Scrt1, a transcriptional regulator of β-cell proliferation identified by differential chromatin accessibility during islet maturation

Autor: Jonathan Sobel, Claudiane Guay, Ofer Elhanani, Adriana Rodriguez-Trejo, Lisa Stoll, Véronique Menoud, Cécile Jacovetti, Michael D. Walker, Romano Regazzi

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)

Abstract Glucose-induced insulin secretion, a hallmark of mature β-cells, is achieved after birth and is preceded by a phase of intense proliferation. These events occurring in the neonatal period are decisive for establishing an appropriate functio

Externí odkaz: https://doaj.org/article/b8ebcf5f93ea4a368630185da5395111

Mechanisms Underlying the Expansion and Functional Maturation of β-Cells in Newborns: Impact of the Nutritional Environment

Autor: Cécile Jacovetti, Romano Regazzi

Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 4, p 2096 (2022)

The functional maturation of insulin-secreting β-cells is initiated before birth and is completed in early postnatal life. This process has a critical impact on the acquisition of an adequate functional β-cell mass and on the capacity to meet and a

Externí odkaz: https://doaj.org/article/cfacffcd9deb454d82d78f7933a52fdf

Small RNAs derived from tRNA fragmentation regulate the functional maturation of neonatal β cells

Autor: Mustafa Bilal, Bayazit, Cécile, Jacovetti, Cristina, Cosentino, Jonathan, Sobel, Kejing, Wu, Flora, Brozzi, Adriana, Rodriguez-Trejo, Lisa, Stoll, Claudiane, Guay, Romano, Regazzi

Publikováno v: Cell reports, vol. 40, no. 2, pp. 111069

tRNA-derived fragments (tRFs) are an emerging class of small non-coding RNAs with distinct cellular functions. Here, we studied the contribution of tRFs to the regulation of postnatal β cell maturation, a critical process that may lead to diabetes s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::e4336731b9e6e041c1712eee166e005c
https://serval.unil.ch/notice/serval:BIB_CD2CB954E2CD

Scrt1, a transcriptional regulator of β-cell proliferation identified by differential chromatin accessibility during islet maturation

Autor: Jonathan, Sobel, Claudiane, Guay, Ofer, Elhanani, Adriana, Rodriguez-Trejo, Lisa, Stoll, Véronique, Menoud, Cécile, Jacovetti, Michael D, Walker, Romano, Regazzi

Publikováno v: Scientific reports, vol. 11, no. 1, pp. 8800
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Scientific Reports

Glucose-induced insulin secretion, a hallmark of mature β-cells, is achieved after birth and is preceded by a phase of intense proliferation. These events occurring in the neonatal period are decisive for establishing an appropriate functional β-ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::8b6bbc3bb11046c31a3b45a79dc60d70
https://serval.unil.ch/notice/serval:BIB_8A32EB66F140

The Map3k12 (Dlk)/JNK3 signaling pathway is required for pancreatic beta-cell proliferation during postnatal development

Autor: Mathie Tenenbaum, Amar Abderrahmani, Amélie Bonnefond, Stéphane Dalle, Julien Bourry, Valery Gmyr, Philippe Froguel, Valérie Pawlowski, Nicole Beeler, Valérie Plaisance, Raphael Boutry, Hélène Ezanno, Clara Sanchez-Parra, Cécile Jacovetti, Romano Regazzi, Gianni Pasquetti, François Pattou, Syu-Ichi Hirai, Julie Kerr-Conte

Publikováno v: Cellular and Molecular Life Sciences
Cellular and Molecular Life Sciences, 2021, 78 (1), pp.287-298. ⟨10.1007/s00018-020-03499-7⟩
Cellular and molecular life sciences, vol. 78, no. 1, pp. 287-298
Cellular and Molecular Life Sciences, Springer Verlag, 2021, 78 (1), pp.287-298. ⟨10.1007/s00018-020-03499-7⟩

International audience; Unveiling the key pathways underlying postnatal beta-cell proliferation can be instrumental to decipher the mechanisms of beta-cell mass plasticity to increased physiological demand of insulin during weight gain and pregnancy.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebfdfb9a0f864edaf26216a8dbe28497
https://hal.science/hal-03142227/document