Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Cécile Thirant"'
Autor:
Alexandre Fagnan, Zakia Aid, Marie Baille, Aneta Drakul, Elie Robert, Cécile K. Lopez, Cécile Thirant, Yann Lecluse, Julie Rivière, Cathy Ignacimouttou, Silvia Salmoiraghi, Eduardo Anguita, Audrey Naimo, Christophe Marzac, Françoise Pflumio, Sébastien Malinge, Christian Wichmann, Yun Huang, Camille Lobry, Julie Chaumeil, Eric Soler, Jean‐Pierre Bourquin, Claus Nerlov, Olivier A. Bernard, Juerg Schwaller, Thomas Mercher
Publikováno v:
HemaSphere, Vol 8, Iss 6, Pp n/a-n/a (2024)
Abstract Transcriptional cofactors of the ETO family are recurrent fusion partners in acute leukemia. We characterized the ETO2 regulome by integrating transcriptomic and chromatin binding analyses in human erythroleukemia xenografts and controlled E
Externí odkaz:
https://doaj.org/article/03efbfad1704429ab5fd121446f5b220
Autor:
Cécile Thirant, Agathe Peltier, Simon Durand, Amira Kramdi, Caroline Louis-Brennetot, Cécile Pierre-Eugène, Margot Gautier, Ana Costa, Amandine Grelier, Sakina Zaïdi, Nadège Gruel, Irène Jimenez, Eve Lapouble, Gaëlle Pierron, Déborah Sitbon, Hervé J. Brisse, Arnaud Gauthier, Paul Fréneaux, Sandrine Grossetête, Laura G. Baudrin, Virginie Raynal, Sylvain Baulande, Angela Bellini, Jaydutt Bhalshankar, Angel M. Carcaboso, Birgit Geoerger, Hermann Rohrer, Didier Surdez, Valentina Boeva, Gudrun Schleiermacher, Olivier Delattre, Isabelle Janoueix-Lerosey
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Noradrenergic and mesenchymal identities have been characterized in neuroblastoma cell lines according to their epigenetic landscapes and core regulatory circuitries. However, their relationship and relative contribution in patient tumors re
Externí odkaz:
https://doaj.org/article/04ed19984e944c97b2d0494d3dadfd31
Autor:
Birgit Geoerger, Aurélien Marabelle, Gaelle Pierron, Nadege Gruel, Arnaud Gauthier, Olivier Delattre, Gudrun Schleiermacher, Ana Costa, Cécile Thirant, Amira Kramdi, Cécile Pierre-Eugène, Caroline Louis-Brennetot, Orphée Blanchard, Didier Surdez, Eve Lapouble, Deborah Sitbon, Hervé Brisse, Paul Fréneaux, Mylène Bohec, Virginie Raynal, Sylvain Baulande, Renaud Leclere, Gabriel Champenois, Andre Nicolas, Didier Meseure, Angela Bellini, Fatima Mechta-Grigoriou, Laurie Menger, Isabelle Janoueix-Lerosey
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 8 (2022)
Background High-risk neuroblastoma is a pediatric cancer with still a dismal prognosis, despite multimodal and intensive therapies. Tumor microenvironment represents a key component of the tumor ecosystem the complexity of which has to be accurately
Externí odkaz:
https://doaj.org/article/94bfccd475c140a08e383b0eb1c1e8c1
Autor:
Katharina Leonards, Marwa Almosailleakh, Samantha Tauchmann, Frederik Otzen Bagger, Cécile Thirant, Sabine Juge, Thomas Bock, Hélène Méreau, Matheus F. Bezerra, Alexandar Tzankov, Robert Ivanek, Régine Losson, Antoine H. F. M. Peters, Thomas Mercher, Juerg Schwaller
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Loss of function mutations of NSD1 occur in blood cancers. Here, the authors report that NSD1 loss blocks erythroid differentiation which leads to an erythroleukemia-like disease in mice by impairing GATA1-induced target gene activation.
