Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Cécile Servais"'
Publikováno v:
Pharmaceutics, Vol 14, Iss 5, p 952 (2022)
The anticancer agent abiraterone suffers from an extensive positive food effect after oral intake of the prodrug abiraterone acetate (Zytiga). The underlying processes determining postprandial abiraterone absorption were investigated in this study. T
Externí odkaz:
https://doaj.org/article/5ebac72322a24ee6b411e78f3dbfc1f4
Autor:
Marlies Braeckmans, Joachim Brouwers, Danny Riethorst, Cécile Servais, Jan Tack, Patrick Augustijns
Publikováno v:
Pharmaceutics, Vol 14, Iss 1, p 119 (2022)
The bioavailability of lipophilic drugs may or may not be increased when administered with food due to increased solubilisation in fed state gastrointestinal (GI) fluids. The in vivo interplay between drug solubilisation, lipid phase digestion and dr
Externí odkaz:
https://doaj.org/article/b6838333fb984d3bad448e65af00e919
Publikováno v:
International journal of pharmaceutics. 621
The lipolysis-mediated postprandial small intestinal environment is known to influence the solubilisation and subsequent absorption of lipophilic drugs. In a previously performed small-scale clinical study in healthy volunteers, co-administration of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::686781089a3e751c97fab65f03aad6d5
https://pubmed.ncbi.nlm.nih.gov/35533920
https://pubmed.ncbi.nlm.nih.gov/35533920
Autor:
Joachim Brouwers, Imke Masuy, Marlies Braeckmans, Jan Tack, Cécile Servais, Patrick Augustijns
Publikováno v:
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 142
In fasting conditions, the gastrointestinal system contracts according to the interdigestive migrating motor complex (MMC), in which phases of quiescence (MMC phase I) alternate with phases of medium (MMC phase II) to very strong (MMC phase III) cont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fe524308b1e721732a91b8c9e895adc
https://pubmed.ncbi.nlm.nih.gov/31682976
https://pubmed.ncbi.nlm.nih.gov/31682976
Autor:
Pierre-François Chavez, Lauranne Netchacovitch, Pierre-Yves Sacre, Cécile Servais, Philippe Hubert, Régis Klinkenberg, Charlotte De Bleye, Eric Ziemons, Bruno Streel
Publikováno v:
International Journal of Pharmaceutics. 484:85-94
Newly developed drugs often have poor bioavailability due to their poor water solubility (BCS class 2 drugs). It is therefore necessary to develop new strategies to enhance their solubility and their activity, among which, Self-Emulsifying Drug Deliv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3f264ea8eb453993f86c96fff18659d
https://doi.org/10.1016/j.ijpharm.2015.02.052
https://doi.org/10.1016/j.ijpharm.2015.02.052