Výsledky vyhledávání - "Cécile Ruault"

The Discovery of Tadalafil: A Novel and Highly Selective PDE5 Inhibitor. 1: 5,6,11,11a-Tetrahydro-1H-imidazo[1‘,5‘:1,6]pyrido[3,4-b]indole-1,3(2H)-dione Analogues

Autor: Alain Claude-Marie Daugan, Francois Hyafil, Jorge Kirilovsky, Hervé Coste, Anne-Charlotte de Gouville, Cécile Ruault, Richard Frederic Labaudiniere, Pascal Grondin

Publikováno v: Journal of Medicinal Chemistry. 46:4525-4532

Starting from ethyl beta-carboline-3-carboxylate (beta-CCE), 1, a modest inhibitor of type 5 phosphodiesterase (PDE5), a series of functionalized tetrahydro-beta-carboline derivatives has been identified as a novel chemical class of potent and select

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fefc764d9520b29015f394c2c2648146
https://doi.org/10.1021/jm030056e

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The discovery of tadalafil: a novel and highly selective PDE5 inhibitor. 2: 2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione analogues

Autor: Anne-Charlotte de Gouville, Pascal Grondin, Cécile Ruault, Jean Michel Linget, Francois Hyafil, Richard Frederic Labaudiniere, Alain Claude-Marie Daugan, Jorge Kirilovsky, Hervé Coste

Publikováno v: Journal of medicinal chemistry. 46(21)

Modification of the hydantoin ring in the previously described lead compound 2a has led to the discovery of compound 12a, tadalafil, a highly potent and highly selective PDE5 inhibitor. The replacement of the hydantoin in compound 2a by a piperazined

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa7f3a8a7236df75151a560bbf5d9d73
https://pubmed.ncbi.nlm.nih.gov/14521415

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