Externí odkaz:
https://doaj.org/article/23f6a9ca034c46419734966b67ed3c71
Autor:
Salvatore Nicola Bertuccio, Fabien Boudia, Marie Cambot, Cécile K. Lopez, Larissa Lordier, Alessandro Donada, Elie Robert, Cécile Thirant, Zakia Aid, Salvatore Serravalle, Annalisa Astolfi, Valentina Indio, Franco Locatelli, Andrea Pession, William Vainchenker, Riccardo Masetti, Hana Raslova, Thomas Mercher
Publikováno v:
HemaSphere, Vol 4, Iss 1, p e319 (2020)
Externí odkaz:
https://doaj.org/article/459233ad5d934df4aa73941de5a2441f
Publikováno v:
Cancers, Vol 13, Iss 12, p 2904 (2021)
Neuroblastoma, a pediatric cancer of the peripheral sympathetic nervous system, is characterized by an important clinical heterogeneity, and high-risk tumors are associated with a poor overall survival. Neuroblastoma cells may present with diverse mo
Externí odkaz:
https://doaj.org/article/403bc3a535154c58bbe3c1149eaa417c
Publikováno v:
Molecular & Cellular Oncology, Vol 4, Iss 6 (2017)
The ETO2-GLIS2 fusion oncoprotein is associated with poor prognosis pediatric acute megakaryoblastic leukemia. Recently, we observed that ETO2-GLIS2 controls enhancers activity at genes regulating haematopoietic progenitor self-renewal and differenti
Externí odkaz:
https://doaj.org/article/bf374fec8390479c838deeee62c2d1d0
Autor:
Cécile Thirant, Barbara Bessette, Pascale Varlet, Stéphanie Puget, Josette Cadusseau, Silvina Dos Reis Tavares, Jeanne-Marie Studler, David Carlos Silvestre, Aurélie Susini, Chiara Villa, Catherine Miquel, Alexandra Bogeas, Anne-Laure Surena, Amélia Dias-Morais, Nadine Léonard, Françoise Pflumio, Ivan Bièche, François D Boussin, Christian Sainte-Rose, Jacques Grill, Catherine Daumas-Duport, Hervé Chneiweiss, Marie-Pierre Junier
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e16375 (2011)
BackgroundPrimitive brain tumors are the leading cause of cancer-related death in children. Tumor cells with stem-like properties (TSCs), thought to account for tumorigenesis and therapeutic resistance, have been isolated from high-grade gliomas in a
Externí odkaz:
https://doaj.org/article/f701510a0d5548259cc87a1a8a01b440
Autor:
Thomas Mercher, Juerg Schwaller, Françoise Pflumio, Arnaud Petit, Berthold Göttgens, Olivier A. Bernard, Isabelle Godin, Camille Lobry, Nathalie Droin, Claus Nerlov, Sébastien Malinge, Franco Locatelli, Riccardo Masetti, Muriel Gaudry, William Vainchenker, Antoine H.F.M. Peters, Eric Delabesse, Jean Luc Villeval, Loélia Babin, Erika Brunet, Yann Lecluse, Bastien Job, M'Boyba Diop, Sarah J. Kinston, Marie-Laure Arcangeli, Alexandre Fagnan, Cécile Thirant, Fabien Boudia, Hélène Lapillonne, Chrystèle Bilhou-Nabera, Paola Ballerini, Zakia Aid, Elie Robert, Vaia Stavropoulou, Esteve Noguera, Cécile K. Lopez
Supplementary Figures and Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c6233b36f8abf7eae64d98bfa44da91
https://doi.org/10.1158/2159-8290.22536997.v1
https://doi.org/10.1158/2159-8290.22536997.v1
Autor:
Thomas Mercher, Juerg Schwaller, Françoise Pflumio, Arnaud Petit, Berthold Göttgens, Olivier A. Bernard, Isabelle Godin, Camille Lobry, Nathalie Droin, Claus Nerlov, Sébastien Malinge, Franco Locatelli, Riccardo Masetti, Muriel Gaudry, William Vainchenker, Antoine H.F.M. Peters, Eric Delabesse, Jean Luc Villeval, Loélia Babin, Erika Brunet, Yann Lecluse, Bastien Job, M'Boyba Diop, Sarah J. Kinston, Marie-Laure Arcangeli, Alexandre Fagnan, Cécile Thirant, Fabien Boudia, Hélène Lapillonne, Chrystèle Bilhou-Nabera, Paola Ballerini, Zakia Aid, Elie Robert, Vaia Stavropoulou, Esteve Noguera, Cécile K. Lopez
Fusion oncogenes are prevalent in several pediatric cancers, yet little is known about the specific associations between age and phenotype. We observed that fusion oncogenes, such as ETO2–GLIS2, are associated with acute megakaryoblastic or other m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2fd66953216bdf65b5759d7bb2637d92
https://doi.org/10.1158/2159-8290.c.6548296.v1
https://doi.org/10.1158/2159-8290.c.6548296.v1