Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Cédric, Gobet"'
Autor:
Tomaz Martini, Cédric Gobet, Andrea Salati, Jérôme Blanc, Aart Mookhoek, Michael Reinehr, Graham Knott, Jessica Sordet-Dessimoz, Felix Naef
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Recent single-cell transcriptomes revealed spatiotemporal programmes of liver function on the sublobular scale. However, how sexual dimorphism affected this space-time logic remained poorly understood. We addressed this by performing scRNA-s
Externí odkaz:
https://doaj.org/article/9e9bdb71bacb4ff8af482b2abcca9b53
Publikováno v:
PLoS Genetics, Vol 18, Iss 8, p e1009903 (2022)
In eukaryotes, RNA is synthesised in the nucleus, spliced, and exported to the cytoplasm where it is translated and finally degraded. Any of these steps could be subject to temporal regulation during the circadian cycle, resulting in daily fluctuatio
Externí odkaz:
https://doaj.org/article/df26698a2f2b489d85c09f5065e6675a
Publikováno v:
Open Biology, Vol 10, Iss 12 (2020)
Protein synthesis from mRNA is an energy-intensive and tightly controlled cellular process. Translation elongation is a well-coordinated, multifactorial step in translation that undergoes dynamic regulation owing to cellular state and environmental d
Externí odkaz:
https://doaj.org/article/44b75c4d064343779da16cba885344b0
Autor:
Meltem Weger, Benjamin D Weger, Andrea Schink, Masanari Takamiya, Johannes Stegmaier, Cédric Gobet, Alice Parisi, Andrei Yu Kobitski, Jonas Mertes, Nils Krone, Uwe Strähle, Gerd Ulrich Nienhaus, Ralf Mikut, Frédéric Gachon, Philipp Gut, Thomas Dickmeis
Publikováno v:
eLife, Vol 9 (2020)
The glucose-sensing Mondo pathway regulates expression of metabolic genes in mammals. Here, we characterized its function in the zebrafish and revealed an unexpected role of this pathway in vertebrate embryonic development. We showed that knockdown o
Externí odkaz:
https://doaj.org/article/3ce0c8c614c1482a8e39f6ec82430ce8
Autor:
Felix Naef, Cédric Gobet
Publikováno v:
Methods. 203:10-16
Protein synthesis is an energy consuming process characterised as a pivotal and highly regulated step in gene expression. The net protein output is dictated by a combination of translation initiation, elongation and termination rates that have remain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38548ac79bb75f0f37e29aa5dbe01f96
https://doi.org/10.1016/j.ymeth.2021.10.004
https://doi.org/10.1016/j.ymeth.2021.10.004
Autor:
Anne-Sophie Delbès, Mar Quiñones, Cédric Gobet, Julien Castel, Raphaël G. P. Denis, Jérémy Berthelet, Benjamin D. Weger, Etienne Challet, Aline Charpagne, Sylviane Metairon, Julie Piccand, Marine Kraus, Bettina H. Rohde, John Bial, Elizabeth M. Wilson, Lise-Lotte Vedin, Mirko E. Minniti, Matteo Pedrelli, Paolo Parini, Frédéric Gachon, Serge Luquet
Publikováno v:
Science Advances. 9
The synchronization of circadian clock depends on a central pacemaker located in the suprachiasmatic nuclei. However, the potential feedback of peripheral signals on the central clock remains poorly characterized. To explore whether peripheral organ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2bf1dcd78f5188428a1440fc1c677196
https://doi.org/10.1126/sciadv.adf2982
https://doi.org/10.1126/sciadv.adf2982
Autor:
Laurent Perrin, Ursula Loizides-Mangold, Stéphanie Chanon, Cédric Gobet, Nicolas Hulo, Laura Isenegger, Benjamin D Weger, Eugenia Migliavacca, Aline Charpagne, James A Betts, Jean-Philippe Walhin, Iain Templeman, Keith Stokes, Dylan Thompson, Kostas Tsintzas, Maud Robert, Cedric Howald, Howard Riezman, Jerome N Feige, Leonidas G Karagounis, Jonathan D Johnston, Emmanouil T Dermitzakis, Frédéric Gachon, Etienne Lefai, Charna Dibner
Publikováno v:
eLife, Vol 7 (2018)
Circadian regulation of transcriptional processes has a broad impact on cell metabolism. Here, we compared the diurnal transcriptome of human skeletal muscle conducted on serial muscle biopsies in vivo with profiles of human skeletal myotubes synchro
Externí odkaz:
https://doaj.org/article/8ea7e67b24d542c897c0de2adf446cbc
Autor:
Anne-Sophie Delbès, Mar Quiñones, Cédric Gobet, Julien Castel, Raphaël G. P Denis, Jérémy Berthelet, Benjamin D. Weger, Etienne Challet, Aline Charpagne, Sylviane Metairon, Julie Piccand, Marine Kraus, Bettina H. Rohde, John Bial, Elizabeth M. Wilson, Lise-Lotte Vedin, Mirko E. Minniti, Matteo Pedrelli, Paolo Parini, Frédéric Gachon, Serge Luquet
The circadian clock is an evolutionarily acquired gene network that synchronizes physiological processes to adapt homeostasis to the succession of day and night. While most mammalian cells have a circadian clock, their synchronization at the body-lev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee16c364171cea92c7945d3af4cd90d8
https://doi.org/10.1101/2022.09.08.506890
https://doi.org/10.1101/2022.09.08.506890
The circadian clock modulates most of human physiology. However, the organization of tissue-specific gene expression rhythms is still poorly known, as well as age and sex dependencies. We leveraged the Genotype-Tissue Expression project (GTEx) using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ed0df12f7894192c21ccfdb84c2f3b9
https://doi.org/10.1101/2022.06.13.494714
https://doi.org/10.1101/2022.06.13.494714
Autor:
Benjamin D Weger, Meltem Weger, Benjamin Görling, Andrea Schink, Cédric Gobet, Céline Keime, Gernot Poschet, Bernard Jost, Nils Krone, Rüdiger Hell, Frédéric Gachon, Burkhard Luy, Thomas Dickmeis
Publikováno v:
PLoS Genetics, Vol 12, Iss 12, p e1006512 (2016)
Altered daily patterns of hormone action are suspected to contribute to metabolic disease. It is poorly understood how the adrenal glucocorticoid hormones contribute to the coordination of daily global patterns of transcription and metabolism. Here,
Externí odkaz:
https://doaj.org/article/4127aac261a64d66b951faaa3ff617f3