Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Cécilia Hognon"'
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2517 (2023)
After a sudden and first spread of the pandemic caused by the novel SARS-CoV-2 (Severe Acute Respiratory Syndrome—Coronavirus 2) wild-type strain, mutants have emerged which have been associated with increased infectivity, inducing surges in the co
Externí odkaz:
https://doaj.org/article/78205ae866374313bf83f146689de478
Autor:
Tom Miclot, Cécilia Hognon, Emmanuelle Bignon, Alessio Terenzi, Stéphanie Grandemange, Giampaolo Barone, Antonio Monari
Publikováno v:
Molecules, Vol 27, Iss 10, p 3256 (2022)
DNA integrity is an important factor that assures genome stability and, more generally, the viability of cells and organisms. In the presence of DNA damage, the normal cell cycle is perturbed when cells activate their repair processes. Although effic
Externí odkaz:
https://doaj.org/article/9089be65808b4d6a930b4ad5a4b1b7c5
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 10, p 5855 (2022)
Inhibition of the papain-like protease (PLpro) of SARS-CoV-2 has been demonstrated to be a successful target to prevent the spreading of the coronavirus in the infected body. In this regard, covalent inhibitors, such as the recently proposed VIR251 l
Externí odkaz:
https://doaj.org/article/4170c0797d894b469c11f46624ca0229
Autor:
Cécilia Hognon, Emmanuelle Bignon, Guillaume Harle, Nadège Touche, Stéphanie Grandemange, Antonio Monari
Publikováno v:
Biomolecules, Vol 11, Iss 9, p 1329 (2021)
Maintaining iron homeostasis is fundamental for almost all living beings, and its deregulation correlates with severe and debilitating pathologies. The process is made more complicated by the omnipresence of iron and by its role as a fundamental comp
Externí odkaz:
https://doaj.org/article/07f94792d1804e92a9a1487253e1647a
Autor:
Cécilia Hognon, Antonio Monari
Publikováno v:
Molecules, Vol 26, Iss 13, p 3986 (2021)
Artemis is an endonuclease responsible for breaking hairpin DNA strands during immune system adaptation and maturation as well as the processing of potentially toxic DNA lesions. Thus, Artemis may be an important target in the development of anticanc
Externí odkaz:
https://doaj.org/article/188421e4f23d4e94a4905d0dabe95f72
Publikováno v:
International Journal of Molecular Sciences
Volume 24
Issue 3
Pages: 2517
Volume 24
Issue 3
Pages: 2517
After a sudden and first spread of the pandemic caused by the novel SARS-CoV-2 (Severe Acute Respiratory Syndrome—Coronavirus 2) wild-type strain, mutants have emerged which have been associated with increased infectivity, inducing surges in the co
Autor:
Janske Nel, David Siniscalco, Cécilia Hognon, Mathilde Bouché, Nadége Touche, Émilie Brunner, Philippe C. Gros, Antonio Monari, Stéphanie Grandemange, Grégory Francius
Publikováno v:
Nanoscale. 14:2735-2749
Iron(ii)-based complexes were able to penetrate into the cytoplasm without disrupting the cell membrane. The complexes induced size, morphological, stiffness and cytoarchitectural changes in both triple negative breast cancer and normal cells.
Autor:
Alessio Terenzi, Emmanuelle Bignon, Giampaolo Barone, Antonio Monari, Tom Miclot, Cécilia Hognon, Marco Marazzi
Publikováno v:
The Journal of Physical Chemistry Letters
Guanine quadruplex (G4) structures in the viral genome have a key role in modulating viruses' biological activity. While several DNA G4 structures have been experimentally resolved, RNA G4s are definitely less explored. We report the first calculated
Autor:
Giampaolo Barone, Antonio Monari, Tao Jiang, Cécilia Hognon, Elise Dumont, Emmanuelle Bignon, Jeremy Morere, Tom Miclot
Publikováno v:
Journal of Chemical Information and Modeling
Journal of Chemical Information and Modeling, 2022, 62 (12), pp.3096-3106. ⟨10.1021/acs.jcim.2c00315⟩
Journal of Chemical Information and Modeling, 2022, 62 (12), pp.3096-3106. ⟨10.1021/acs.jcim.2c00315⟩
The STimulator of INterferon Genes (STING) protein is a cornerstone of the human immune response. Its activation by cGAMP upon the presence of cytosolic DNA stimulates the production of type I interferons and inflammatory cytokines which are crucial
Publikováno v:
Dalton Transactions
Dalton Transactions, Royal Society of Chemistry, 2020, 49 (33), pp.11451-11466. ⟨10.1039/D0DT02135K⟩
Dalton Transactions, Royal Society of Chemistry, 2020, 49 (33), pp.11451-11466. ⟨10.1039/D0DT02135K⟩
International audience; In this perspective, we discuss iron-complexes as drug candidates that are promising alternatives to conventional platinum-based chemotherapies owing to their broad range of reactivities and to the targeting of different biolo