gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::495f93b1874f1e255209394ba0631f5f
https://doi.org/10.1038/cdd.2017.143
https://doi.org/10.1038/cdd.2017.143
Autor:
Cédric Castrogiovanni, Marchien G. Dallinga, Andrea Weiss, Ingeborg Klaassen, Magdalena Rausch, Judy R. van Beijnum, Patrycja Nowak-Sliwinska, Patrick Meraldi, Marijana Miljkovic-Licina, Robert H. Berndsen
Publikováno v:
British Journal of Cancer
British Journal of Cancer, Vol. 121, No 2 (2019) pp. 139-149
British Journal of Cancer, 121(2), 139-149. Nature Publishing Group
British journal of cancer, 121(2), 139-149. Nature Publishing Group
Berndsen, R H, Castrogiovanni, C D, Weiss, A, Rausch, M, Dallinga, M G, Miljkovic-Licina, M, Klaassen, I, Meraldi, P, van Beijnum, J R & Nowak-Sliwinska, P 2019, ' Anti-angiogenic effects of crenolanib are mediated by mitotic modulation independently of PDGFR expression ', British Journal of Cancer, vol. 121, no. 2, pp. 139-149 . https://doi.org/10.1038/s41416-019-0498-2
British Journal of Cancer, Vol. 121, No 2 (2019) pp. 139-149
British Journal of Cancer, 121(2), 139-149. Nature Publishing Group
British journal of cancer, 121(2), 139-149. Nature Publishing Group
Berndsen, R H, Castrogiovanni, C D, Weiss, A, Rausch, M, Dallinga, M G, Miljkovic-Licina, M, Klaassen, I, Meraldi, P, van Beijnum, J R & Nowak-Sliwinska, P 2019, ' Anti-angiogenic effects of crenolanib are mediated by mitotic modulation independently of PDGFR expression ', British Journal of Cancer, vol. 121, no. 2, pp. 139-149 . https://doi.org/10.1038/s41416-019-0498-2
Background: Crenolanib is a tyrosine kinase inhibitor targeting PDGFR-α, PDGFR-β and Fms related tyrosine kinase-3 (FLT3) that is currently evaluated in several clinical trials. Although platelet-derived growth factor receptor (PDGFR) signalling pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d349204d6fb97ac07ef162a6ae420bb9
https://pubmed.ncbi.nlm.nih.gov/31235865
https://pubmed.ncbi.nlm.nih.gov/31235865
Publikováno v:
Current Biology, Vol. 29, No 21 (2019) pp. 3563-3578.e6
During mitosis, centrosomes affect the length of kinetochore fibers (k-fibers) and the stability of kinetochore-microtubule attachments, implying that they regulate k-fiber dynamics. However, the exact cellular and molecular mechanisms of this regula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c2661805d2a8eb00a889ce417741512
https://pubmed.ncbi.nlm.nih.gov/31668617
https://pubmed.ncbi.nlm.nih.gov/31668617
Autor:
Béranger Waterschoot, Patrick Dumont, Cédric Castrogiovanni, Olivier De Backer, Marie Vandaudenard
Following a genotoxic stress, the tumor suppressor p53 translocates to mitochondria to take part in direct induction of apoptosis, via interaction with BCL-2 family members such as BAK and BAX. We determined the kinetics of the mitochondrial transloc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63c330660af1b608766f8b19130cf304
https://europepmc.org/articles/PMC4623441/
https://europepmc.org/articles/PMC4623441/