Zobrazeno 1 - 10
of 167
pro vyhledávání: '"Cécile Rochette-Egly"'
Autor:
Yassmine Chebaro, Serena Sirigu, Ismail Amal, Régis Lutzing, Roland H Stote, Cécile Rochette-Egly, Natacha Rochel, Annick Dejaegere
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0171043 (2017)
Retinoic acid (RA) plays key roles in cell differentiation and growth arrest through nuclear retinoic acid receptors (RARs), which are ligand-dependent transcription factors. While the main trigger of RAR activation is the binding of RA, phosphorylat
Externí odkaz:
https://doaj.org/article/b60cf716b04d4b34a088cf4de395e4a3
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 7, Pp 1761-1775 (2013)
Vitamin A or retinol is arguably the most multifunctional vitamin in the human body, as it is essential from embryogenesis to adulthood. The pleiotropic effects of vitamin A are exerted mainly by one active metabolite, all-trans retinoic acid (atRA),
Externí odkaz:
https://doaj.org/article/eef523f23d474f1db187db9aa2286692
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0157290 (2016)
Retinoic acid (RA), the main active vitamin A metabolite, controls multiple biological processes such as cell proliferation and differentiation through genomic programs and kinase cascades activation. Due to these properties, RA has proven anti-cance
Externí odkaz:
https://doaj.org/article/c3a802d9e183447da47398dea8df3331
Autor:
Andrea Acquavita, Laura Brunelli, Adriana Zanetti, Roberta Pastorelli, Maurizio Gianni, Gabriela Paroni, Mineko Terao, Mami Kurosaki, Cécile Rochette-Egly, Enrico Garattini, Maddalena Fratelli, Marco Bolis, Monica Lupi
Publikováno v:
Oncogene
Oncogene, 2019, 38 (14), pp.2482-2500. ⟨10.1038/s41388-018-0599-z⟩
Oncogene, 2019, 38 (14), pp.2482-2500. ⟨10.1038/s41388-018-0599-z⟩
All trans-retinoic acid (ATRA) is used in the treatment of acute promyelocytic leukemia (APL) and it is a promising agent also in solid tumors. The pharmacological activity of ATRA is mediated by the ligand-activated RAR and RXR transcription factors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15deea47a06030174cbec57d149e8572
http://europepmc.org/articles/PMC6484772
http://europepmc.org/articles/PMC6484772
Autor:
Yassmine Chebaro, Ismail Amal, Natacha Rochel, Cécile Rochette-Egly, Roland H Stote, Annick Dejaegere
Publikováno v:
PLoS Computational Biology, Vol 9, Iss 4, p e1003012 (2013)
Nuclear receptor proteins constitute a superfamily of proteins that function as ligand dependent transcription factors. They are implicated in the transcriptional cascades underlying many physiological phenomena, such as embryogenesis, cell growth an
Externí odkaz:
https://doaj.org/article/47e46ec66d354c34b6bb4118eeab95d1
Autor:
Cécile Rochette-Egly
Publikováno v:
Subcellular Biochemistry ISBN: 9783030422806
Retinoic acid (RA), a major natural active metabolite of vitamin A (VA) is well known to play critical roles in embryonic development. The effects of RA are mediated by nuclear receptors (RARs), which regulate the expression of gene batteries involve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99762081f38191b9880b8b78b8adab9b
https://doi.org/10.1007/978-3-030-42282-0_3
https://doi.org/10.1007/978-3-030-42282-0_3
Publikováno v:
FEBS Letters
FEBS Letters, 2018, 592 (8), pp.1426-1433. ⟨10.1002/1873-3468.13033⟩
FEBS Letters, 2018, 592 (8), pp.1426-1433. ⟨10.1002/1873-3468.13033⟩
The nuclear retinoic acid (RA) receptors (RARalpha, beta and gamma) are ligand-dependent regulators of transcription. Upon activation by RA, they are recruited at the promoters of target genes together with several coregulators. Then, they are degrad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b80bfa4e89c85f6f2ef09e2598f9e0b4
https://doi.org/10.1002/1873-3468.13033
https://doi.org/10.1002/1873-3468.13033
Publikováno v:
Biochemical and Biophysical Research Communications. 495:846-853
Retinoic acid receptors (RARs) are classically considered as nuclear ligand-dependent regulators of transcription. Here we highlighted a novel face of the RARα subtype: RARα is present in low amounts in the cytoplasm of mouse embryonic fibroblasts
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8088122540904eaaa5835c384cbfc804
https://doi.org/10.1016/j.bbrc.2017.11.096
https://doi.org/10.1016/j.bbrc.2017.11.096
This book covers subjects that have major impacts on society, such as the mechanism of maternal-fetal transfer of vitamin A, and the effects of alcohol on retinoic acid signaling and mammalian embryonic development. There has been an awareness of the
Autor:
Gianmaria Borleri, Gabriela Paroni, Alessandro Rambaldi, Maurizio Gianni, Mami Kurosaki, Adriana Zanetti, Maddalena Fratelli, Marco Bolis, Enrico Garattini, Cécile Rochette-Egly, Mineko Terao
Publikováno v:
Oncotarget
Oncotarget, 2017, 8 (23), pp.37041-37060. ⟨10.18632/oncotarget.10556⟩
Oncotarget, 2017, 8 (23), pp.37041-37060. ⟨10.18632/oncotarget.10556⟩
Treatment of acute promyelocytic leukemia (APL) with all-trans retinoic acid (ATRA) is the first example of targeted therapy. In fact, the oncogenic fusion-protein (PML-RAR) typical of this leukemia contains the retinoid-nuclear-receptor RARalpha. PM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5cf032a2015656f04b988454cce1b17
https://doi.org/10.18632/oncotarget.10556
https://doi.org/10.18632/oncotarget.10556