Tolerability and efficacy of adjunctive brivaracetam in adults with focal seizures by concomitant antiseizure medication use: Pooled results from three phase 3 trials

Autor: Philippe Ryvlin, Svetlana Dimova, Sami Elmoufti, Florin Floricel, Cédric Laloyaux, Xavier Nondonfaz, Victor Biton

Publikováno v: Ryvlin, P, Dimova, S, Elmoufti, S, Floricel, F, Laloyaux, C, Nondonfaz, X & Biton, V 2022, ' Tolerability and efficacy of adjunctive brivaracetam in adults with focal seizures by concomitant antiseizure medication use : Pooled results from three phase 3 trials ', Epilepsia, vol. 63, no. 8, pp. 2024-2036 . https://doi.org/10.1111/epi.17304

Objective: This study was undertaken to evaluate safety/tolerability and efficacy of adjunctive brivaracetam (BRV) in patients on one or two concomitant antiseizure medications (ASMs) and in patients on one specific concomitant ASM. Methods: Post hoc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe708e073149db2d42b0072ca0a277ba
https://pubmed.ncbi.nlm.nih.gov/35582748

Change Blindness to Gradual Changes in Facial Expressions

Autor: Elodie David, Cédric Laloyaux, Christel Devue, Axel Cleeremans

Publikováno v: Psychologica Belgica, Vol 46, Iss 4, Pp 253-268 (2006)

Change blindness – our inability to detect changes in a stimulus – occurs even when the change takes place gradually, without disruption (Simons, Franconeri, & Reimer, 2000). Such gradual changes are more difficult to detect than changes that inv

Externí odkaz: https://doaj.org/article/dc3f5c2e77b1448aa6a6a2bfc80da6c8

Behavioral adverse events with brivaracetam, levetiracetam, perampanel, and topiramate: A systematic review

Autor: Manuel Toledo, John M. Stern, Joseph I Sirven, Patricia A. Zipfel, Kristen Ricchetti-Masterson, Pavel Klein, Brien J. Smith, Brian D. Moseley, Henrik Klitgaard, Bernhard J. Steinhoff, Cédric Laloyaux, Vicente Villanueva, Felix Rosenow

Publikováno v: Epilepsybehavior : EB. 118

Purpose To understand the currently available post-marketing real-world evidence of the incidences of and discontinuations due to the BAEs of irritability, anger, and aggression in people with epilepsy (PWE) treated with the anti-seizure medications

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9d334e8da5586923e8e2d6e0440a4ec
https://pubmed.ncbi.nlm.nih.gov/33839453

Time course of drug-related treatment-emergent adverse side effects of brivaracetam

Autor: Cédric Laloyaux, Pavel Klein, Jesse Fishman, Kimford J. Meador, Sami Elmoufti, Teresa Gasalla, Melinda S. Martin

Publikováno v: Epilepsybehavior : EB. 111

Treatment-emergent adverse events (TEAEs) in clinical trials are typically reported for the full duration of the treatment period including titration and maintenance. Drug-related central nervous system (CNS) TEAEs are common with antiseizure medicat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0686a05d60b0499d01ebcb1c446447f2
https://pubmed.ncbi.nlm.nih.gov/32544700

Long-term efficacy and tolerability of adjunctive brivaracetam in adults with focal to bilateral tonic-clonic (secondary generalized) seizures: Post hoc pooled analysis

Autor: Svetlana Dimova, Cédric Laloyaux, Aliakbar Asadi-Pooya, Brian D. Moseley, Sami Elmoufti

Publikováno v: Epilepsy Research. 176:106694

This post hoc analysis was conducted to evaluate the efficacy, tolerability, and health-related quality of life during long-term adjunctive brivaracetam (BRV) treatment in adult patients with focal to bilateral tonic-clonic seizures (FBTCS). Patients

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ff82a9424aaf9a64e14a98ccec3d544
https://doi.org/10.1016/j.eplepsyres.2021.106694