Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Cécile L. Bandet"'
1
Akademický článek
CerS6-dependent ceramide synthesis in hypothalamic neurons promotes ER/mitochondrial stress and impairs glucose homeostasis in obese mice
Autor: Philipp Hammerschmidt, Sophie M. Steculorum, Cécile L. Bandet, Almudena Del Río-Martín, Lukas Steuernagel, Vivien Kohlhaas, Marvin Feldmann, Luis Varela, Adam Majcher, Marta Quatorze Correia, Rhena F. U. Klar, Corinna A. Bauder, Ecem Kaya, Marta Porniece, Nasim Biglari, Anna Sieben, Tamas L. Horvath, Thorsten Hornemann, Susanne Brodesser, Jens C. Brüning
Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
Abstract Dysregulation of hypothalamic ceramides has been associated with disrupted neuronal pathways in control of energy and glucose homeostasis. However, the specific ceramide species promoting neuronal lipotoxicity in obesity have remained obscur
Externí odkaz: https://doaj.org/article/0ef32131373a4665897de31f813f7c3c
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2
Akademický článek
Inhibition of central de novo ceramide synthesis restores insulin signaling in hypothalamus and enhances β-cell function of obese Zucker rats
Autor: Mélanie Campana, Lara Bellini, Claude Rouch, Latif Rachdi, Nicolas Coant, Noémie Butin, Cécile L. Bandet, Erwann Philippe, Kelly Meneyrol, Nadim Kassis, Julien Dairou, Eric Hajduch, Benoit Colsch, Christophe Magnan, Hervé Le Stunff
Publikováno v: Molecular Metabolism, Vol 8, Iss , Pp 23-36 (2018)
Objectives: Hypothalamic lipotoxicity has been shown to induce central insulin resistance and dysregulation of glucose homeostasis; nevertheless, elucidation of the regulatory mechanisms remains incomplete. Here, we aimed to determine the role of de
Externí odkaz: https://doaj.org/article/36162c8527874fe1a2f4d78629f38b0c
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3
Akademický článek
Sphingosine-1-Phosphate Metabolism in the Regulation of Obesity/Type 2 Diabetes
Autor: Jeanne Guitton, Cécile L. Bandet, Mohamed L. Mariko, Sophie Tan-Chen, Olivier Bourron, Yacir Benomar, Eric Hajduch, Hervé Le Stunff
Publikováno v: Cells, Vol 9, Iss 7, p 1682 (2020)
Obesity is a pathophysiological condition where excess free fatty acids (FFA) target and promote the dysfunctioning of insulin sensitive tissues and of pancreatic β cells. This leads to the dysregulation of glucose homeostasis, which culminates in t
Externí odkaz: https://doaj.org/article/2ab8398c59284279b40f87c07b2f11ce
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6
Sphingosine-1-Phosphate Metabolism in the Regulation of Obesity/Type 2 Diabetes
Autor: Mohamed Lamine Mariko, Hervé Le Stunff, Yacir Benomar, Cécile L. Bandet, Jeanne Guitton, Sophie Tan-Chen, Eric Hajduch, Olivier Bourron
Publikováno v: Cells
Cells, MDPI, 2020, 9 (7), pp.1682. ⟨10.3390/cells9071682⟩
Cells, Vol 9, Iss 1682, p 1682 (2020)
Obesity is a pathophysiological condition where excess free fatty acids (FFA) target and promote the dysfunctioning of insulin sensitive tissues and of pancreatic β cells. This leads to the dysregulation of glucose homeostasis, which culminates in t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea85bd510ae1eba6e9d61e6e41c27152
https://hal.archives-ouvertes.fr/hal-02902856
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7
Sphingolipid Metabolism: New Insight into Ceramide-Induced Lipotoxicity in Muscle Cells
Autor: Cécile L. Bandet, Sophie Tan-Chen, Olivier Bourron, Hervé Le Stunff, Eric Hajduch
Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, MDPI, 2019, Ceramide, 20 (3), pp.479. ⟨10.3390/ijms20030479⟩
International Journal of Molecular Sciences, MDPI, 2019, 20 (3), pp.479. ⟨10.3390/ijms20030479⟩
International Journal of Molecular Sciences, Vol 20, Iss 3, p 479 (2019)
International audience; Insulin-resistance is a characteristic feature of type 2 diabetes (T2D) and plays a major role in the pathogenesis of this disease. Skeletal muscles are quantitatively the biggest glucose users in response to insulin and are c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::e4d2e975dde401b7f64eaab4be0f13fa
https://hal.sorbonne-universite.fr/hal-02094670
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8
Ceramide Transporter CERT Is Involved in Muscle Insulin Signaling Defects Under Lipotoxic Conditions
Autor: Erwann Philippe, Athanassia Sotiropoulos, Hervé Le Stunff, Agnieszka Blachnio-Zabielska, Julien Véret, Paola Giussani, Fabienne Foufelle, Cécile L Bandet, Maxime Poirier, Xavier Le Liepvre, Olivier Bourron, Pascal Ferré, Eric Hajduch, Raphaëlle Ballaire, Jan Górski, Dušan Berkeš, Rana Mahfouz, Mélanie Campana
Publikováno v: Diabetes
Diabetes, American Diabetes Association, 2018, 67 (7), pp.1258-1271. ⟨10.2337/db17-0901⟩
Diabetes, 2018, 67 (7), pp.1258-1271. ⟨10.2337/db17-0901⟩
International audience; One main mechanism of insulin resistance (IR), a key feature of type 2 diabetes, is the accumulation of saturated fatty acids (FAs) in the muscles of obese patients with type 2 diabetes. Understanding the mechanism that underl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c98612fe781a2776f3e46af4629e39a
https://hal.archives-ouvertes.fr/hal-02450782
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