Inferring geometrical dynamics of cell nucleus translocation

Autor: Sirine Amiri, Yirui Zhang, Andonis Gerardos, Cécile Sykes, Pierre Ronceray

Publikováno v: Physical Review Research, Vol 6, Iss 4, p 043030 (2024)

The ability of eukaryotic cells to squeeze through constrictions is limited by the stiffness of their large and rigid nucleus. However, migrating cells are often able to overcome this limitation and pass through constrictions much smaller than their

Externí odkaz: https://doaj.org/article/1937f801a8744b7b90950783238ecbc1

Reconstitution of Actin-Based Motility with Commercially Available Proteins

Autor: Julie Plastino, Cécile Sykes

Publikováno v: Journal of visualized experiments : JoVE. (188)

Many cell movements and shape changes and certain types of intracellular bacterial and organelle motility are driven by the biopolymer actin that forms a dynamic network at the surface of the cell, organelle, or bacterium. The biochemical and mechani

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3b713279d6ddca40d4a8322588e9fb3
https://pubmed.ncbi.nlm.nih.gov/36373911

Nesprins are mechanotransducers that discriminate epithelial–mesenchymal transition programs

Autor: Edgar R. Gomes, Pietro Salvatore Carollo, Cécile Sykes, Bruno Cadot, Théophile Déjardin, François Sipieter, Cynthia Seiler, Damien Cuvelier, Patricia M. Davidson, Nicolas Borghi

Publikováno v: Journal of Cell Biology
Journal of Cell Biology, Rockefeller University Press, 2020, 219, ⟨10.1083/jcb.201908036⟩
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
The Journal of Cell Biology

© 2020 Déjardin et al. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61c2c79db6f3153c68519de48c007b4f
https://doi.org/10.1083/jcb.201908036

Actin modulates shape and mechanics of tubular membranes

Autor: John Manzi, Martin Lenz, Françoise Brochard-Wyart, Karine Guevorkian, Antoine Allard, Camille Simon, Joël Lemière, Timo Betz, Clément Campillo, Julie Plastino, Cécile Sykes, Mehdi Bouzid, Majdouline Abou-Ghali, Fabrice Valentino

Publikováno v: Science Advances
Science Advances, American Association for the Advancement of Science (AAAS), 2020, 6 (17), pp.eaaz3050. ⟨10.1126/sciadv.aaz3050⟩
Allard, A, Bouzid, M, Betz, T, Simon, C, Abou-Ghali, M, Lemiere, J, Valentino, F, Manzi, J, Brochard-Wyart, F, Guevorkian, K, Plastino, J, Lenz, M, Campillo, C & Sykes, C 2020, ' Actin modulates shape and mechanics of tubular membranes ', Science Advances, vol. 6, no. 17, eaaz3050 . https://doi.org/10.1126/sciadv.aaz3050
bioRxiv
Science Advances, 2020, 6 (17), pp.eaaz3050. ⟨10.1126/sciadv.aaz3050⟩

The stability of membrane tubes is fine-tuned by a hundred-nanometer-thick branched actin network.
The actin cytoskeleton shapes cells and also organizes internal membranous compartments. In particular, it interacts with membranes for intracellu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5802a8203935e0f24a040392495dede1
https://hal.archives-ouvertes.fr/hal-03036944/document

Actin accumulates nesprin-2 at the front of the nucleus during confined cell migration

Autor: Bruno Cadot, Julie Plastino, Théophile Déjardin, Timo Betz, Nicolas Borghi, Cécile Sykes, Patricia M. Davidson, Aude Battistella

The mechanisms by which cells exert forces on their nuclei to migrate through openings smaller than the nuclear diameter remain unclear. In microfluidic devices, the hourglass shape of the nucleus and its strain patterns as it translocates through na

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0946ebaabbbba8096c52048a84c60fff
https://hal.archives-ouvertes.fr/hal-02325848